CP66,948 - CAS 101189-47-3
Catalog number: 101189-47-3
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
C13H20N6S
Molecular Weight:
292.40
COA:
Inquire
Targets:
Histamine Receptor
Description:
CP66,948 is a histamine H2-receptor antagonist. It has gastric antisecretory activity and mucosal protective properties.
Purity:
>98 %
Appearance:
Solid powder
Synonyms:
2-(N-Pentyl-N'-guanidino)-4-(2-methylimidazol-4-yl)thiazole;CP-66,948 CP-66,948;1-[4-(2-methyl-1H-imidazol-5-yl)-1,3-thiazol-2-yl]-2-pentylguanidine
Solubility:
10 mM in DMSO
Storage:
-20°C Freezer
MSDS:
Inquire
Application:
CP66,948 has gastric antisecretory activity and mucosal protective properties.
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Quantity:
Milligrams-Grams
Boiling Point:
517.0±42.0 °C | Condition: Press: 760 Torr
Density:
1.34±0.1 g/cm3 | Condition: Temp: 20 °C Press: 760 Torr
InChIKey:
OZSXWXGDJLBJQO-UHFFFAOYSA-N
InChI:
InChI=1S/C13H20N6S/c1-3-4-5-6-15-12(14)19-13-18-11(8-20-13)10-7-16-9(2)17-10/h7-8H,3-6H2,1-2H3,(H,16,17)(H3,14,15,18,19)
Canonical SMILES:
CCCCCN=C(N)NC1=NC(=CS1)C2=CN=C(N2)C
1.CP-66,948: an antisecretory histamine H2-receptor antagonist with mucosal protective properties.
Hakkinen JP;Holt WF;Goddard CJ;Oates PJ;Murphy WR;Maciejko JJ;Reiter LA Dig Dis Sci. 1991 Dec;36(12):1721-8.
CP-66,948 is a histamine H2-receptor antagonist with gastric antisecretory activity and mucosal protective properties. The affinity of CP-66,948 for the guinea pig atria histamine H2-receptor is 15 times greater than that of cimetidine and seven times greater than that of ranitidine. In vivo, the ED50 value for inhibition of gastric acid secretion in pylorus-ligated rats is 2 mg/kg intraduodenally, and in histamine or pentagastrin-stimulated Heidenhain pouch dogs the antisecretory ED50 values are 0.3 mg/kg per os and 1.0 mg/kg per os, respectively. CP-66,948 also inhibits ethanol-induced gastric hemorrhagic lesions in rats following either oral or systemic administration (ED50 values of 12 mg/kg per os and 6 mg/kg subcutaneously). In addition, the mucosal protective activity is independent of prostaglandin synthesis. CP-66,948 inhibits gastric acid secretion in man, and its mucosal protective activity may provide additional benefits in peptic ulcer therapy.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Histamine Receptor Products


CAS 84545-30-2 ICI 162,846

ICI 162,846
(CAS: 84545-30-2)

ICI 162,846 is a potent histamine H2 receptor antagonist.

CAS 85604-00-8 Zaltidine

Zaltidine
(CAS: 85604-00-8)

Zaltidine is an effective but hepatotoxic H2-receptor antagonist. It has higher incidence of hepatic damage than with commonly used H2-receptor antagonists. It ...

CAS 929622-09-3 Bavisant dihydrochloride

Bavisant dihydrochloride
(CAS: 929622-09-3)

Bavisant dihydrochloride is the dihydrochloride form of Bavisant, which is a highly selective, orally active antagonist of the human H3 receptor. It may be used...

CAS 1104-22-9 Meclizine 2HCl

Meclizine 2HCl
(CAS: 1104-22-9)

Meclizine is a histamine H1 receptor antagonist used to treat nausea and motion sickness, has anti-histamine, anti-muscarinic and anti-oxidative phosphorylation...

CAS 184576-87-2 ROS 234 dioxalate

ROS 234 dioxalate
(CAS: 184576-87-2)

ROS 234 dioxalate is a potent H3 antagonist (pKB at guinea-pig ileum H3-receptor = 9.46).

