Closantel Sodium - CAS 61438-64-0
Catalog number:
61438-64-0
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C22 H13 Cl2I2N2O2.Na
Molecular Weight:
685.06
COA:
Inquire
Targets:
Antiparasitic
Description:
Closantel is a salicylanilide anthelmintic compound; exhibits different anthelmintic spectra and apparent toxicity in mammals.
Publictions citing BOC Sciences Products
  • >> More
Purity:
>98%
MSDS:
Inquire
1.Molecular identification and seasonal infections of species of Fasciola in ruminants from two provinces in China.
Yuan W1, Liu JM1, Lu K1, Li H1, Duan MM1, Feng JT1, Hong Y1, Liu YP2, Zhou Y3, Tong LB4, Lu J5, Zhu CG1, Jin YM1, Cheng GF1, Lin JJ1. J Helminthol. 2016 May;90(3):359-63. doi: 10.1017/S0022149X15000383. Epub 2015 Jun 30.
We determined the prevalence and seasonality of infections by Fasciola of goats and bovine species (cattle and water buffalo) in Hubei and Anhui provinces of China. Faecal samples were collected at 2- to 3-month intervals from 200 goats in Hubei province and from 152 bovine species in Anhui province. All faecal samples were examined for the presence of parasites. We determined the nucleotide sequences of the first and second internal transcribed spacers (ITS-1 and ITS-2) of the nuclear ribosomal DNA (rDNA) of 39 Fasciola worms from Anhui province. The prevalence of Fasciola infection in goats ranged between 3.5 and 37.0%, with mean eggs per gram (EPG) ranging between 29.0 and 166.0. Prevalence and EPG exhibited downward trends over time with significant differences. The prevalence of Fasciola infection in cattle ranged between 13.3 and 46.2% (mean EPG, 36.4-100.0), and that of water buffalo ranged between 10.3 and 35.4% (mean EPG, 25.0-89.
2.Discovery of Novel SPAK Inhibitors That Block WNK Kinase Signaling to Cation Chloride Transporters.
Kikuchi E1, Mori T1, Zeniya M1, Isobe K1, Ishigami-Yuasa M2, Fujii S3, Kagechika H4, Ishihara T5, Mizushima T5, Sasaki S1, Sohara E1, Rai T1, Uchida S6. J Am Soc Nephrol. 2015 Jul;26(7):1525-36. doi: 10.1681/ASN.2014060560. Epub 2014 Nov 5.
Upon activation by with-no-lysine kinases, STE20/SPS1-related proline-alanine-rich protein kinase (SPAK) phosphorylates and activates SLC12A transporters such as the Na(+)-Cl(-) cotransporter (NCC) and Na(+)-K(+)-2Cl(-) cotransporter type 1 (NKCC1) and type 2 (NKCC2); these transporters have important roles in regulating BP through NaCl reabsorption and vasoconstriction. SPAK knockout mice are viable and display hypotension with decreased activity (phosphorylation) of NCC and NKCC1 in the kidneys and aorta, respectively. Therefore, agents that inhibit SPAK activity could be a new class of antihypertensive drugs with dual actions (i.e., NaCl diuresis and vasodilation). In this study, we developed a new ELISA-based screening system to find novel SPAK inhibitors and screened >20,000 small-molecule compounds. Furthermore, we used a drug repositioning strategy to identify existing drugs that inhibit SPAK activity. As a result, we discovered one small-molecule compound (Stock 1S-14279) and an antiparasitic agent (Closantel) that inhibited SPAK-regulated phosphorylation and activation of NCC and NKCC1 in vitro and in mice.
3.Overberg research projects. XV. The efficacy of different anthelmintics against field strains of nematode parasites of sheep in the southern Cape Province.
Louw JP1, Reinecke RK. J S Afr Vet Assoc. 1993 Jun;64(2):71-5.
Controlled anthelmintic tests and faecal egg count reduction tests were carried out on natural infections of nematode parasites in sheep on 4 farms in the southern Cape Province. Albendazole, fenbendazole, ivermectin, levamisole, morantel citrate and a combination of albendazole and closantel sodium were tested. Every farm harboured anthelmintic resistant nematode parasites. Adult as well as immature Teladorsagia spp. were resistant to albendazole and fenbendazole, immature Teladorsagia spp. to albendazole/closantel, adult and immature Nematodirus spp. to albendazole/closantel and adult Nematodirus spp. to fenbendazole.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Antiparasitic Products


CAS 521-74-4 Broxyquinoline

Broxyquinoline
(CAS: 521-74-4)

Broxyquinoline is an antiprotozoal agent and able to release oxygen free radicals from the water in mucous membranes.

