Clidinium Bromide - CAS 3485-62-9
Catalog number: 3485-62-9
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
C22H26BrNO3
Molecular Weight:
432.35
COA:
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Targets:
mAChR
Description:
Clidinium bromide is an anticholinergic used as an antispasmodic to reduce stomach acid and decreases intestinal spasms.
Purity:
95%
Appearance:
White Solid
Synonyms:
(1-methyl-1-azoniabicyclo[2.2.2]octan-3-yl) 2-hydroxy-2,2-diphenylacetate;bromide;
Solubility:
Soluble in DMSO
Storage:
Store at -20 °C
MSDS:
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Application:
An anticholinergic. Used as an antispasmodic.
Quality Standard:
Enterprise Standard
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Quantity:
Grams-Kilos
Melting Point:
240-241ºC
Density:
g/cm3
InChIKey:
GKEGFOKQMZHVOW-UHFFFAOYSA-M
InChI:
InChI=1S/C22H26NO3.BrH/c1-23-14-12-17(13-15-23)20(16-23)26-21(24)22(25,18-8-4-2-5-9-18)19-10-6-3-7-11-19;/h2-11,17,20,25H,12-16H2,1H3;1H/q+1;/p-1
Canonical SMILES:
C[N+]12CCC(CC1)C(C2)OC(=O)C(C3=CC=CC=C3)(C4=CC=CC=C4)O.[Br-]
Current Developer:
Roche
1.Evaluation of the benefit of addition of clidinium C to a Helicobacter pylori eradication regimen.
Chorami M1, Zojaji H1, Naderi N1, Moghimi-Dehkordi B2, Mirsattari D1, Shalmani HM1. Gastroenterol Hepatol Bed Bench. 2013 Summer;6(3):141-5.
AIM: This study aimed to evaluate the success of H.pylori eradication therapy in patients with dyspepsia by therapeutics regimes with and without clidinium C.
2.Stability-indicating HPLC method for simultaneous determination of clidinium bromide and chlordiazepoxide in combined dosage forms.
Pathak A1, Rai P, Rajput SJ. J Chromatogr Sci. 2010 Mar;48(3):235-9.
The study describes development and subsequent validation of a stability indicating reverse-phase high-performance liquid chromatography method for the simultaneous estimation of clidinium bromide (CLI) and chlordiazepoxide (CHLOR) from their combination drug product. Chromatographic separations are performed at ambient temperature on a Phenomenex Luna C(18) (250 mm x 4.6 mm, i.d., 5 microm) column using a mobile phase consisting of potassium dihydrogen phosphate buffer (0.05 M, pH 4.0 adjusted with 0.5% orthophosphoric acid)-methanol- acetonitrile (40:40:20, v/v/v). The flow rate is 1.0 mL/min, and the detection wavelength is 220 nm. The method is validated with respect to linearity, precision, accuracy, system suitability, and robustness. The utility of the procedure is verified by its application to marketed formulations that were subjected to accelerated degradation studies. The method distinctly separated the drug and degradation products even in actual samples.
3.Simultaneous Determination of Clidinium Bromide and Chlordiazepoxide in Combined Dosage Forms by High-Performance Liquid Chromatography.
Ashour S1, Kattan N1. J Pharm (Cairo). 2013;2013:417682. doi: 10.1155/2013/417682. Epub 2013 Feb 24.
A sensitive and precise RP-HPLC method has been developed for the simultaneous estimation of clidinium bromide (CDB) and chlordiazepoxide (CDZ) in pure and pharmaceutical formulations. The separation was achieved on a Nucleodur C8 (250 × 4.6 mm i.d., 5 μm particle size) column at 25°C. CH3CN-MeOH-NH4OAc 0.1M (30 : 40 : 30, v/v/v) was used as the mobile phase at a flow rate of 1.0 mL min(-1) and detector wavelength at 218 nm. Almotriptan (ALT) was used as internal standard. The validation of the proposed method was carried out for linearity, accuracy, precision, LOD, LOQ, and robustness. The method showed good linearity in the ranges of 2.5-300.0 and 3.0-500.0 μg mL(-1) for CDB and CDZ, respectively. The percentage recovery obtained for CDB and CDZ was 100.40-103.38 and 99.98-105.59%, respectively. LOD and LOQ were 0.088 and 0.294 μg mL(-1) for CDB and 0.121 and 0.403 μg mL(-1) for CDZ, respectively. The proposed method was successfully applied to the determination of CDB and CDZ in combined dosage forms and the results tallied well with the label claim.
4.Imaging left ventricular muscarinic receptor heterogeneity: a tool to evaluate individuals at risk for sudden death?
Caldwell JH, Link JM. Circ Cardiovasc Imaging. 2009 Sep;2(5):353-5. doi: 10.1161/CIRCIMAGING.109.900621.
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CAS 3485-62-9 Clidinium Bromide

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