coumarin-SAHA - CAS 1260635-77-5
Molecular Formula:
C18H22N2O5
Molecular Weight:
346.4
COA:
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Application\Fluorophore:
Fluorescent Enzyme Substrates
Description:
Suberoylanilide hydroxamic acid (SAHA) is a histone deacetylase (HDAC) inhibitor. Coumarin-Suberoylanilide hydroxamic acid (c-SAHA) is a SAHA derivative where the anilino "cap" group is replaced by 7-amino-4-methylcoumarin to produce a fluorescent probe that competitively binds HDAC. coumarin-SAHA is used to determine binding affinities and dissociation off-rates of HDAC enzyme-inhibitor complexes.
Purity:
≥98%
Appearance:
Solid Powder
Synonyms:
Coumarin-Suberoylanilide Hydroxamic Acid; N1-hydroxy-N8-(4-methyl-2-oxo-2H-chromen-7-yl)-octanediamide
Storage:
Store at -20°C
MSDS:
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Excitation:
325 nm
Emission:
400 nm
InChIKey:
YSRCADVJNRJJAV-UHFFFAOYSA-N
InChI:
InChI=1S/C18H22N2O5/c1-12-10-18(23)25-15-11-13(8-9-14(12)15)19-16(21)6-4-2-3-5-7-17(22)20-24/h8-11,24H,2-7H2,1H3,(H,19,21)(H,20,22)
Canonical SMILES:
CC1=CC(=O)OC2=C1C=CC(=C2)NC(=O)CCCCCCC(=O)NO
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Chemical Structure

CAS 1260635-77-5 coumarin-SAHA

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