CP 544326 - CAS 752187-80-7
Catalog number: 752187-80-7
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C24H22N4O5S
Molecular Weight:
478.52
COA:
Inquire
Targets:
Prostaglandin Receptor
Description:
CP 544326, also known as taprenepag, is a potent and selective EP(2) receptor agonist. Its EC50 value is 2.8 nM. It is the active acid metabolite of the prodrug PF-04217329. It was successfully evaluated for its ocular hypotensive activity in a clinical study involving patients with primary open angle glaucoma.
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Purity:
98%
Related CAS:
1005549-94-9 (isopropyl)
Appearance:
Solid powder
Synonyms:
2-(3-((N-(4-(1H-pyrazol-1-yl)benzyl)pyridine-3-sulfonamido)methyl)phenoxy)acetic acid; CP-544326; CP544326; CP544326; Taprenepag; PF-0421732 metabolite
Solubility:
DMSO: > 31 mg/mL
Storage:
-20°C Freezer
MSDS:
Inquire
Application:
CP 544326 was successfully evaluated for its ocular hypotensive activity in a clinical study involving patients with primary open angle glaucoma.
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Quantity:
Grams to Kilograms
Boiling Point:
716.8±70.0 °C | Condition: Press: 760 Torr
Density:
1.34±0.1 g/cm3 | Condition: Temp: 20 °C Press: 760 Torr
InChIKey:
MFFBXYNKZHTCEY-UHFFFAOYSA-N
InChI:
1S/C24H22N4O5S/c29-24(30)18-33-22-5-1-4-20(14-22)17-27(34(31,32)23-6-2-11-25-15-23)16-19-7-9-21(10-8-19)28-13-3-12-26-28/h1-15H,16-18H2,(H,29,30)
Canonical SMILES:
O=C(O)COC1=CC=CC(CN(CC2=CC=C(N3N=CC=C3)C=C2)S(=O)(C4=CC=CN=C4)=O)=C1
1.Effect of PF-04217329 a prodrug of a selective prostaglandin EP(2) agonist on intraocular pressure in preclinical models of glaucoma.
Prasanna G1, Carreiro S, Anderson S, Gukasyan H, Sartnurak S, Younis H, Gale D, Xiang C, Wells P, Dinh D, Almaden C, Fortner J, Toris C, Niesman M, Lafontaine J, Krauss A. Exp Eye Res. 2011 Sep;93(3):256-64. doi: 10.1016/j.exer.2011.02.015. Epub 2011 Mar 3.
Better control of intraocular pressure (IOP) is the most effective way to preserve visual field function in glaucomatous patients. While prostaglandin FP analogs are leading the therapeutic intervention for glaucoma, new target classes also are being identified with new lead compounds being developed for IOP reduction. One target class currently being investigated includes the prostaglandin EP receptor agonists. Recently PF-04217329 (Taprenepag isopropyl), a prodrug of CP-544326 (active acid metabolite), a potent and selective EP(2) receptor agonist, was successfully evaluated for its ocular hypotensive activity in a clinical study involving patients with primary open angle glaucoma. In the current manuscript, the preclinical attributes of CP-544326 and PF-0421329 have been described. CP-544326 was found to be a potent and selective EP(2) agonist (IC(50) = 10 nM; EC(50) = 2.8 nM) whose corneal permeability and ocular bioavailability were significantly increased when the compound was dosed as the isopropyl ester prodrug, PF-04217329.
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CAS 752187-80-7 CP 544326

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