CP 99433 - CAS 147059-71-0
Catalog number: 147059-71-0
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
C17H17FN4O3
Molecular Weight:
344.34
COA:
Inquire
Targets:
Antibacterial
Description:
CP 99433, a fluoroquinolone derivative, has been found to be a Type II DNA topoisomerase inhibitor that could be probably effective as an antibacterial agent.
Purity:
98%
Appearance:
Powder
Synonyms:
CP 99433; CP99433; CP-99433. 3-Azabicyclo[3.1.0]hexane, 1,8-naphthyridine-3-carboxylic acid deriv; 1,​8-​Naphthyridine-​3-​carboxylic acid, 7-​(6-​amino-​3-​azabicyclo[3.1.0]​hex-​3-​yl)​-​1-​cyclopropyl-​6-​fluoro-​1,​4-​dihydro-​4-​oxo-​, (1α,​5α,​6α)​-
Storage:
Store in a cool and dry place and at 0 - 4 °C for short term (days to weeks) or -20 °C for long term (months to years).
MSDS:
Inquire
Quality Standard:
In-house standard
Quantity:
Milligram-Grams
Boiling Point:
603.6±55.0 °C at 760 Torr
Density:
1.620±0.06 g/cm3
InChIKey:
HPQJHUNCWWNOJL-HWYHXSKPSA-N
InChI:
InChI=1S/C17H17FN4O3/c18-12-3-8-14(23)11(17(24)25)6-22(7-1-2-7)15(8)20-16(12)21-4-9-10(5-21)13(9)19/h3,6-7,9-10,13H,1-2,4-5,19H2,(H,24,25)/t9-,10+,13?
Canonical SMILES:
C1CC1N2C=C(C(=O)C3=CC(=C(N=C32)N4CC5C(C4)C5N)F)C(=O)O
1.In vitro antimicrobial activity of CP-99433 compared with other fluoroquinolones.
Johnson DM;Jones RN;Erwin ME Diagn Microbiol Infect Dis. 1993 Jul;17(1):79-83.
CP-99433 is a new C-7 diazabicyclofluoroquinolone with a broad spectrum of activity that includes Enterobacteriaceae, Gram-positive cocci, and nonenteric Gram-negative bacilli. Potent activity was demonstrated against Pseudomonas aeruginosa [minimum inhibitory concentration (MIC90, 0.5 microgram/ml), Xanthomonas maltophilia (MIC90, 1 microgram/ml), and all Streptococcus species (MIC90s, 0.25-1 microgram/ml). Only CP-99433 was active against Enterococcus faecium (MIC50, 2 micrograms/ml). CP-99433 also demonstrated activity against several ciprofloxacin-resistant staphylococci. Additional studies of CP-99433 activity appear indicated.
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