|Description||CP-457920, also called as NGD 971, is a selective α5 GABAA receptor inverse agonist (Ki of ~ 1 ng/mL). CP-457920 was progressed into clinical studies for the treatment of Vascular dementia but discontinued.|
|Synonyms||N-benzyl-6-ethoxy-4-oxo-1H-1,5-naphthyridine-3-carboxamide; CP-457920; CP457920; CP 457920; UNII-13BME2F602; CP-457,920|
TPA023, also called as MK-0777, is a subtype-selective, mixed agonist-antagonist at GABAA receptor with anxiolytic and anticonvulsant effects.
CI966 is a highly potent and selective blocker of the GABA transporter 1 (GAT-1) with IC50 value of 0.26 µM acting as a central nervous system depressant. It ha...
Piperine (1-Piperoylpiperidine) is the alkaloid isolated from black pepper, activating transient receptor potential vanilloid type 1 receptor (TRPV1; EC50 = 38 ...
Progabide is a gamma-aminobutyric acid (GABA) antagonist. It has agonistic activity for both the GABAA and GABAB receptors. It has antiepileptic activity and is...
Emamectin Benzoate is the Emamectin derivative. Emamectin, also called as Proclaim, is widely used as an insecticide because of its chloride channel activation ...
Etomidate hydrochloride is a GABAA receptor agonist used for the induction of general anaesthesia.
Pipequaline is a non-selective GABAA receptor partial agonist that is potentially used as an anxiolytic drug of the nonbenzodiazepine class. It exhibits anxioly...
L-DABA, (L-2,4-Diaminobutyric acid) is a noncompetitive GABA transaminase inhibitor (IC50> 500 μM) with antitumor activity in vivo and in vitro.
(S)-(-)-4-Amino-2-hydroxybutyric acid is an analogue of γ-aminobutyric acid (GABA) that exhibits potential inhibitory activity on GABA binding and uptake by bra...
(+)-Bicuculline is a competitive antagonist of GABAA receptors with IC50 of 2 μM, also blocks Ca(2+)-activated potassium channels.
GS 39783 is an allosteric positive modulator of GABAB receptors, decreases cocaine self-administration, blocks the rewarding properties of nicotine and produces...
The hydrochloride of pipequaline. Pipequaline is a non-selective GABAA receptor partial agonist that is potentially used as an anxiolytic drug of the nonbenzodi...
CGP7930 is a positive allosteric modulator at the GABAB receptor. It has anxiolytic effects in animal studies, and has a synergistic effect with GABAB agonists ...
CGP 54626 hydrochloride
The hydrochloride salt form of CGP 54626, a dichloropheny derivative, has been found to be a GABAB receptor antagonist that could probably be effective as an an...
Lesogaberan is a potent and selective GABAB receptor agonist that limit the clinical use of baclofen for the treatment of GERD.
Etomidate is a GABAA receptor agonist, used as a short-acting anaesthetic agent or sedative.
L-655,708, an inverse agonist of α5 subunit involved in GABAA receptor, has been found to exhibit cognitive performance improvement in biological studies.
PWZ-029, a benzodiazepine derivative, has been found to be a GABAA receptors inverse agonist that could probably improve memory and exhibit sedative effects at ...
CP-409092 is a GABA(A) partial agonist developed for the treatment of General Anxiety Disorder (GAD) and presents an interesting phenomenon of human pharmacokin...
Primidone, a pyrimidinedione derivative, could be used as an anticonvulsant agent especially against epilepsy unspecified.