Clodronate disodium - CAS 10596-23-3
Catalog number:
10596-23-3
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
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Description:
clodronate disodium is the disodium salt of a nitrogen-free bisphosphonate analog of naturally occurring pyrophosphate. Clodronate binds to calcium and inhibits osteoclastic bone resorption and hydroxyapatite crystal formation and dissolution, resulting in a reduction of bone turnover. This agent may control malignancy-associated hypercalcemia, inhibit osteolytic bone metastasis and decrease pain. Check for active clinical trials or closed clinical trials using this agent.
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Purity:
>98%
Appearance:
white solid powder
Synonyms:
clodronic acid disodium salt; disodium dichloromethylene diphosphonate; Dichloromethylenediphosphonic acid disodium salt. Bonefos; Clasteon; Difosfonal; Loron; Mebonat; Ossiten. CL2MDP; DMDP.
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1.CLODRONATE: OLD DRUG, NEW USES.
Saviola G1, Abdi-Ali L1, Povino MR1. J Biol Regul Homeost Agents. 2015 Jul-Sep;29(3):719-22.
Clodronate (CLO) is a bisphosphonate (BP) with proved efficacy in the treatment of osteoporosis. The reason of its activity is the anti-resorptive action, which is a common characteristic of BPs. Contrary to other BPs, CLO has a relatively low affinity for bone and a peculiar mechanism of action. CLO is effective in several diseases associated to excessive bone resorption as bone Paget’s disease and CRPS type I. Moreover, there are data showing activity of CLO in the erosive osteoarthritis of the hands, in the osteoarthritis of the knees, in the treatment of extra-articular calcifications and in preventing the mobilization of knee and hip prosthesis.
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CAS 10596-23-3 Clodronate disodium

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