CJ-42794 - CAS 847728-01-2
Catalog number:
847728-01-2
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C22H17ClFNO4
Molecular Weight:
413.83
COA:
Inquire
Targets:
Prostaglandin Receptor
Description:
CJ-42794 is a selective prostaglandin E receptor subtype 4 (EP4) antagonist. It inhibits [3H]-PGE2 binding to the human EP4 receptor with a mean pKi of 8.5. It competitively antagonized cAMP accumulation with a pA2 value of 8.7 in HEK293 cells overexpressing rat prostanoid EP4 receptors. It did not exhibit any remarkable binding to 65 additional proteins, including GPCRs, enzymes, and ion channels. It reversed the inhibitory effects of PGE2 on LPS-induced TNFα production in a concentration-dependent manner. It has excellent pharmacological properties that make it a useful tool for exploring the physiological role of EP4 receptors .
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Purity:
>98%
Appearance:
Solid powder
Synonyms:
4-[(1S)-1-[[5-chloro-2-(4-fluorophenoxy)benzoyl]amino]ethyl]benzoic acid;(S)-4-(1-(5-chloro-2-(4-fluorophenoxy)benzaMido)ethyl)benzoic acid;CJ-042794;4-((S)-1-(2-(4-fluorophenoxy)-5-chlorobenzamido)ethyl)benzoic acid;
Solubility:
10 mM in DMSO
Storage:
-20°C Freezer
MSDS:
Inquire
Application:
CJ-42794 has excellent pharmacological properties that make it a useful tool for exploring the physiological role of EP4 receptors .
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Quantity:
Grams-Kilos
Boiling Point:
572.7±50.0 °C | Condition: Press: 760 Torr
Density:
1.347±0.06 g/cm3 | Condition: Temp: 20 °C Press: 760 Torr
InChIKey:
MWBNCZHVEXULBD-ZDUSSCGKSA-N
InChI:
InChI=1S/C22H17ClFNO4/c1-13(14-2-4-15(5-3-14)22(27)28)25-21(26)19-12-16(23)6-11-20(19)29-18-9-7-17(24)8-10-18/h2-13H,1H3,(H,25,26)(H,27,28)/t13-/m0/s1
Canonical SMILES:
CC(C1=CC=C(C=C1)C(=O)O)NC(=O)C2=C(C=CC(=C2)Cl)OC3=CC=C(C=C3)F
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

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CAS 847728-01-2 CJ-42794

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