GSK1997132B
(CAS: 1168138-37-1)

PPARγ is a ligand-activated nuclear receptor and was reported to plays a role in energy metabolism, glucose homeostasis and microglia-mediated neuroinflammation...

Oleuropein
(CAS: 32619-42-4)

Oleuropein is a polyphenol found in olive leaves and fruits. Oleuropein displays antioxidant, anti-ischemic and hypolipidemic activity. It has an antagonistic e...

15-deoxy-Δ12,14-Prostaglandin J2
(CAS: 87893-55-8)

15-deoxy-Δ12,14-Prostaglandin J2 is a TRPA1 agonist and an endogenous PPARγ ligand that induces adipocyte differentiation in C3H10Y1/2 fibroblasts (EC50 = 7 μM)...

GW501516
(CAS: 317318-70-0)

GW501516 is a potent and highly selective PPARβ/δ agonist, with EC50 of 1 nM, with 1000-fold selectivity over hPPARα and hPPARγ. Phase 4.

Pioglitazone HCl
(CAS: 112529-15-4)

Pioglitazone HCl is a hydrochloride salt form of pioglitazone which is a cytochrome P450 (CYP)2C8 and CYP3A4 enzymes inhibitor for CYP2C8, CYP3A4 and CYP2C9 wit...

Pirinixic Acid
(CAS: 50892-23-4)

WY 14643 (Pirinixic Acid) is a potent peroxisome proliferator and activator of PPARα with EC50 of 1.5 μM.

Oleylethanolamide
(CAS: 111-58-0)

Oleylethanolamide is an endogenous agonist for PPARα with an EC50 value of 120 nM in a transactivation assay. Oleylethanolamide is also a selective GPR55 agonis...

Troglitazone
(CAS: 97322-87-7)

Troglitazone, PPARγ agonist, is an anti-diabetic thiazolidinedione (TZD) with anti-inflammatory and anti-tumor activity, which was approved for the treatment of...

BADGE
(CAS: 1675-54-3)

BADGE is a PPARγ antagonist with selectivity over PPARδ and PPARα. It inhibits adipocyte differentiation, and induces apoptosis in cancer cells. BADGE also exhi...

GW0742
(CAS: 317318-84-6)

GW0742 is a potent and highly selective PPARβ/δ agonist, with IC50 of 1 nM, with 1000-fold selectivity over hPPARα and hPPARγ.

Clofibrate
(CAS: 637-07-0)

Clofibrate is a fibric acid derivative used in the treatment of hyperlipoproteinemia type III and severe hypertriglyceridemia.

MHY 908
(CAS: 1393371-39-5)

MHY 908 is a dual PPARα/γ agonist and a melanogenesis inhibitor that suppresses mushroom tyrosinase activity (IC50 value 8.19 μM). MHY908 exhibits more potent a...

DG172 dihydrochloride
(CAS: 1361504-77-9)

The dihydrochloride salt form of DG-172, a piperazin drrivative, is a PPARβ/δ inverse agonist that could promote cell differentiation of dendritic induced by GM...

Edaglitazone
(CAS: 213411-83-7)

Edaglitazone is a potent and selective PPARγ agonist (EC50 = 35.6 and 1053 nM for PPARγ and PPARα cofactor recruitment respectively). Edaglitazone enhances insu...

CDDO Imidazolide
(CAS: 443104-02-7)

CDDO Imidozolide is a synthetic triterpenoid as Nrf2 signaling activator with highly active in suppressing cellular proliferation of human leukemia and breast c...

SR 1664
(CAS: 1338259-05-4)

SR 1664 is a PPARγ (peroxisome proliferator-activated receptor γ ) inhibitor. SR 1664 can block PPARγ by cyclin-dependent kinase 5 with an IC50 value of 80 nM a...

GW 7647
(CAS: 265129-71-3)

GW 7647 is a potent and highly selective PPARα agonist (EC50 = 6, 1100 and 6200 nM for human PPARα, PPARγ and PPARδ receptors, respectively) with 200-fold selec...

Indeglitazar
(CAS: 835619-41-5)

Indeglitazar is a peroxisome proliferator-activated receptor (PPAR) pan-agonist. Phase II clinical trials for Type 2 diabetes mellitus was discontinued.

PPAR agonist 1
(CAS: 539813-69-9)

An agonist of PPAR α and PPAR γ

Muraglitazar
(CAS: 331741-94-7)

Muraglitazar is a peroxisome proliferator-activated receptor (PPAR) α/γ dual agonist(EC50s = 320 and 110 nM in vitro).