Costunolide - CAS 553-21-9
Catalog number: 553-21-9
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C15H20O2
Molecular Weight:
232.32
COA:
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Targets:
Apoptosis Inducer
Description:
Costunolide, a natural sesquiterpene compound with multiple biological activities; inhibits FPTase with IC50 of 20 μM, also inhibits telomerase with IC50 of 65-90 μM.
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Purity:
>98%
Synonyms:
NSC 106404
MSDS:
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1.Costunolide Induces Apoptosis through Generation of ROS and Activation of P53 in Human Esophageal Cancer Eca-109 Cells.
Hua P1, Sun M2, Zhang G1, Zhang Y1, Song G1, Liu Z3, Li X4, Zhang X1, Li B5. J Biochem Mol Toxicol. 2016 Apr 14. doi: 10.1002/jbt.21810. [Epub ahead of print]
Costunolide is a sesquiterpene lactone, which possesses potent anti-cancer properties. However, there is little report about its effects on esophageal cancer. In our study, we investigated the effects of costunolide on the cell viability, cell cycle, and apoptosis in human esophageal cancer Eca-109 cells. It was found that costunolide inhibited the growth of Eca-109 cells in a dose-dependent manner, which was associated with the loss of mitochondrial membrane potential (Δψm ) and the production of ROS. Costunolide induced apoptosis of Eca-109 cells as well as cell cycle arrest in G1/S phase by upregulation of P53 and P21. Costunolide triggered apoptosis in esophageal cancer cells via the upregulation of Bax, downregulation of Bcl-2, and significant activation of caspase-3 and poly ADP-ribose polymerase. These effects were markedly abrogated when cells were pretreated with N-acetylcysteine, a specific reactive oxygen specie inhibitor. These results suggest that costunolide is a potential candidate for the treatment of esophageal cancer.
2.Costunolide Induces Apoptosis through Generation of ROS and Activation of P53 in Human Esophageal Cancer Eca-109 Cells.
Hua P1, Sun M2, Zhang G1, Zhang Y1, Song G1, Liu Z3, Li X4, Zhang X1, Li B5. J Biochem Mol Toxicol. 2016 Apr 14. doi: 10.1002/jbt.21810. [Epub ahead of print]
Costunolide is a sesquiterpene lactone, which possesses potent anti-cancer properties. However, there is little report about its effects on esophageal cancer. In our study, we investigated the effects of costunolide on the cell viability, cell cycle, and apoptosis in human esophageal cancer Eca-109 cells. It was found that costunolide inhibited the growth of Eca-109 cells in a dose-dependent manner, which was associated with the loss of mitochondrial membrane potential (Δψm ) and the production of ROS. Costunolide induced apoptosis of Eca-109 cells as well as cell cycle arrest in G1/S phase by upregulation of P53 and P21. Costunolide triggered apoptosis in esophageal cancer cells via the upregulation of Bax, downregulation of Bcl-2, and significant activation of caspase-3 and poly ADP-ribose polymerase. These effects were markedly abrogated when cells were pretreated with N-acetylcysteine, a specific reactive oxygen specie inhibitor. These results suggest that costunolide is a potential candidate for the treatment of esophageal cancer.
3.[Simultaneous Determination of Index Components in Wuwei Shaji Oral Liquid by HPLC].
Nan XM, Gu J, Tan R, Ren Y, Wang S. Zhong Yao Cai. 2015 Mar;38(3):615-7.
OBJECTIVE: To establish an HPLC method of detecting geniposide, mono-ammonium glycyrrhizinate, liquiritin, costunolide and dehydrocostus lactone in the Wuwei Shaji oral liquid simutaneously.
4.Simultaneous determination of three sesquiterpene lactones in Aucklandia lappa Decne by high-performance liquid chromatography.
Seo CS1, Shin HK1. Pharmacogn Mag. 2015 Jul-Sep;11(43):562-6. doi: 10.4103/0973-1296.160471.
BACKGROUND: Aucklandia lappa Decne, a well-known traditional herbal medicine, is used for the treatment of asthma, rheumatism, coughs, tuberculosis, and many other diseases.
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CAS 553-21-9 Costunolide

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