CL-387785 - CAS 194423-06-8
Catalog number:
194423-06-8
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
COA:
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Targets:
EGFR
Description:
CL-387785, also known as EKI-785, is an irreversible inhibitor of EGF-receptor (EGFR) kinase activity in vivo (IC50 = 250-490 pM). CL-387785 covalently bound to EGF-R. It also specifically inhibited kinase activity of the protein (IC50 = 370+/-120 pM), blocked EGF-stimulated autophosphorylation of the receptor in cells (ic50 approximately 5 nM), inhibited cell proliferation (IC50 = 31-125 nM) primarily in a cytostatic manner in cell lines that overexpress EGF-R or c-erbB-2, and profoundly blocked the growth of a tumor that overexpresses EGF-R in nude mice (when given orally at 80 mg/kg/day for 10 days, daily). CL-387,785 is useful for studying the interaction of small molecules with EGF-R and may have clinical utility.
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Purity:
0.98
Appearance:
Solid powder
Synonyms:
CL-387785; CL 387785; CL-387,785; CL387785; EKI-785
MSDS:
Inquire
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

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CAS 194423-06-8 CL-387785

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