CAS 3818-50-6 Bephenium hydroxynaphthoate

Bephenium hydroxynaphthoate
(CAS: 3818-50-6)

Bephenium hydroxynaphthoate is an anthelmintic agent formerly used in the treatment of hookworm infections and ascariasis, which belongs to B-type AChR activato...

CAS 58066-85-6 Miltefosine

Miltefosine
(CAS: 58066-85-6)

Miltefosine inhibits PI3K/Akt activity with ED50 of 17.2 μM and 8.1 μM in carcinoma cell lines A431 and HeLa, first oral drug for Visceral leishmaniasis, effect...

CAS 6506-37-2 Nimorazole

Nimorazole
(CAS: 6506-37-2)

Nimorazole is a nitroimidazole anti-infective. It significantly improves the effect of radiotherapeutic management of supraglottic and pharynx tumors and can be...

CAS 1861-32-1 Chlorthal-dimethyl

Chlorthal-dimethyl
(CAS: 1861-32-1)

Chlorthal-dimethyl, also called as Dacthal, it is metabolized in animals to monomethyl ester and chlorthal which are eliminated in urine and used as a pesticide...

CAS 100-33-4 Pentamidine

Pentamidine
(CAS: 100-33-4)

Pentamidine is an antimicrobial agent.

CAS 129496-10-2 Milbemycin Oxime

Milbemycin Oxime
(CAS: 129496-10-2)

Milbemycin oxime, a mixture of Milbemycin Oxime A3 and A4, is an antiparasitic and could be effectively used as an veterinary drug.

CAS 40596-69-8 Methoprene

Methoprene
(CAS: 40596-69-8)

Methoprene, is a juvenile hormone (JH) analog which can be used as an a biological pesticide.

CAS 3383-96-8 Temefos

Temefos
(CAS: 3383-96-8)

Temefos or temephos is an an insecticide used to to treat water infested in aquatic situations and on domestic pets.

CAS 23110-15-8 Fumagillin

Fumagillin
(CAS: 23110-15-8)

Fumagillin is a compound isolated from the fungus Aspergillus fumigatus. Fumagillin is an antimicrobial agent used in the treatment of microsporidiosis. Fumagil...

CAS 7681-76-7 Ronidazole

Ronidazole
(CAS: 7681-76-7)

Ronidazole is an antiprotozoal agent.

CAS 148-01-6 Dinitolmide

Dinitolmide
(CAS: 148-01-6)

Dinitolmide is a broad-spectrum anticoccidial drug.

CAS 3736-81-0 Diloxanide furoate

Diloxanide furoate
(CAS: 3736-81-0)

Diloxanide furoate is an ambecide used to treat infection with amoebas.

CAS 52645-53-1 Permethrin

Permethrin
(CAS: 52645-53-1)

Permethrin is a synthetic pyrethroid insectide, affecting neuron membranes by prolonging sodium channel activation.

CAS 121-25-5 Amprolium

Amprolium
(CAS: 121-25-5)

Amprolium, a thiamine derivative, could be commonly useful in poultry as a coccidiostat.

CAS 83905-01-5 Azithromycin

Azithromycin
(CAS: 83905-01-5)

Azithromycin is an antibiotic for inhibition of parasite growth with IC50 of 8.4 μM.

CAS 33564-30-6 Cefoxitin sodium

Cefoxitin sodium
(CAS: 33564-30-6)

Cefoxitin is is derived from cephamycin C, a semi-synthetic, broad-spectrum cepha antibiotic often grouped with the second-generation cephalosporins.

CAS 55268-74-1 Praziquantel

Praziquantel
(CAS: 55268-74-1)

Praziquantel, marketed as Biltricide, is an anthelmintic used in humans and animals for the treatment of tapeworms and flukes. Specifically, it is effective aga...

CAS 2277-92-1 Oxyclozanide

Oxyclozanide
(CAS: 2277-92-1)

Oxyclozanide is a salicylanilide anthelmintic used in the treatment and control of Fascioliasis in ruminants mainly domestic animals like Cattle, Sheep and Goat...

CAS 60200-06-8 Clorsulon

Clorsulon
(CAS: 60200-06-8)

Clorsulon is used in the treatment of Fasciola hepatica infections in calves and sheep.

Chemical Structure

CAS 61438-64-0 Closantel Sodium

Quick Inquiry

Verification code

Featured Items