|Targets||5-Lipoxygenase | COX|
|Description||A dual inhibitor of cylooxygenase and 5-lipoxygenase|
|Synonyms||Urea, N-[3-[5-[(4-fluorophenyl)methyl]-2-thienyl]-1-methyl-2-propyn-1-yl]-N-hydroxy-; 1-[4-[5-[(4-fluorophenyl)methyl]thiophen-2-yl]but-3-yn-2-yl]-1-hydroxyurea|
|Storage||Store in a cool and dry place (or refer to the Certificate of Analysis).|
|Boiling Point||506.7±60.0 ℃ at 760 Torr|
PGS-IN-1 is a potent inhibitor of prostaglandin synthetase (PGS) (IC50= 0.28 μM) and also an inhibitor of 5-lipoxygenase (IC50= 1.05 μM).
The prodrug Parecoxib as well as its active metabolite val have a specific affinity to the cannabinoid (CB) receptor measured in CB1-expressing HEK 293 cells an...
Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) analog of Diclofenac. It is used for the relief of pain and inflammation in rheumatoid arthritis, ...
A non-steroidal COX-1/COX-2 inhibitor; A nonsteroidal anti-inflammatory drug
A COX inhibitor for COX-1 and COX-2 with IC50 of 8.7 μM and 5.2 μM, respectively.
Tenoxicam is a non-steroidal anti-inflammatory drug (NSAID).Tenoxicam is a good HO. radicals scavenger with an IC50 of 56.7 μM
This active molecular is a potent 5-lipoxygenase inhibitor which was originated by Fujisawa company for treating asthma. No-Development was reported for asthma ...
A competitive inhibitor of COX-1 and COX-2
PF04191834 is a novel, potent and selective non-redox 5-lipoxygenase(5-LOX) inhibitor with an IC50 value of 229 +/- 20 nM. It inhibits 5-LOX in human blood cell...
Salicylic acid is a natural product extract from Willow bark, well known as an antiinflammatory inhibitor of cyclooxygenase activity. It is widely used in organ...
Zileuton is an orally active inhibitor of 5-lipoxygenase, and thus inhibits leukotrienes (LTB4, LTC4, LTD4, and LTE4) formation, used to decrease the symptoms o...
A salicylate and irreversible COX1 and COX2 inhibitor
An inhibitor of COX-1 and COX-2 with IC50 of 13 μM and 370 μM, respectively
A dual inhibitor of cylooxygenase and 5-lipoxygenase
Malotilate, diisopropyl 1,3-dithiol-2-ylidenemalonate, is a drug used for the treatment of liver cirrhosis.
This active molecular is a Leukotriene B4 antagonist. PD- 127443 is also a 5-lipoxygenase and cyclooxygenase inhibitor and it has been reported to have antiinfl...
Tenidap is one of the nonsteroidal antiinflammatory drugs. It is a COX1/2 and 5-lipoxygenase inhibitor. Tenidap preferentially inhibits COX-1 and IC50 value is...
Piroxicam is a non-selective COX inhibitor with an IC50 of 6 mM.
ML355 inhibits PAR-4 induced aggregation and calcium mobilization in human platelets and reduce 12-HETE in β-cells.
Flunixin is a non-steroidal anti-inflammatory drug (NSAID), analgesic, and antipyretic used in horses, cattle and pigs. It is often formulated as the meglumine ...