CP 100356 - CAS 142716-85-6
Catalog number:
142716-85-6
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C31H36N4O6
Molecular Weight:
560.64
COA:
Inquire
Targets:
P-glycoprotein
Description:
CP 100356 is a high affinity P-glycoprotein inhibitor.Ki value is 58 nM for mouse Pgp1a and 94nMfor Pgp1b isoforms. It can Inhibit calcein-AM uptake in MDR1-transfected MDCKII cells with IC50 value of 0.5 μM and prazosin transport in BCRP-transfected MDCKII cells with IC50 value of 1.5 μM. Preclinical development for Cancer in USA was discontinued.
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Purity:
>98 %
Appearance:
Powder
Synonyms:
4-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-N-(2-(3,4-dimethoxyphenyl)ethyl)-6,7-dimethoxy-2-Quinazolinamine; 142715-48-8(hydrochloride)
Solubility:
Soluble in DMSO
Storage:
-20°C Freezer
MSDS:
Inquire
Application:
Cancer
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Quantity:
Milligrams-Grams
InChIKey:
PPMZZFZYBXDSRH-UHFFFAOYSA-N
InChI:
1S/C31H36N4O6/c1-36-24-8-7-19(13-25(24)37-2)9-11-32-31-33-23-17-29(41-6)28(40-5)16-22(23)30(34-31)35-12-10-20-14-26(38-3)27(39-4)15-21(20)18-35/h7-8,13-17H,9-12,18H2,1-6H3,(H,32,33,34)
Canonical SMILES:
n1c(nc(c2cc(c(cc12)OC)OC)N1Cc2cc(c(cc2CC1)OC)OC)NCCc1cc(c(cc1)OC)OC
Current Developer:
Originator Pfizer
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CAS 142716-85-6 CP 100356

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