|Application\Fluorophore||Fluorescent Enzyme Substrates|
|Description||Suberoylanilide hydroxamic acid (SAHA) is a histone deacetylase (HDAC) inhibitor. Coumarin-Suberoylanilide hydroxamic acid (c-SAHA) is a SAHA derivative where the anilino "cap" group is replaced by 7-amino-4-methylcoumarin to produce a fluorescent probe that competitively binds HDAC. coumarin-SAHA is used to determine binding affinities and dissociation off-rates of HDAC enzyme-inhibitor complexes.|
|Synonyms||Coumarin-Suberoylanilide Hydroxamic Acid; N1-hydroxy-N8-(4-methyl-2-oxo-2H-chromen-7-yl)-octanediamide|
|Storage||Store at -20°C|
4-Methylumbelliferyl-β-D-glucuronide is a fluorogenic substrate for β-glucuronidase. 4-Methylumbelliferyl-β-D-glucuronide is cleaved by β-glucuronidase to relea...
Gly-Gly-AMC is a fluorogenic substrate for detecting the activity of bacterial proteases from P. aeruginosa and S. aureus. AMC (7-amino-4-methylcoumarin) is rel...
5-(6)-CDCFDA is a membrane-permeable substrate for esterase that can be hydrolyzed in cells to yield the fluorescent product. It can be used as an acidic pH sen...
Mca-PLGL-Dpa-AR-NH2 is a fluorogenic substrate for matrix metalloproteinase-2 (MMP-2) and MMP-7. 7-methoxycoumarin-4-acetyl (Mca) is released by cleavage of Mca...
ABTS Chromophore Diammonium Salt
ABTS Chromophore Diammonium Salt can inhibit catalase, a mammalian antioxidant enzyme which degrades hydrogen peroxide into water and oxygen species.
Dabcyl-RGVVNASSRLA-EDANS is a fluorogenic substrate for human cytomegalovirus (HCMV) protease. EDANS is released upon enzymatic cleavage by HCMV protease at the...
Dabcyl-GABA-PQGL-Glu(EDANS)-AK-NH2 is a fluorogenic substrate for matrix metalloproteinase-1 (MMP-1), MMP-2, MMP-3, and MMP-9. Upon enzymatic cleavage by MMP-1,...