(+)-Cloprostenol sodium salt - CAS 62561-03-9
Catalog number:
62561-03-9
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C22H28ClO6Na
Molecular Weight:
446.90
COA:
Inquire
Targets:
Prostaglandin Receptor
Description:
(+)-Cloprostenol sodium salt is the d-enantiomer of Cloprostenol, which is an aryl-oxymethyl analog of prostaglandin F2α. It has luteolytic effects and is used for the synchronization of estrus in cattle. It is also an FP receptor agonist.
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Purity:
98%
Appearance:
White to Off-White Solid
Synonyms:
(5Z)-7-[(1R,2R,3R,5S)-2-[(1E,3R)-4-(3-Chlorophenoxy)-3-hydroxy-1-buten-1-yl]-3,5-dihydroxycyclopentyl]-5-heptenoic Acid Sodium Salt;[1R-[1α(Z),2β(1E,3R*),3α,5α]]- 7-[2-[4-(3-Chlorophenoxy)-3-hydroxy-1-butenyl]-3,5-dihydroxycyclopentyl]-5-heptenoic Acid So
Solubility:
DMSO, Water
Storage:
Hygroscopic, -20°C Freezer, Under inert atmosphere
MSDS:
Inquire
Application:
(+)-Cloprostenol sodium salt has luteolytic effects and is used for the synchronization of estrus in cattle.
Quality Standard:
In-house standard
Quantity:
Grams to Kilograms
Boiling Point:
628 °C at 760 mmHg
Melting Point:
>62°C (dec.)
InChIKey:
IFEJLMHZNQJGQU-AMTBJRPQSA-M
InChI:
InChI=1S/C22H29ClO6.Na/c23-15-6-5-7-17(12-15)29-14-16(24)10-11-19-18(20(25)13-21(19)26)8-3-1-2-4-9-22(27)28;/h1,3,5-7,10-12,16,18-21,24-26H,2,4,8-9,13-14H2,(H,27,28);/q;+1/p-1/b3-1-,11-10+;/t16?,18-,19-,20+,21-;/m1./s1
Canonical SMILES:
C1C(C(C(C1O)C=CC(COC2=CC(=CC=C2)Cl)O)CC=CCCCC(=O)[O-])O.[Na+]
1.Manipulation of estrous cycle in dwarf goat (Capra hircus) using estrumate under different management conditions.
Khanum SA1, Hussain M, Kausar R. Anim Reprod Sci. 2006 Mar;92(1-2):97-106. Epub 2005 Jul 18.
A study was conducted to elucidate the effectiveness of exogenous estrumate (prostaglandin F(2alpha)) treatment as a synchronizing agent for Dwarf goats and to establish the progesterone levels at different reproductive stages under two different environmental and nutritional conditions. Female Dwarf goats of various ages were raised, 10 each at two sites, viz. the Bio-Saline Research Substation (BSRS), Lahore and at the Nuclear Institute for Agriculture and Biology (NIAB), Faisalabad. The animals at the NIAB farm were reared on non-saline soil under normal grazing conditions, while the other animal lot was raised on salt-affected lands at the BSRS, Lahore and was fed on non-conventional fodders produced by salt-affected lands. The animals received two intramuscular doses (0.5 ml each) of estrumate (125 microg/ml) at 10 days interval. Nineteen of the 20 animals exhibited estrus after 56-72 h of the second injection of estrumate. The mean progesterone concentration in the NIAB and BSRS lots was 2.
2.The use of electrochemically activated saline as a uterine instillation in pony mares.
Annandale CH1, Schulman ML, Kirkpatrick RD. J S Afr Vet Assoc. 2008 Mar;79(1):36-8.
Twelve pony mares were randomly assigned to either a control or a treatment group and inseminated with fresh, raw semen from a single stallion of known fertility in a cross-over trial design. Pregnancy was diagnosed by transrectal ultrasound 12-14 days post-ovulation and then terminated by administration of a luteolytic dose of cloprostenol. Treatment mares received a uterine instillation of 100 ml of electrochemically activated (ECA) saline 4-12 hours post-insemination. Control mares received no treatment post-insemination. Per cycle pregnancy rate was 58.3 % in the control group and 50 % in the treatment group. There was no statistical difference (P = 1.000) in pregnancy rate between the 2 groups. The principles of ECA and applications of ECA saline are discussed.
3.Bimatoprost versus Mometasone Furoate in the Treatment of Scalp Alopecia Areata: A Pilot Study.
Zaher H1, Gawdat HI, Hegazy RA, Hassan M. Dermatology. 2015;230(4):308-13. doi: 10.1159/000371416. Epub 2015 Mar 4.
BACKGROUND: Alopecia areata (AA) is an immune-mediated disease that targets anagen hair follicles. Despite various therapeutic options, there is no cure for AA. Prostaglandin analogues have been recognized as being capable of inducing hypertrichosis.
4.Effects of glaucoma medications and preservatives on cultured human trabecular meshwork and non-pigmented ciliary epithelial cell lines.
Ammar DA1, Kahook MY. Br J Ophthalmol. 2011 Oct;95(10):1466-9. doi: 10.1136/bjophthalmol-2011-300012. Epub 2011 May 20.
AIMS: We investigated the potential cytotoxicity of various topical ophthalmic glaucoma formulations containing different preservatives in cultured human trabecular meshwork (TM) and non-pigmented ciliary epithelial (NPCE) cell lines.
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CAS 62561-03-9 (+)-Cloprostenol sodium salt

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