|Description||Codergocrine mesilate is a mixture of the methanesulfonate salts of three dihydrogenated ergot alkaloids. It binds with high affinity to the GABAA receptor Cl- channel, producing an allosteric interaction with the benzodiazepine site. It also interacts with central dopaminergic, serotonergic and adrenergic (α1) receptors. It displays antiproliferative activity and cognition-enhancing, anticonvulsant and sedative activity in vivo. It has been used to treat dementia and age-related cognitive impairment, such as in Alzheimer disease, as well as to aid in recovery after stroke. It may be used in conjunction with other cerebral enhancers like piracetam, with which it may act synergistically. It was developed by Albert Hofmann for Sandoz (now part of Novartis).|
|Appearance||White to off-white Solid|
|Synonyms||CCK 179, CCK-179, CCK179; Dihydroergotoxine mesylate;Dihydroergotoxine methanesulfonate;Dihydroergotoxine methanesulphonate;Dihydroergotoxine monomethanesulfonate(salt);Ergoloid mesylates|
|Solubility||DMSO: ≥ 31 mg/Ml|
|Application||Codergocrine mesilate displays antiproliferative activity and cognition-enhancing, anticonvulsant and sedative activity in vivo. It has been used to treat dementia and age-related cognitive impairment, such as in Alzheimer disease, as well as to aid in recovery after stroke. It may be used in conjunction with other cerebral enhancers like piracetam, with which it may act synergistically.|
|Quality Standard||In-house standard|
|Shelf Life||2 month in rt, long time|
|Boiling Point||899.5ºC at 760 mmHg|
|Current Developer||Codergocrine mesilate was developed by Albert Hofmann for Sandoz (now part of Novartis) and has been approved the listing.|
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