Cloquintocet-mexyl - CAS 99607-70-2
Catalog number:
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
Molecular Weight:
Cloquintocet-mexyl is a herbicide. It is used to control coarse annual grass of the family poaceae (gramineae). lt was developed by the swiss ciba geigy in the 1980s and the patent has expired.
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Solid powder
1-Methylhexyl (5-chloroquinolin-8-yloxy)acetate;Cloquintocet-1 heptan-2-yl 2-(5-chloroquinolin-8-yl)oxyacetate;Acetic acid,[(5-chloro-8-quinolinyl)oxy]-,1- methylhexyl ester;CGA 185072;Heptan-2-yl 2-((5-chloroquinolin-8-yl)oxy)acetate
H2O: 0.4-0.6 mg/L
Cloquintocet-mexyl is a herbicide.
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Kilogram to ton
Boiling Point:
448.4ºC at 760 mmHg
Melting Point:
448.4±30.0 °C | Condition: Press: 760 Torr
1.163±0.06 g/cm3 | Condition: Temp: 20 °C Press: 760 Torr
Canonical SMILES:
Current Developer:
Cloquintocet-mexyl was developed by the swiss ciba geigy in the 1980s and the patent has expired.
1.Metabolism of the14C-labeled herbicide clodinafop-propargyl in plant cell cultures of wheat and tobacco.
Luks AK1, Wijntjes C1, Schmidt B1. J Environ Sci Health B. 2016 Feb;51(2):71-80. Epub 2015 Nov 17.
The metabolism of 14C-clodinafop-propargyl (CfP) was examined in cell cultures of wheat (Triticum aestivum L. cv. 'Heines Koga II') and tobacco (Nicotiana tabacum L.). Besides the non-transgenic tobacco culture, cultures transformed separately with cDNA of human cytochrome P450-monooxygenases (P450s) CYP1A1, CYP1A2, CYP3A4, CYP2B6 and CYP2C19 were examined. Experiments with wheat were executed in the presence and absence of safener cloquintocet-mexyl (CqM). After 48 h of incubation, only about 10% of applied 14C was found in media (both tobacco and wheat). Non-extractable residues of 14C-CfP in wheat cells were 16.54% (without CqM) and 30.87% (with CqM). In all tobacco cultures, 82.41-92.46% of applied radioactivity was recovered in cell extracts. In contrast to wheat, non-extractable residues amounted only to 1.50-2.82%. As determined by radio-thin layer chromatography (TLC) and -high-performance liquid chromatography (HPLC), the parent CfP was not found in the cell extracts of wheat; in tobacco cell extracts, only traces of CfP were detected.
2.Festuca arundinacea, glutathione S-transferase and herbicide safeners: a preliminary case study to reduce herbicidal pollution.
Scarponi L1, Del Buono D. J Environ Sci Health B. 2009 Nov;44(8):805-9. doi: 10.1080/03601230903238400.
The expression of glutathione S-transferase (GST) activity in Festuca arundinacea was investigated in response to the following herbicide safeners: benoxacor, cloquintocet-mexyl, fenchlorazol-ethyl, fenclorim, fluxofenim and oxabetrinil. All the above compounds enhanced the GST activity tested towards the "model" substrate 1-chloro-2,4-dinitrobenzene (CDNB). Assays of GST activity towards the herbicides terbuthylazine (N(2)-tert-butyl-6-chloro-N(4)-ethyl-1,3,5-triazine-2,4-diamine) and butachlor (N-butoxymethyl-2-chloro-2',6'-diethylacetanilide) as substrates also showed the ability of the safeners to enhance the enzyme activity towards both these herbicides, with the exception of cloquintocet-mexyl for the enzyme activity towards butachlor. As a consequence of the above effects at a macro-scale level, decreased herbicide accumulation and persistence were ascertained in response to the addition of the safener benoxacor to both terbuthylazine and butachlor treatments.
3.The impact of uptake, translocation and metabolism on the differential selectivity between blackgrass and wheat for the herbicide pyroxsulam.
DeBoer GJ1, Thornburgh S, Gilbert J, Gast RE. Pest Manag Sci. 2011 Mar;67(3):279-86. doi: 10.1002/ps.2062. Epub 2010 Nov 22.
BACKGROUND: Wheat shows selectivity to pyroxsulam, a new broad-spectrum herbicide with high activity on blackgrass. Studies were performed to establish whether uptake, translocation or metabolism were responsible for the differential activity in wheat compared with blackgrass. In addition, the effect of the safener cloquintocet-mexyl on metabolism was evaluated in wheat and blackgrass shoots.
4.Cytochrome P450 Inhibitors Reduce Creeping Bentgrass (Agrostis stolonifera) Tolerance to Topramezone.
Elmore MT1, Brosnan JT2, Armel GR2, Kopsell DA2, Best MD3, Mueller TC2, Sorochan JC2. PLoS One. 2015 Jul 17;10(7):e0130947. doi: 10.1371/journal.pone.0130947. eCollection 2015.
Creeping bentgrass (Agrostis stolonifera L.) is moderately tolerant to the p-hydroxyphenylpyruvate dioxygenase-inhibiting herbicide topramezone. However, the contribution of plant metabolism of topramezone to this tolerance is unknown. Experiments were conducted to determine if known cytochrome P450 monooxygenase inhibitors 1-aminobenzotriazole (ABT) and malathion alone or in combination with the herbicide safener cloquintocet-mexyl influence creeping bentgrass tolerance to topramezone. Creeping bentgrass in hydroponic culture was treated with ABT (70 μM), malathion (70 μm and 1000 g ha(-1)), or cloquintocet-mexyl (70 μM and 1000 g ha(-1)) prior to topramezone (8 g ha(-1)) application. Topramezone-induced injury to creeping bentgrass increased from 22% when applied alone to 79 and 41% when applied with malathion or ABT, respectively. Cloquintocet-mexyl (70 μM and 1000 g ha(-1)) reduced topramezone injury to 1% and increased creeping bentgrass biomass and PSII quantum yield.
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CAS 99607-70-2 Cloquintocet-mexyl

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