|Description||CP 461, belonging to a class of novel proapoptotic drugs with antineoplastic effect, specifically inhibit cyclic GMP phosphodiesterases but not cyclooxygenase-1 or -2.|
|Synonyms||CP 461; CP-461; CP461; OSI 461; UNII-68OJX9I7DT. N-benzyl-2-[6-fluoro-2-methyl-3-(pyridin-4-ylmethylidene)inden-1-yl]acetamide;hydrochloride; CAS: 227619-92-3 (CP-461 free base);|
FIPI, a derivative of halopemide, is a potent and selective phospholipase D (PLD) inhibitor with IC50 values of 20 and 25 nM for PLD2 and PLD1 respectively. It ...
An inhibitor of phosphodiesterase IV with potential for the treatment of asthma, COPD or other inflammatory diseases.
BAY 73-6691 is a phosphodiesterase inhibitor selective for the PDE9A subtype under the development of Bayer. It selectively inhibits human PDE9 with IC50 value ...
HA-130, an effective autotaxin (ATX) inhibitor, has been found to restrain the cell migration related to ATX in in an A2058 melanoma cells. IC50: 28 nM.
Gisadenafil besylate is a potent PDE5 inhibitor (IC50 = 1.23 nM) with >100-fold selectivity for PDE5 over PDE6. Gisadenafil besylate inhibits the breakdown of c...
Ibudilast is a nonselective inhibitor of cyclic nucleotide phosphodiesterase (PDE) which has been marketed for treating asthma. It crosses the blood-brain barri...
Olprinone is a selective phosphodiesterase 3 (PDE3) inhibitor. Olprinone is used as cardiotonic agent with positive inotropic and vasodilating effects. Olprinon...
Dipyridamole (Persantine) is a phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells.