|Description||CP-457920, also called as NGD 971, is a selective α5 GABAA receptor inverse agonist (Ki of ~ 1 ng/mL). CP-457920 was progressed into clinical studies for the treatment of Vascular dementia but discontinued.|
|Synonyms||N-benzyl-6-ethoxy-4-oxo-1H-1,5-naphthyridine-3-carboxamide; CP-457920; CP457920; CP 457920; UNII-13BME2F602; CP-457,920|
U 93631 is a ligand at the picrotoxin site of GABA(A) receptors, allosterically antagonizing GABA-induced Cl- currents. U-93631 causes rapid decay of gamma-amin...
Emamectin Benzoate is the Emamectin derivative. Emamectin, also called as Proclaim, is widely used as an insecticide because of its chloride channel activation ...
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CGP52432 is a potent and selective GABAB receptor antagonist with IC50 value of 85 nM.
PWZ-029, a benzodiazepine derivative, has been found to be a GABAA receptors inverse agonist that could probably improve memory and exhibit sedative effects at ...
Etomidate hydrochloride is a GABAA receptor agonist used for the induction of general anaesthesia.
Arbaclofen, the R-enantiomer of baclofen, is a selective gamma-amino butyric acid type B receptor agonist used for autism spectrum disorder and fragile X syndro...
CP-457920, also called as NGD 971, is a selective α5 GABAA receptor inverse agonist (Ki of ~ 1 ng/mL). CP-457920 was progressed into clinical studies for the tr...
The hydrochloride of pipequaline. Pipequaline is a non-selective GABAA receptor partial agonist that is potentially used as an anxiolytic drug of the nonbenzodi...
An agonist of an allosteric binding site on the GABA Receptor subtype A
L-655,708, an inverse agonist of α5 subunit involved in GABAA receptor, has been found to exhibit cognitive performance improvement in biological studies.
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Progabide is a gamma-aminobutyric acid (GABA) antagonist. It has agonistic activity for both the GABAA and GABAB receptors. It has antiepileptic activity and is...
Etomidate is a GABAA receptor agonist, used as a short-acting anaesthetic agent or sedative.
Etifoxine, also called as HOE 36801 or Stresam, is a positive allosteric modulator of GABAreceptors that produces anxiolytic effects by preferentially modulatin...
Baclofen, an agonist of GABAB receptor, could be effective as a skeletal muscle relaxant and has been also found to have antispastic effect.
Bemegride is a central nervous system stimulant and antidote for barbiturate poisoning.
Indiplon acts as a high-affinity positive and orally active allosteric modulator of the GABAA receptor (Ki=1.2 nM in rat frontal cortex and Ki=1.7 nM and in cer...
(R)-baclofen a selective GABAB agonist.