Codergocrine mesilate - CAS 8067-24-1
Catalog number: 8067-24-1
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
C20H29N3O5S
Molecular Weight:
423.53
COA:
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Targets:
Others
Description:
Codergocrine mesilate is a mixture of the methanesulfonate salts of three dihydrogenated ergot alkaloids. It binds with high affinity to the GABAA receptor Cl- channel, producing an allosteric interaction with the benzodiazepine site. It also interacts with central dopaminergic, serotonergic and adrenergic (α1) receptors. It displays antiproliferative activity and cognition-enhancing, anticonvulsant and sedative activity in vivo. It has been used to treat dementia and age-related cognitive impairment, such as in Alzheimer disease, as well as to aid in recovery after stroke. It may be used in conjunction with other cerebral enhancers like piracetam, with which it may act synergistically. It was developed by Albert Hofmann for Sandoz (now part of Novartis).
Purity:
95%
Appearance:
White to off-white Solid
Synonyms:
CCK 179, CCK-179, CCK179; Dihydroergotoxine mesylate;Dihydroergotoxine methanesulfonate;Dihydroergotoxine methanesulphonate;Dihydroergotoxine monomethanesulfonate(salt);Ergoloid mesylates
Solubility:
DMSO: ≥ 31 mg/Ml
Storage:
-20°C Freezer
MSDS:
Inquire
Application:
Codergocrine mesilate displays antiproliferative activity and cognition-enhancing, anticonvulsant and sedative activity in vivo. It has been used to treat dementia and age-related cognitive impairment, such as in Alzheimer disease, as well as to aid in recovery after stroke. It may be used in conjunction with other cerebral enhancers like piracetam, with which it may act synergistically.
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Quantity:
Milligrams-Grams
Boiling Point:
899.5ºC at 760 mmHg
Density:
1.34g/cm3
InChI:
InChI=1S/C19H25N3O2.CH4O3S/c1-11(10-23)21-19(24)13-6-15-14-4-3-5-16-18(14)12(8-20-16)7-17(15)22(2)9-13;1-5(2,3)4/h3-5,8,11,13,15,17,20,23H,6-7,9-10H2,1-2H3,(H,21,24);1H3,(H,2,3,4)/t11-,13+,15+,17+;/m0./s1
Current Developer:
Codergocrine mesilate was developed by Albert Hofmann for Sandoz (now part of Novartis) and has been approved the listing.
1.Validated liquid chromatography-tandem mass spectrometry method for simultaneous determination of clopamide, reserpine and dihydroergotoxine: Application to pharmacokinetics in human plasma.
Sharaf El-Din MM1, Nassar MW2, Attia KA2, Demellawy MA3, Kaddah MM4. J Pharm Biomed Anal. 2016 Mar 25;125:236-244. doi: 10.1016/j.jpba.2016.03.051. [Epub ahead of print]
A simple, sensitive and rapid high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) method was developed and validated for the simultaneous quantitation of clopamide, reserpine and dihydroergotoxine (ergoloid mesylates) in human plasma. Under basic conditions, liquid-liquid extraction using ethyl acetate was efficiently used for extraction of the analytes from plasma samples in presence of indapamide as internal standard (IS). The analytes were separated with isocratic elution on Phenomenex® Synergi Fusion-RP 80A column (50×4.6mm, 4μm). With positive ion electrospray ionization (ESI), the analytes were quantified and monitored on a triple quadrupole mass spectrometer using Multiple Reaction Monitoring (MRM) scanning mode. Satisfactory results regarding linearity, recovery, stability, accuracy and precision of the analytes were obtained. The method was linear in the concentration range of 0.04-30.00ng/mL for reserpine, 1-96.
2.Influence of dihydroergotoxine, bromocriptine, and ergotamine on penile erection in Wistar rats.
Radosavljevic M1, Pajovic B, Radunovic M, Radojevic N, Bjelogrlic B. J Androl. 2012 Sep-Oct;33(5):866-71. Epub 2012 Mar 22.
The pilot study presented was conducted to determine as to whether ergot alkaloids (alpha-adrenergic blockers) have a potential effect on penile erectile function. The influence of dihydroergotoxine, bromocriptine, and ergotamine was studied on the erection ability in intact, two-grade outbred male Wistar albino rats that were out of their estrous phase. The experimental animals were injected intrapenially with the substances under examination: dihydroergotoxine mesylate (0.1 mg/0.1 mL, 0.3 mg/0.1 mL, and 1 mg/0.1 mL), bromocriptine mesylate (0.3 mg/0.1 mL, 1 mg/0.1 mL, and 3 mg/0.1 mL), and ergotamine tartrate (0.1 mg/0.1 mL, 0.3 mg/0.1 mL, and 1mg/0.1 mL). Every dose was tested on a pattern of 30 rats. These mentioned substances were injected in the amount of 1 mm to the left of the proximal part of the superficial dorsal vein of the penis, in the region of the penis root. After injection, the animals were then observed within the next 90 minutes.
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CAS 8067-24-1 Codergocrine mesilate

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