CP640186 HCl - CAS 591778-70-0
Catalog number: 591778-70-0
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
CP-640186 is an isozyme-nonselective acetyl-CoA carboxylase (ACC) inhibitor with IC50s of 53 nM and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2 respectively; with improved metabolic stability vs CP-610431.
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solid powder
CP640186; CP 640186
1.The effect of thermal processing on the behaviour of peanut allergen peptide targets used in multiple reaction monitoring mass spectrometry experiments.
Sayers RL1, Johnson PE1, Marsh JT1, Barran P2, Brown H3, Mills EN1. Analyst. 2016 Apr 26. [Epub ahead of print]
Mass spectrometry-based methods offer an alternative means of determining allergens in foods. Whilst targeted methods are likely to offer the most robust approach for detection and quantification, little is known about how food processing may affect the behaviour of peptide targets. A systematic study has been undertaken to investigate the effects of thermal processing (boiling, roasting, frying) on the behaviour of a suite of peanut peptide targets representing the major clinically-relevant allergens. Initially the effect of thermal processing on protein extractability was investigated and a mass spectrometry-compatible buffer identified comprising 50 mM Tris-HCl, pH 8.8 containing 50 mM dithiothreitol and 0.04% (w/v) acid labile detergent which was able to extract 45-100% of protein from raw, boiled, roasted and fried peanuts using sonication at 60 °C. Eight peptide targets were identified including two peptides from each cupin allergen, Ara h1 and Ara h3 and four peptides from the prolamin superfamily allergens Ara h2, 6 and 7.
2.Foams stabilized with solid particles carrying stimuli-responsive polymer hairs.
Nakayama S1, Hamasaki S1, Ueno K1, Mochizuki M1, Yusa S2, Nakamura Y3, Fujii S1. Soft Matter. 2016 Apr 25. [Epub ahead of print]
Submicrometer-sized polystyrene (PS) particles carrying stimuli-responsive poly[2-(diethylamino)ethyl methacrylate] (PDEA) hairs with degrees of polymerization of 30, 60 and 90 were synthesized by dispersion polymerization and used as a particulate foam stabilizer. The effects of the composition of these PDEA-PS particles and foam formation conditions on foamability, foam stability and foam microstructures were extensively investigated. The hairy particles were found to work as an effective stabilizer of aqueous foams in basic media, in which the PDEA hairs are not protonated and thus the particle surfaces exhibit suitable wettability at the air-water interface. In contrast, little to no foam or unstable foams were formed in acidic aqueous media, in which the hairs are protonated and are therefore water soluble. Particles carrying longer hairs resulted in greater foamability and more highly stabilized foams that were capable of persisting for more than one month.
3.Deproteinization of water-soluble ß-glucan during acid extraction from fruiting bodies of Pleurotus ostreatus mushrooms.
Szwengiel A1, Stachowiak B2. Carbohydr Polym. 2016 Aug 1;146:310-9. doi: 10.1016/j.carbpol.2016.03.015. Epub 2016 Mar 9.
Some ß-glucans can be easily extracted from Basidiomycete mushrooms but commonly used extraction procedures are not satisfactory. A simultaneous method for acid extraction and deproteinization in the case of Pleurotus ostreatus was developed using response surface methodology. The optimized extraction conditions proposed here (30°C, 3.8% HCl, 300min, stirring) allow for the simultaneous extraction and deproteinization of polysaccharides. Additionally, the acid extraction yield was 7 times greater than that of hot water extraction. The combined enzymatic digestion with lyticase, ß-glucanase, exo-1,3-ß-d-glucanase, and ß-glucosidase results elucidated that an extract containing ß-1,3-ß-1,6-ß-1,4-glucan. The gel permeation chromatography (GPC) results showed that the two glucan fractions obtained do not contain linked proteins. The weight average molecular weight of the first fraction (Mw=1137kDa) was 60 times higher than that of the second fraction (Mw=19kDa).
4.A FRET-based fluorescent probe for mercury ions in water and living cells.
Zhang B1, Ma P1, Gao D2, Wang X1, Sun Y1, Song D1, Li X3. Spectrochim Acta A Mol Biomol Spectrosc. 2016 Apr 19;165:99-105. doi: 10.1016/j.saa.2016.04.037. [Epub ahead of print]
On the basis of fluorescence resonance energy transfer (FRET), a new rhodamine derivative (DRh) was synthesized as a ratiometric fluorescent probe for detecting Hg2+ in water and living cells samples. The recognition properties of the probe DRh with metal ions had been investigated in H2O/CH3CN (9:1, v/v; Tris-HCl 50mmolL-1; pH=7.0) solution by the UV-Vis spectrophotometry and the fluorescence spectrophotometry. The results showed that the probe DRh exhibited the selective recognition of Hg2+. Upon the addition of Hg2+, the spirolactam ring of probe DRh was opened. The 1:1 stoichiometric structure between DRh and Hg2+ were supported by Job's plot, MS and DFT theoretical calculations. The linearly fluorescence intensity ratio (I582/I538) is proportional to the concentration of Hg2+ in the range 0-30μmolL-1. The limit of detection (LOD) of Hg2+ is 0.008μmolL-1 (base on S/N=3). The present probe was applied to the determination of Hg2+ in neutral water samples and gave recoveries ranging from 104.
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CAS 591778-70-0 CP640186 HCl

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