|Description||Combretastatin A4, under the IUPAC name 2-methoxy-5-[(Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol, inhibits tubulin polymerization (IC50= 2.2 μM). It has demonstrable antineoplastic activity (inhibit IMR32 (neuroblastoma): IC50= 2.16nM, Hs746T (gastric ca|
Anticoagulant: irreversible inhibits serine proteinase a-thrombine. Fluorocontaining phosphonate, synthetised.
Potent blocker of voltage-sensitive K+ channels (IC50 values are 0.1, 1.1 and 25 nM for KV1.3, KV1.1 and KV1.2 channels) respectively). Also inhibits Ca2+-activ...
Scopolamine, a nonselective muscarinic receptor antagonist, induces distinct behaviors of attenuated motility and C-like hyperactivity.
Synthetic., a GABA-gated chloride channel blocker, non-competitive GABA antagonist in mammals.
a nicotinic cholinoreceptor antagonist at the neuromuscular junction; curare-like ganglioblocker. Bis-quaternary quinuclidine derivative, , synthetic.
Non-selective K+ channel blocker.
Nitrodienamine, an inhibitor of Ca2+/Mg2+ ATPase.
A highly active peripheral M2-cholinoblocker alkaloid. Imperialine is extracted from Petilium eduardi and Petilium raddeanae (Liliaceae family)
Morphiceptin is a four amino acid peptide derived from the ß-casomorphin, a protein fragment itself derived from the digestion of milk protein casein. It is one...
Doxorubicin (Adriamycin) is an antibiotic agent that inhibits DNA topoisomerase II and induces DNA damage and apoptosis.
Long-acting, centrally active acetylcholinesterase inhibitor (IC50 = 410 nM) and allosteric potentiator at neuronal nicotinic ACh receptors. Prevents β-amyloid-...
A terpenoid complex ester , from plants of the Umbelliferae family, a substance presenting an estrogenic activity.
Phencarol is used in the biological studies of azoniabicyclooctanes as muscarinic acetylcholine receptor antagonists.
Tetrahydroberberine is a protoberberine alkaloid which potently block functional KATP channels natively expressed on midbrain dopamine neurons. Tetrahydroberber...
Harmaline is a fluorescent psychoactive indole alkaloid from the group of harmala alkaloids and beta-carbolines. It is the partially hydrogenated form of harmin...
Diazoxide is a potassium channel activator that causes local relaxation in smooth muscle by increasing membrane permeability to potassium ions. The cellular rel...
Triterpene glycoside Extracted from Dipsacus azureas
Trichodesmine is a pyrrolizidine alkaloid that has neurotoxic effects and is naturally found in Crotolaria argyptiaca, a shrub plant that is native to the south...
An inhibitor of serine proteinases of broad spectrum.
Cloflubicyne is a potent non-competitive GABA antagonist, convulsant, laboratory insecticide.