Clopidol - CAS 2971-90-6
Catalog number: 2971-90-6
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C7H7Cl2NO
Molecular Weight:
192.04
COA:
Inquire
Targets:
Antiparasitic
Description:
Clopidol is an organic compound that is used as in veterinary medicine as a coccidiostat. It is prepared industrially by a multistep process from dehydroacetic acid.
Publictions citing BOC Sciences Products
  • >> More
Purity:
>98%
Synonyms:
WR 61112
MSDS:
Inquire
1.Determination of fifteen coccidiostats in feed at carry-over levels using liquid chromatography-mass spectrometry.
Pietruk K1, Olejnik M2, Jedziniak P1, Szprengier-Juszkiewicz T1. J Pharm Biomed Anal. 2015 Aug 10;112:50-9. doi: 10.1016/j.jpba.2015.03.019. Epub 2015 Apr 22.
A multi-residue method has been developed and validated for the simultaneous determination of authorized (decoquinate, diclazuril, halofuginone, lasalocid, maduramicin, monensin, narasin, nicarbazin, robenidine, salinomycin and semduramicin) and non-authorized (amprolium, clopidol, ethopabate and toltrazuril) coccidiostats in animal feed. Feed samples were extracted with basic followed by acidified solution in methanol and, after centrifugation, were injected directly into LC-MS/MS system. Detection was performed in selected reaction monitoring mode with both positive and negative electrospray ionization. The time efficient validation experiment has verified the robustness of a method in different types of feed and on two separate LC-MS/MS instruments. The comparison of different quantification methods demonstrated that, against expectations, the standard addition did not prove better in comparison with matrix-matched calibration curve. Although the sample preparation was very easy, the observed matrix effects were not significant for the most part but they could explain the problems with the quantification of some coccidiostats.
2.[Simultaneous determination of clopidol, sulfonamide and quinolone residues in chickens by ultra performance liquid chromatography-tandem mass spectrometry].
Song W, Hu Y, Han F, Lü Y, Zheng P, Zhou F, Chen X, Qiu J, Zhou X. Se Pu. 2013 Dec;31(12):1161-6.
An analytical method for the simultaneous determination of clopidol, sulfadiazine, sulfamethazine, sulfametoxydiazine, sulfamethoxypyridazine, norfloxacin, ofloxacin, ciprofloxacin, enrofloxacin in chickens by ultra performance liquid chromatography coupled with tandem quadrupole mass spectrometry (UPLC-MS/MS) in positive ion mode with multiple reaction monitoring (MRM) has been developed and validated. The samples were homogenized and extracted with acetonitrile. After defatted with high speed frozen centrifugation, the supernatant solution was evaporated and the residue was dissolved with the mobile phase and defatted with n-hexane. It was then analyzed with UPLC-MS/MS. The limit of detection of this method was 0.1 microg/kg, and the limit of quantification was 0.5 microg/kg. The average recoveries (spiked at the levels of 0.5, 1.0, 2.0 microg/kg) ranged from 81.5% to 97.6%, with the relative standard deviations between 2.1% and 8.9%. The results demonstrated that the method is simple, accurate and suitable for the identification and quantification of these drug residues in chickens.
3.Use of gel permeation chromatography for clean-up in the analysis of coccidiostats in eggs by liquid chromatography-tandem mass spectrometry.
Chico J1, Rúbies A, Centrich F, Companyó R, Prat MD, Granados M. Anal Bioanal Chem. 2013 May;405(14):4777-86. doi: 10.1007/s00216-013-6896-z. Epub 2013 Mar 28.
An analytical method for determination and confirmation of nine coccidiostatics in eggs is reported. Ethyl acetate is used as extraction solvent, with satisfactory results, and simple automated clean-up is based on gel-permeation chromatography (GPC) . The target compounds are then analysed by liquid chromatography-electrospray ionization-tandem mass spectrometry. The method was validated in-house in accordance with Commission Decision 2002/657/EC. Trueness and precision were determined at four concentrations, and the mean errors obtained were <10 %, with relative standard deviations ranging from 3 to 18 %. For three non-authorized coccidiostatics (clopidol, ethopabate, and ronizadole), decision limit and detection capability were in the ranges 0.12-0.16 and 0.18-0.23 μg kg(-1), respectively. The results obtained prove the suitability of this new analytical method for routine monitoring of these substances in eggs.
4.Determination of 20 coccidiostats in milk, duck muscle and non-avian muscle tissue using UHPLC-MS/MS.
Clarke L1, Moloney M, O'Mahony J, O'Kennedy R, Danaher M. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2013;30(6):958-69. doi: 10.1080/19440049.2013.794306. Epub 2013 Jun 3.
In this paper, methods were developed to measure coccidiostats in bovine milk, duck muscle and non-avian species. The methods were validated to the maximum levels and MRLs laid down in European Union legislation. A simple sample preparation procedure was developed for the isolation of coccidiostat residues from bovine, ovine, equine, porcine and duck muscle tissue, based on solvent extraction with acetonitrile and concentration. An alternative method had to be developed for milk samples based on the QuEChERS sample preparation approach because of the high water content in this matrix. Milk samples were adjusted to basic pH with sodium hydroxide and extracted by using a slurry of acetonitrile, MgSO4 and NaCl. Purified sample extracts were subsequently analysed by using UHPLC-MS/MS in a 13.2-min chromatographic run. It was found that the use of rapid polarity switching enabled both negatively and positively charged ions to be analysed from a single injection.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Antiparasitic Products


CAS 26002-80-2 Phenothrin

Phenothrin
(CAS: 26002-80-2)

Phenothrin, also called as Forte or Sumithrin, a synthetic pyrethroid, is an antiparasitic drug that is used to kills adult fleas and ticks.

