Clozapine - CAS 5786-21-0
Catalog number: 5786-21-0
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C18H19ClN4
Molecular Weight:
326.82
COA:
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Targets:
Dopamine Receptor
Description:
Clozapine is an atypical antipsychotic drug by acting as a 5-HT antagonist, used in the treatment of schizophrenia.
Purity:
>98%
Synonyms:
HF 1854, LX 100-129
MSDS:
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InChIKey:
ZUXABONWMNSFBN-UHFFFAOYSA-N
InChI:
InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,21H,8-11H2,1H3
Canonical SMILES:
CN1CCN(CC1)C2=C3C=CC=CC3=NC4=C(N2)C=C(C=C4)Cl
1.Very Low Dose Amitriptyline for Clozapine-Associated Sialorrhea.
Sinha S1, Simlai J2, Praharaj SK3. Curr Drug Saf. 2016 Apr 26. [Epub ahead of print]
Clozapine is the antipsychotic of choice for resistant schizophrenia, but its widespread use is limited by adverse effects. Sialorrhea is a common and troublesome adverse effect seen with clozapine which leads to poor compliance. Several treatment strategies are advocated, no single treatment is considered superior. Amitriptyline, a tricyclic antidepressant, has been found to be useful for clozapine-associated sialorrhea at 87-100 mg per day. We report the effect of very low dose amitriptyline (10 mg per day) in a patient with clozapine-associated sialorrhea. There was rapid and complete resolution of sialorrhea after three days without any emergent adverse effect.
2.Use of Clozapine for Borderline Personality Disorder: A Case Report.
Amamou B1, Salah WB1, Mhalla A1, Benzarti N1, Elloumi H1, Zaafrane F1, Gaha L1. Clin Psychopharmacol Neurosci. 2016 May 31;14(2):226-8. doi: 10.9758/cpn.2016.14.2.226.
Patients with borderline personality disorder (BPD) show significant impairment in functioning, particularly in the interpersonal and social domains. Prior reports suggest that clozapine may be effective in the management of BPD. We present the case of a patient with BPD who experienced persistent suicidal ideation and was treated with clozapine at a state psychiatric hospital. After treatment failure with other psychotropic medications, clozapine medication was initiated; not only did suicidal ideation cease, but social and professional functioning also greatly improved to the point of no longer requiring intensive levels of observation or restrictive procedures. Clozapine appears to be efficacious in the management of suicide attempts and self-injurious behavior. Moreover, it appears to be promising as a therapeutic measure for ameliorating the global functioning of patients with severe BPD. Larger, randomized, blinded, and controlled prospective studies are needed to confirm these findings and to determine optimal dosage.
3.Late Onset Agranulocytosis with Clozapine Associated with HLA DR4 Responding to Treatment with Granulocyte Colony-stimulating Factor: A Case Report and Review of Literature.
Singh A1, Grover S1, Malhotra P2, Varma SC2. Clin Psychopharmacol Neurosci. 2016 May 31;14(2):212-7. doi: 10.9758/cpn.2016.14.2.212.
Agranulocytosis as a side effect of clozapine has been reported to be associated with initial phases of treatment, i.e., first six months. Agranulocytosis with clozapine during the initial phases of treatment has been linked to genetic vulnerability in the form of variations in the human leukocyte-antigen haplotypes. However, there is limited literature on late onset agranulocytosis with clozapine and this has very rarely been linked to human leukocyte-antigen haplotypes vulnerability. In this report we review the existing data on late onset agranulocytosis with clozapine and describe the case of a young man, who developed agranulocytosis with clozapine after 35 months of treatment and was found to have genetic vulnerability in form of being positive for HLA DR4. This case highlights underlying autoimmune immune mechanism in clozapine-induced agranulocytosis and the need for frequent blood count monitoring on clozapine even after the initial 6 months of starting treatment especially in patients with genetic vulnerability to develop this condition.
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CAS 5786-21-0 Clozapine

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