Conquinine - CAS 56-54-2
Catalog number: 56-54-2
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C20H24N2O2
Molecular Weight:
324.42
COA:
Inquire
Targets:
Cytochrome P450
Description:
Conquinine is a Cytochrome P450 2D6 inhibitor. It is a dextrorotatory stereoisomer of quinine extracted from the bark of the Cinchona tree and similar plant species. It is an alkaloid with class 1A antiarrhythmic and antimalarial effects. It also blocks muscarinic and alpha-adrenergic neurotransmission. It stabilizes the neuronal membrane by binding to and inhibiting voltage-gated sodium channels, thus inhibiting the sodium influx required for the initiation and conduction of impulses resulting in an increase of the threshold for excitation and decreased depolarization during phase 0 of the action potential. It acts primarily as an intra-erythrocytic schizonticide through association with the heme polymer (hemazoin) in the acidic food vacuole of the parasite thereby preventing further polymerization by heme polymerase enzyme.
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Purity:
98%
Appearance:
White to Off-White Solid
Synonyms:
Quinidine;Chinidin;Pitayine;(+)-Quinidine;Quinidex;Chinidin;(S)-[(2R,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol
Solubility:
0.05 g/100 mL
Storage:
-20°C Freezer
MSDS:
Inquire
Application:
Conquinine is an alkaloid with class 1A antiarrhythmic and antimalarial effects. It also blocks muscarinic and alpha-adrenergic neurotransmission.
Quality Standard:
In-house standard
Quantity:
Kilograms to Tons
Boiling Point:
495.9±40.0 °C | Condition: Press: 760 Torr
Melting Point:
174 °C
Density:
1.21±0.1 g/cm3 | Condition: Temp: 20 °C Press: 760 Torr
InChIKey:
LOUPRKONTZGTKE-LHHVKLHASA-N
InChI:
InChI=1S/C20H24N2O2/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18/h3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3/t13-,14-,19+,20-/m0/s1
Canonical SMILES:
COC1=CC2=C(C=CN=C2C=C1)C(C3CC4CCN3CC4C=C)O
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

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CAS 56-54-2 Conquinine

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