|Description||Conquinine is a Cytochrome P450 2D6 inhibitor. It is a dextrorotatory stereoisomer of quinine extracted from the bark of the Cinchona tree and similar plant species. It is an alkaloid with class 1A antiarrhythmic and antimalarial effects. It also blocks muscarinic and alpha-adrenergic neurotransmission. It stabilizes the neuronal membrane by binding to and inhibiting voltage-gated sodium channels, thus inhibiting the sodium influx required for the initiation and conduction of impulses resulting in an increase of the threshold for excitation and decreased depolarization during phase 0 of the action potential. It acts primarily as an intra-erythrocytic schizonticide through association with the heme polymer (hemazoin) in the acidic food vacuole of the parasite thereby preventing further polymerization by heme polymerase enzyme.|
|Appearance||White to Off-White Solid|
|Solubility||0.05 g/100 mL|
|Application||Conquinine is an alkaloid with class 1A antiarrhythmic and antimalarial effects. It also blocks muscarinic and alpha-adrenergic neurotransmission.|
|Quality Standard||In-house standard|
|Quantity||Kilograms to Tons|
|Boiling Point||495.9±40.0 °C | Condition: Press: 760 Torr|
|Melting Point||174 °C|
|Density||1.21±0.1 g/cm3 | Condition: Temp: 20 °C Press: 760 Torr|
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