Clofibric Acid - CAS 882-09-7
Catalog number: 882-09-7
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
Molecular Weight:
Clofibric acid is a PPAR agonist.
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1.Ultra-high-performance liquid chromatography-Time-of-flight high resolution mass spectrometry to quantify acidic drugs in wastewater.
Becerra-Herrera M1, Honda L2, Richter P3. J Chromatogr A. 2015 Dec 4;1423:96-103. doi: 10.1016/j.chroma.2015.10.071. Epub 2015 Oct 27.
A novel analytical approach involving an improved rotating-disk sorptive extraction (RDSE) procedure and ultra-high-performance liquid chromatography (UHPLC) coupled to an ultraspray electrospray ionization source (UESI) and time-of-flight mass spectrometry (TOF/MS), in trap mode, was developed to identify and quantify four non-steroidal anti-inflammatory drugs (NSAIDs) (naproxen, ibuprofen, ketoprofen and diclofenac) and two anti-cholesterol drugs (ACDs) (clofibric acid and gemfibrozil) that are widely used and typically found in water samples. The method reduced the amount of both sample and reagents used and also the time required for the whole analysis, resulting in a reliable and green analytical strategy. The analytical eco-scale was calculated, showing that this methodology is an excellent green analysis, increasing its ecological worth. The detection limits (LOD) and precision (%RSD) were lower than 90ng/L and 10%, respectively. Matrix effects and recoveries were studied using samples from the influent of a wastewater treatment plant (WWTP).
2.Batch vs continuous-feeding operational mode for the removal of pesticides from agricultural run-off by microalgae systems: A laboratory scale study.
Matamoros V1, Rodríguez Y2. J Hazard Mater. 2016 May 15;309:126-32. doi: 10.1016/j.jhazmat.2016.01.080. Epub 2016 Feb 1.
Microalgae-based water treatment technologies have been used in recent years to treat different water effluents, but their effectiveness for removing pesticides from agricultural run-off has not yet been addressed. This paper assesses the effect of microalgae in pesticide removal, as well as the influence of different operation strategies (continuous vs batch feeding). The following pesticides were studied: mecoprop, atrazine, simazine, diazinone, alachlor, chlorfenvinphos, lindane, malathion, pentachlorobenzene, chlorpyrifos, endosulfan and clofibric acid (tracer). 2L batch reactors and 5L continuous reactors were spiked to 10μgL(-1) of each pesticide. Additionally, three different hydraulic retention times (HRTs) were assessed (2, 4 and 8 days) in the continuous feeding reactors. The batch-feeding experiments demonstrated that the presence of microalgae increased the efficiency of lindane, alachlor and chlorpyrifos by 50%. The continuous feeding reactors had higher removal efficiencies than the batch reactors for pentachlorobenzene, chlorpyrifos and lindane.
3.Perchlorate formation during the electro-peroxone treatment of chloride-containing water: Effects of operational parameters and control strategies.
Lin Z1, Yao W1, Wang Y2, Yu G1, Deng S1, Huang J1, Wang B1. Water Res. 2016 Jan 1;88:691-702. doi: 10.1016/j.watres.2015.11.005. Epub 2015 Nov 5.
This study investigated the degradation of clofibric acid and formation of perchlorate during the electro-peroxone (E-peroxone) treatment of chloride-containing (26.1-100 mg L(-1)) water (Na2SO4 electrolytes and secondary effluents). The E-peroxone process involves sparging O2 and O3 gas mixture into an electrolysis reactor where a carbon-based cathode is used to electrochemically convert the sparged O2 to H2O2. The electro-generated H2O2 then reacts with sparged O3 to produce OH, which can rapidly oxidize pollutants in the bulk solution. When boron-doped diamond (BDD) electrodes were used as the anode, perchlorate concentrations increased significantly from undetectable levels to ∼15-174 mg L(-1) in the different water samples as the applied current density was increased from 4 to 32 mA cm(-2). In contrast, no ClO4(-) was detected when Pt/Ti anodes were used in the E-peroxone process operated under similar reaction conditions. In addition, when sufficient O3 was sparged to maximize OH production from its peroxone reaction with electro-generated H2O2, the E-peroxone process with Pt/Ti anodes achieved comparable clofibric acid degradation and total organic carbon (TOC) removal yields as that with BDD anodes, but did not generate detectable ClO4(-).
4.Use of hydrodynamic cavitation in (waste)water treatment.
Dular M1, Griessler-Bulc T2, Gutierrez-Aguirre I3, Heath E4, Kosjek T4, Krivograd Klemenčič A2, Oder M5, Petkovšek M6, Rački N3, Ravnikar M3, Šarc A6, Širok B6, Zupanc M4, Žitnik M5, Kompare B7. Ultrason Sonochem. 2016 Mar;29:577-88. doi: 10.1016/j.ultsonch.2015.10.010. Epub 2015 Oct 19.
The use of acoustic cavitation for water and wastewater treatment (cleaning) is a well known procedure. Yet, the use of hydrodynamic cavitation as a sole technique or in combination with other techniques such as ultrasound has only recently been suggested and employed. In the first part of this paper a general overview of techniques that employ hydrodynamic cavitation for cleaning of water and wastewater is presented. In the second part of the paper the focus is on our own most recent work using hydrodynamic cavitation for removal of pharmaceuticals (clofibric acid, ibuprofen, ketoprofen, naproxen, diclofenac, carbamazepine), toxic cyanobacteria (Microcystis aeruginosa), green microalgae (Chlorella vulgaris), bacteria (Legionella pneumophila) and viruses (Rotavirus) from water and wastewater. As will be shown, hydrodynamic cavitation, like acoustic, can manifest itself in many different forms each having its own distinctive properties and mechanisms.
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CAS 882-09-7 Clofibric Acid

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