CP-533536 - CAS 223488-57-1
Catalog number:
223488-57-1
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C25H28N2O5S
Molecular Weight:
468.56
COA:
Inquire
Targets:
Prostaglandin Receptor
Description:
CP-533536, also called as Evatanepag, a 3-pyridyl sulfonamide compound, demonstrated excellent in vitro potency against prostaglandin E2 (PGE2) (induces local bone formation with EC50= 0.3 nM) and selectivity against a broad panel of other targets.
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Purity:
95%
Appearance:
Solid powder
Synonyms:
2-[3-[[(4-tert-butylphenyl)methyl-pyridin-3-ylsulfonylamino]methyl]phenoxy]acetic acid (3-((4-tert-butylbenzyl)-(pyridine-3-sulfonylamino)methyl)phenoxy)acetic acid CP-533,536 CP533536
Solubility:
Soluble to > 32 mg/mL in DMSO
Storage:
Store in a cool and dry place and at 0 - 4℃ for short term (days to weeks) or -82℃ for long term (months to years).
MSDS:
Inquire
Shelf Life:
2 years
Quantity:
Data not available, please inquire.
Boiling Point:
660.15ºC at 760 mmHg
Density:
1.262 g/cm3
InChIKey:
WOHRHWDYFNWPNG-UHFFFAOYSA-N
InChI:
1S/C25H28N2O5S/c1-25(2,3)21-11-9-19(10-12-21)16-27(33(30,31)23-8-5-13-26-15-23)17-20-6-4-7-22(14-20)32-18-24(28)29/h4-15H,16-18H2,1-3H3,(H,28,29)
Canonical SMILES:
CC(C)(C)C1=CC=C(C=C1)CN(CC2=CC(=CC=C2)OCC(=O)O)S(=O)(=O)C3=CN=CC=C3
1.Discovery of CP-533536: an EP2 receptor selective prostaglandin E2 (PGE2) agonist that induces local bone formation.
Cameron KO1, Lefker BA, Ke HZ, Li M, Zawistoski MP, Tjoa CM, Wright AS, DeNinno SL, Paralkar VM, Owen TA, Yu L, Thompson DD. Bioorg Med Chem Lett. 2009 Apr 1;19(7):2075-8. doi: 10.1016/j.bmcl.2009.01.059. Epub 2009 Jan 23.
Sulfonamides, exemplified by 3a, were identified as highly selective EP(2) agonists. Lead optimization led to the identification of CP-533536, 7f, a potent and selective EP(2) agonist. CP-533536 demonstrated the ability to heal fractures when administered locally as a single dose in rat models of fracture healing.
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CAS 223488-57-1 CP-533536

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