CAS 869497-75-6 JNJ 10191584 maleate

JNJ 10191584 maleate
(CAS: 869497-75-6)

The maleate salt form of JNJ 10191584, which has been found to be a selective histamine H4 receptor silent antagonist and could restrain mast cell and eosinophi...

CAS 100299-08-9 Pemirolast potassium

Pemirolast potassium
(CAS: 100299-08-9)

Pemirolast potassium (BMY 26517) is a histamine H1 antagonist and mast cell stabilizer that acts as an antiallergic agent.

CAS 1229-35-2 METHDILAZINE HYDROCHLORIDE (200 MG)

METHDILAZINE HYDROCHLORIDE (200 MG)
(CAS: 1229-35-2)

This active molecular is a first-generation antihistamine and belongs to phenothiazine class. Methdilazine Hydrochloride is a Histamine H1 receptor antagonist w...

CAS 99291-25-5 Levodropropizine

Levodropropizine
(CAS: 99291-25-5)

Levodropropizine possess anti-allergic and inhibits histamine receptor, reduces cough by interfering with stimulus activation of peripheral endings of sensory n...

GS-283
(CAS: 149440-36-8)

GS-283, an isoquinolin derivative, has been found to be histamine receptor and muscarinic receptor blocker.

CAS 10500-82-0 Famotine hydrochloride

Famotine hydrochloride
(CAS: 10500-82-0)

Famotine hydrochloride is a histamine H2 receptor antagonist. lt has no effect on the cytochrome P450 enzyme system, and does not appear to interact with other ...

CAS 1394808-20-8 SUVN-G3031 hydrochloride

SUVN-G3031 hydrochloride
(CAS: 1394808-20-8)

SUVN-G3031 is a Histamine H3 receptor antagonist originated by Suven Life Sciences. Blockade of Histamine H3 receptor can augment the pre-synaptic release of bo...

CAS 68844-77-9 Astemizole

Astemizole
(CAS: 68844-77-9)

Astemizole is a potent and orally active nonsedating-type histamine H1 receptor antagonist with IC50 value of 4 nM. It competitively binds to histamine H1 recep...

CAS 14976-57-9 Clemastine Fumarate

Clemastine Fumarate
(CAS: 14976-57-9)

Clemastine Fumarate (Clemastine) is a selective histamine H1 receptor antagonist with IC50 of 3 nM.

CAS 1028327-66-3 VUF10460

VUF10460
(CAS: 1028327-66-3)

VUF10460 is a specific non-imidazole histamine H4 receptor agonist (pKi= 7.46, 8.22 for rat H4 receptor and human H4 receptor respectively) with 50-fold selecti...

CAS 1049740-32-0 A 331440 dihydrochloride

A 331440 dihydrochloride
(CAS: 1049740-32-0)

A 331440 dihydrochloride is a histamine H3 receptor antagonist (Ki = 21.7 and 22.7 nM for rat and human H3 receptors, respectively). A 331440 reduces weight in ...

CAS 639089-06-8 VUF 5681 dihydrobromide

VUF 5681 dihydrobromide
(CAS: 639089-06-8)

VUF 5681 dihydrobromide is a potent histamine H3 receptor silent antagonist (pKi = 8.35).

CAS 546-06-5 Conessine

Conessine
(CAS: 546-06-5)

Conessine is a naturally occurring steroidal dibasic alkaloid with a rigid steroid-based skeleton. It is found in a number of plant species from the apocynaceae...

CAS 58-33-3 Promethazine hydrochloride

Promethazine hydrochloride
(CAS: 58-33-3)

Promethazine hydrochloride is first-generation antihistamine of the phenothiazine family used as an antiallergic, in pruritus, for motion sickness and sedation,...

CAS 2508-72-7 Antazoline hydrochloride

Antazoline hydrochloride
(CAS: 2508-72-7)

Antazoline HCl is a first generation antihistamine, binding to the histamine H1 receptor and blocking the action of endogenous histamine.

Chemical Structure

CAS 101189-47-3 CP66,948

Quick Inquiry

Verification code

Featured Items