|Description||CP 615003 mesylate is a potent and selective GABAA receptor partial agonist potentially useful in treating generalized anxiety disorder.|
|Brife Description||GABAA receptor partial agonist|
|Related CAS||329016-45-7 (free base)|
|Application||potential treatment of anxiety|
Saclofen is a selective antagonist at GABAB receptors.
AA 29504 is a positive allosteric modulator of GABAA receptors with anxiolytic activity. It modulates both α4β3δ-containing extrasynaptic receptors and α1β3γ2S-...
PHP 501 trifluoroacetate
PHP 501 trifluoroacetate is potent GABAA antagonist (Ki = 0.0028 μM at rat GABAA receptors; IC50 = 0.024 μM at human α1β2γ2 GABAA-expressing tsA201 cells), with...
Ocinaplon is a GABAA receptor modulator and it can be used for the treatment of generalized anxiety disorder.
Cardiazole is a GABA(A) receptor antagonist, causes alterations in excitatory and inhibitory neurotransmitter systems.
Ginkgolide A is an extract from in Ginkgo biloba and a g-aminobutyric acid (GABA) antagonist with a Ki of 14.5 μM.
Etomidate is a GABAA receptor agonist, used as a short-acting anaesthetic agent or sedative.
(±)-Nipecotic acid is a nonselective GAT inhibitor that also induces GABA release through a process termed 'heteroexchange. IC50 = 8, 38, 106 and 2370 μM for hG...
TB 21007, as a nootropic drug, is a GABAA receptor inverse agonist selective for the α5-subtype (Ki values are 1.6, 16, 20 and 20 nM for α5, α2, α1 and α3 subty...
CGP 46381 is a selective GABAB receptor antagonist (IC50 = 4.9 μM).
NS 11394 is a drug with selectivity for the α3 and α5 subtypes. It acts as a subtype-selective positive allosteric modulator at GABAA receptors. It is used as a...
CL 218872 has been found to be a benzodiazepine agonist and has been found to exhibit anxiolytic and anticonvulsant activities.
ZAPA sulfate acts as an agonist at low affinity GABAA receptors and is thus a useful ligand to investigate GABA receptors linked to benzodiazepine receptors. ZA...
PZ-II-029,a pyrazoloquinolinone, was reported as the first postitive modulator of GABAA α6β3γ2 subtype functionally selective ligands to date.
TACA, the trans-isomer of CACA, is a potent GABAA and GABAC agonist, GABA uptake inhibitor and substrate for GABA-T. It also acts as a GABAA-ρ agonist.
β-CCB is an endogenous benzodiazepine binding inhibitor with proconvulsant and anxiogenic properties.
Chlormethiazole hydrochloride is the hydrochloride salt of chlormethiazole, which is a GABAA agonist. It is a useful research chemical and is used in the study ...
Nefiracetam is a GABAergic, cholinergic, and monoaminergic neuronal system enhancer for Ro 5-4864-induced convulsions.
SR 95531 hydrobromide
SR 95531 hydrobromide is a competitive GABAA receptor antagonist. SR 95531 differs from bicuculline that it selectively antagonizes GABA-induced Cl- currents bu...
U 89843A is a positive allosteric modulator of GABAA receptors. U 89843A potentiates GABA-induced Cl- currents in the α1β2γ2, α3β2γ2 and α6β2γ2 GABAA receptors....