|Description||Co 102862, also known as V102862, an orally active anticonvulsant with robust activity, is a potent, broad-spectrum state-dependent inhibitor of mammalian voltage-gated Na+ channels with ~ 80-fold higher affinity for inactivated Na+ channels compared to channels in the resting state.|
|Appearance||Pale yellow to white powder|
|Synonyms||[[4-(4-fluorophenoxy)phenyl]methylideneamino]urea; 4-(4-fluorophenoxy)benzaldehyde semicarbazone; Co 102862; Co-102862; FPhOBal semicarbazone; 181144-66-1; 2-(4-(4-Fluorophenoxy)benzylidene)hydrazinecarboxamide; Hydrazinecarboxamide, 2-[[4-(4-fluorophenoxy)phenyl]methylene]-|
|Solubility||Soluble to 100 mM in DMSO|
XEN907 is a novel spirooxindole NaV1.7 blocker with IC50 of 3 nM. It shows a further 10-fold increase in potency, which represents a promising structure for fur...
PH-064 is a sodium channel inhibitor. It is extracted from patent FR 2879460 A1.
Nav1.7 inhibitor is a Voltage-gated sodium channel inhibitor that have probable effect in pain therapy and local anaesthesia.
PF-05089771, a Nav1.7 channel blocker, has been studied to have potential effect in the treatment of chronic neuropathic pain. It is still under Phase II clinic...
TC-N 1752 is a state-dependent human NaV channel inhibitor (IC50 = 0.17, 0.3, 0.4, 1.1 and 1.6 μM at hNaV1.7, hNaV1.3, hNaV1.4, hNaV1.5 and hNav1.9, respectivel...
Huwentoxin IV is a selective NaV1.7 channel blocker with preference for neuronal NaV1.7, 1.2 and 1.3 (IC50 = 26, 150 and 338 nM, respectively). Huwentoxin IV in...
Disopyramide phosphate is an oral antiarrhythmic agent for the treatment of cardiac arrhythmias. Disopyramide is a sodium channel blocker and therefore classifi...
AM-2099 is a potent and selective inhibitor of voltage-gated sodium channel Nav1.7 (IC50= 0.16 μM) with excellent selectivity against hNav1.5 (IC50 > 30 uM).
Sodium Channel inhibitor 1
Sodium Channel inhibitor 1, a 3-Oxoisoindoline-1-carboxamide derivative, is an effective voltage-gated sodium channel blocker that could be used for pain treatm...
This active molecular is a human Nav1.7 voltage gated sodium channel inhibitor with the IC50 value of 28 nM. PF-04856264 inhibits the Nav channel by interacting...
Encainide Hydrochloride is a sodium channel blocker and class Ic antiarrhythmic agent. It is a non-chiral and benzanilide derivative. It blocks voltage-gated so...
Funapide is a Nav1.7 and Nav1.8 voltage-gated sodium channel inhibitor under the development by Xenon Pharmaceuticals and Teva Pharmaceutical Industries. It is ...
QX 314 chloride
QX 314 chloride, a membrane-impermeant lidocaine derivative, is a blocker of voltage-activated Na+ channels. QX-314 elicits a long-lasting decrease in the respo...
AM-36 is a potent blocker of batrachotoxinin (BTX)-sensitive Na+ channel binding in rat brain homogenates with an IC50 of 0.28 microM. As a unique neuroprotecti...
Cariporide, also known as HOE-642, is a selectiveNa+/H+exchange inhibitor, also known as the Na+/H+ antiporter, which functions to improve cellular integrity fo...
Proparacaine Hydrochloride is a topical ophthalmic anesthetic, acting by inhibiting the voltage-gated sodium channels. IC50(ED50): 3.4 mM.
Moricizine, a Phenothiazine derivative, is effective in suppressing premature ventricular contractions, couplets, and nonsustained ventricular tachycardia. And ...
Dyclonine HCl is a hydrochloride salt form of dyclonine which is an oral anaesthetic.
ICA-121431 is a potent and selective inhibitor of human NaV1.3 (IC50=13 nM) and NaV1.1 channels (IC50=23 nM) with 1,000 fold selectivity against other resistant...
Nav1.7 blocker 24
Nav1.7 blocker 24 is a sodium channel blocker with selectivity for the voltage-gated Nav1.7 (pIC50 = 6.75).