Corydaline - CAS 518-69-4
Catalog number: 518-69-4
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
Molecular Weight:
Corydaline, extracted from Corydalis ambigua, is one of the major active constituents in a new prokinetic botanical agent exhibiting the antiacetylcholinesterase.
Solid powder
Corydalin; BRN 0096972; BRN-0096972; BRN0096972; NSC 406036; NSC-406036; NSC406036; (13S,13aR)-2,3,9,10-tetramethoxy-13-methyl-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline;
Soluble in DMSO
Store at -20 °C
Antiacetylcholinesterase, antiallergic, antinociceptive,
Quality Standard:
Enterprise Standard
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Canonical SMILES:
1.Gender differences in corydaline pharmacokinetics in rats.
Jung JW1, Choi MR, Kwon YS, Jeong JS, Son M, Kang HE. Xenobiotica. 2015 May;45(5):456-63. doi: 10.3109/00498254.2014.988772. Epub 2014 Nov 28.
1. Corydaline, an isoquinoline alkaloid, is one of the major active constituents in a new prokinetic botanical agent, DA-9701. It has been recommended that preclinical pharmacokinetic studies of natural medicines include both genders. Therefore, in this study, the pharmacokinetics of corydaline in male and female rats was evaluated following intravenous and oral administration of pure corydaline or DA-9701. 2. After intravenous administration of corydaline, the area under the plasma concentration-time curve (AUC) was significantly greater (by 46.4%) in female rats compared to male rats due to a 29.3% reduction in non-renal clearance in female rats. The gender difference in corydaline hepatic metabolic clearance was supported by a significantly slower metabolism of corydaline in hepatic microsomes of female rats mediated via male-specific (CYP2C11 and CYP3A2) or male-dominant (CYP3A1) CYP isozymes. 3. Following oral administration of pure corydaline or DA-9701, the AUC and Cmax values of corydaline in female rats were significantly greater (by 793% and 466% increase for corydaline administration or by 501% and 143% increase for DA-9701 administration) than in male rats.
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CAS 518-69-4 Corydaline

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