CP866087 - CAS 519052-02-9
Catalog number: 519052-02-9
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
C24H30N2O3S
Molecular Weight:
426.57
COA:
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Targets:
Opioid Receptor
Description:
CP866087 is a selective mu-opioid receptor antagonist.
Purity:
98%
Appearance:
Solid powder
Synonyms:
CP-866087; CP 866087; CP866087; N-[3-[(1R,5S)-6-ethyl-3-[(2-hydroxy-1,3-dihydroinden-2-yl)methyl]-3-azabicyclo[3.1.0]hexan-6-yl]phenyl]methanesulfonamide;Methanesulfonamide, N-(3-(3-((2,3-dihydro-2-hydroxy-1H-inden-2-yl)methyl)-6-ethyl-3-azabicyclo(3.1.0)hex-6-yl)phenyl)-
Solubility:
Soluble in DMSO, not in water
Storage:
-20°C Freezer
MSDS:
Inquire
Quality Standard:
In-house standard
Quantity:
Milligrams-Grams
Boiling Point:
584.4±60.0 °C | Condition: Press: 760 Torr
Density:
1.305±0.06 g/cm3 | Condition: Temp: 20 °C Press: 760 Torr
InChIKey:
ZBVPUFSKFGYNLC-RIKCKFAHSA-N
InChI:
InChI=1S/C24H30N2O3S/c1-3-24(19-9-6-10-20(11-19)25-30(2,28)29)21-14-26(15-22(21)24)16-23(27)12-17-7-4-5-8-18(17)13-23/h4-11,21-22,25,27H,3,12-16H2,1-2H3/t21-,22+,24?
Canonical SMILES:
CCC1(C2C1CN(C2)CC3(CC4=CC=CC=C4C3)O)C5=CC(=CC=C5)NS(=O)(=O)C
1.Synthesis of 3-azabicyclo[3.1.0]hexane derivatives via palladium-catalyzed cyclopropanation of maleimides with N-tosylhydrazones: practical and facile access to CP-866,087.
Chen P;Zhu C;Zhu R;Lin Z;Wu W;Jiang H Org Biomol Chem. 2017 Feb 1;15(5):1228-1235. doi: 10.1039/c6ob02137a.
A palladium-catalyzed cyclopropanation of internal alkenes with N-tosylhydrazones is presented. This gram-scale cyclopropanation reaction of maleimides provides a wide spectrum of 3-azabicyclo[3.1.0]hexane derivatives in high yields and diastereoselectivities. The major diastereoisomers could be easily isolated by chromatography on silica gel. This protocol provides a practical route to the mu opioid receptor antagonist CP-866,087.
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