CAS 129496-10-2 Milbemycin Oxime

Milbemycin Oxime
(CAS: 129496-10-2)

Milbemycin oxime, a mixture of Milbemycin Oxime A3 and A4, is an antiparasitic and could be effectively used as an veterinary drug.

CAS 51-03-6 Piperonyl butoxide

Piperonyl butoxide
(CAS: 51-03-6)

Piperonyl butoxide works as an insecticide synergist. It is useful in inhibitng the insect microsomal enzyme detoxification activity and is always under the com...

CAS 133413-70-4 PF 1022A

PF 1022A
(CAS: 133413-70-4)

The cyclic depsipeptide PF1022A showed very good anthelmintic activity against Heligmosomoides polygyrus and Heterakis spumosa at 50 mg/kg. In vitro, PF1022A wa...

CAS 58-14-0 Pyrimethamine

Pyrimethamine
(CAS: 58-14-0)

Pyrimethamine is a medication used for protozoal infections. It could interfere with tetrahydrofolic acid synthesis from folic acid by inhibiting the enzyme dih...

CAS 117704-25-3 Doramectin

Doramectin
(CAS: 117704-25-3)

Doramectin is an antiparasitic agent.

CAS 7175-09-9 Tilbroquinol

Tilbroquinol
(CAS: 7175-09-9)

Tilbroquinol is an antiprotozoal agent effective against amoebiasis. It has been used against Vibrio cholerae.

CAS 3366-95-8 Secnidazole

Secnidazole
(CAS: 3366-95-8)

Secnidazole (Flagentyl) is a nitroimidazole anti-infective.

CAS 100-33-4 Pentamidine

Pentamidine
(CAS: 100-33-4)

Pentamidine is an antimicrobial agent.

CAS 97-18-7 Bithionol

Bithionol
(CAS: 97-18-7)

Bithionol is a clinically approved anti-parasitic drug. It has been shown to inhibit solid tumor growth in several preclinical cancer models. It caused dose dep...

CAS 123997-26-2 Eprinomectin

Eprinomectin
(CAS: 123997-26-2)

Eprinomectin(MK-397) is an avermectin selected for development as a topical endectocide; has anthelmintic, insecticidal and miticidal activity.

CAS 25514-31-2 Bruceine A

Bruceine A
(CAS: 25514-31-2)

Bruceine A inhibited the in vitro growth of Babesia gibsoni in canine erythrocytes at lower concentration compared with the standard antibabesial drug diminazen...

CAS 51773-92-3 Mefloquine Hydrochloride

Mefloquine Hydrochloride
(CAS: 51773-92-3)

Mefloquine HCl is a blood schizonticide by inhibiting hemozoin formation, used as an antimalarial drug.

CAS 3011-89-0 Aklomide

Aklomide
(CAS: 3011-89-0)

Aklomide is antiprotozoal agent against coccidiosis.

CAS 22662-39-1 Rafoxanide

Rafoxanide
(CAS: 22662-39-1)

Rafoxanide is a thyroid hormone receptor.

CAS 70288-86-7 Ivermectin

Ivermectin
(CAS: 70288-86-7)

Ivermectin is a broad-spectrum antiparasitic medication.

CAS 61438-64-0 Closantel Sodium

Closantel Sodium
(CAS: 61438-64-0)

Closantel is a salicylanilide anthelmintic compound; exhibits different anthelmintic spectra and apparent toxicity in mammals.

CAS 113507-06-5 Moxidectin

Moxidectin
(CAS: 113507-06-5)

Moxidectin is an anthelmintic drug which kills parasitic worms (helminths), and is used for the prevention and control of heartworm and intestinal worms.

CAS 43210-67-9 Fenbendazole

Fenbendazole
(CAS: 43210-67-9)

Fenbendazole is a broad spectrum benzimidazole anthelmintic used against gastrointestinal parasites with an IC50 of about 0.01 μg/ml

CAS 3818-50-6 Bephenium hydroxynaphthoate

Bephenium hydroxynaphthoate
(CAS: 3818-50-6)

Bephenium hydroxynaphthoate is an anthelmintic agent formerly used in the treatment of hookworm infections and ascariasis, which belongs to B-type AChR activato...

Chemical Structure

CAS 2971-90-6 Clopidol

Quick Inquiry

Verification code

Featured Items