Coptisine - CAS 3486-66-6
Catalog number: 3486-66-6
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C19H14NO4
Molecular Weight:
320.32
COA:
Inquire
Targets:
Others
Description:
Coptisine is an alkaloid extract from the herbs of Chelidonium majus L, has been found to reversibly inhibit Monoamine oxidase A in mice.
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Purity:
>98%
Appearance:
White Solid
Synonyms:
Bis[methylenedioxy]protoberberine; 7,8,13,13a-Tetradehydro-2,3-9,10-bis(methylenedioxy)berbinium;
Solubility:
Soluble in DMSO
Storage:
Store at -20 °C
MSDS:
Inquire
Application:
Coptisine treatment increases cell viability based on its reversal effect on the enhanced activity of Indoleamine 2,3-dioxygenase .
Quality Standard:
Enterprise Standard
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Quantity:
Milligrams-Grams
InChIKey:
XYHOBCMEDLZUMP-UHFFFAOYSA-N
InChI:
S/C19H14NO4/c1-2-16-19(24-10-21-16)14-8-20-4-3-12-6-17-18(23-9-22-17)7-13(12)15(20)5-11(1)14/h1-2,5-8H,3-4,9-10H2/q+1
Canonical SMILES:
C1C[N+]2=C(C=C3C=CC4=C(C3=C2)OCO4)C5=CC6=C(C=C51)OCO6
1.Coptisine from Coptis chinensis inhibits production of inflammatory mediators in lipopolysaccharide-stimulated RAW 264.7 murine macrophage cells.
Wu J1, Zhang H1, Hu B1, Yang L2, Wang P1, Wang F3, Meng X4. Eur J Pharmacol. 2016 Jun 5;780:106-14. doi: 10.1016/j.ejphar.2016.03.037. Epub 2016 Mar 24.
Coptis chinensis has been used for the treatment of inflammatory diseases in China and other Asian countries for centuries. However, the chemical constituents and mechanism underlying the anti-inflammatory activity of this medicinal plant are poorly understood. Here, coptisine, the main constituent of C. chinensis, was shown to potently inhibit the production of nitric oxide (NO) by suppressing the protein and mRNA expressions of inducible nitric oxide synthase (iNOS) in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages. Coptisine also inhibited the production of the pro-inflammatory cytokines interleukin-1β (IL-1β) and interleukin-6 (IL-6) by suppressing expression of cytokine mRNA. Coptisine suppressed the degradation of inhibitor of nuclear factor κBα (IκBα) and phosphorylation of extracellular signal-regulated kinase (ERK), c-Jun NH2-terminal kinase (JNK), p38 mitogen-activated protein kinase (MAPK), and phosphoinositide 3-kinase/Akt (PI3K/Akt).
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CAS 3486-66-6 Coptisine

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