CP 59430 - CAS 86329-06-8
Catalog number: 86329-06-8
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
C21H22N8O3
Molecular Weight:
434.45
COA:
Inquire
Targets:
Adrenergic Receptor
Description:
CP 59430 is an azide analog of prazosin. It is a selective alpha 1-adrenergic receptor antagonist.
Purity:
98%
Appearance:
Powder
Synonyms:
CP 59430; CP59430; CP-59430. 2-(4-(4-Azidobenzoyl)piperazin-1-yl)-4-amino-6,7-dimethoxyquinazoline
Solubility:
Soluble in DMSO
Storage:
-20℃ Freezer
MSDS:
Inquire
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Quantity:
Milligrams-Grams
InChIKey:
XHCZPSMUDVXSPQ-UHFFFAOYSA-N
InChI:
1S/C21H22N8O3/c1-31-17-11-15-16(12-18(17)32-2)24-21(25-19(15)22)29-9-7-28(8-10-29)20(30)13-3-5-14(6-4-13)26-27-23/h3-6,11-12H,7-10H2,1-2H3,(H2,22,24,25)
Canonical SMILES:
COc1cc2c(cc1OC)nc(nc2N)N3CCN(CC3)C(=O)c4ccc(cc4)N=[N+]=[N-]
1.Photoaffinity label for the alpha 1-adrenergic receptor: synthesis and effects on membrane and affinity-purified receptors.
Hess HJ;Graham RM;Homcy CJ Proc Natl Acad Sci U S A. 1983 Apr;80(8):2102-6.
An azide analog, 2-[4-(4-azidobenzoyl)piperazin-1-yl]-4-amino-6, 7-dimethoxyquinazoline (CP59,430), of the highly selective alpha 1-adrenergic receptor antagonist prazosin was synthesized and its effects on rat hepatic membrane and affinity-purified alpha 1-adrenergic receptor preparations were examined. CP59,430 behaved as a competitive antagonist before photolysis. When the membrane or purified preparations pretreated with CP59,430 were irradiated with UV light, CP59,430 behaved as a noncompetitive antagonist. Labeling of membrane alpha 1-adrenergic receptors was irreversible; repeated dialysis or washing could not reverse the photolysis-induced inactivation by CP59,430, whereas dialysis completely reversed the antagonism by the same concentration of the label prior to photolysis. Additionally, photolabeling of purified receptors was resistant to Sephadex G-50 chromatography, whereas in the absence of photolysis the same concentration of CP59,430 or prazosin (10 microM) could be readily removed by this procedure. CP59,430 appears to label specifically only alpha 1-adrenergic receptors because prazosin protected the membrane and purified receptors from photolysis-induced inactivation by CP59,430.
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