1.Phenolic composition and antiparasitic activity of plants from the Brazilian Northeast "Cerrado".
Calixto Júnior JT1, de Morais SM1, Gomez CV2, Molas CC2, Rolon M2, Boligon AA3, Athayde ML3, de Morais Oliveira CD4, Tintino SR4, Henrique Douglas MC4. Saudi J Biol Sci. 2016 May;23(3):434-40. doi: 10.1016/j.sjbs.2015.10.009. Epub 2015 Oct 23.
This work describes the antiparasitic and cytotoxic activities of three plant species from the Cerrado biome, Northeastern Brazil. Significant antiparasitic inhibition was observed against Trypanosoma cruzi (63.86%), Leishmania brasiliensis (92.20%) and Leishmania infantum (95.23%) when using ethanol extract from leaves of Guazuma ulmifolia Lam. (Malvaceae), at a concentration of 500 μg/mL. However, low levels of inhibition were observed when assessing leishmanicidal and trypanocidal (Clone CL-B5) activities of crude ethanol extracts from leaves and bast tissue of Luehea paniculata (Malvaceae) and leaves and bark of Prockia crucis (Salicaceae) at a concentration of 500 μg/mL. The extracts revealed the presence of phenolic acids such as gallic acid, chlorogenic acid, caffeic acid and rosmarinic acid, as well as flavonoids such as rutin, luteolin, apigenin and quercetin - the latter detected only in G. ulmifolia. G. ulmifolia extract displayed higher leishmanicidal activity probably due to the presence of quercetin, a potent known leishmanicidal compound.
2.Ethanol extract of Kalopanax septemlobus leaf inhibits HepG2 human hepatocellular carcinoma cell proliferation via inducing cell cycle arrest at G1 phase.
Park C1, Jeong JS2, Jeong JW3, Kim SO4, Kim YJ5, Kim GY6, Hong SH7, Choi YH8. Asian Pac J Trop Med. 2016 Apr;9(4):344-350. doi: 10.1016/j.apjtm.2016.03.003. Epub 2016 Mar 8.
OBJECTIVE: To investigate the effects of an ethanol extract of Kalopanax septemlobus (Thunb.) Koidz. leaf (EEKS) on cell proliferation in human hepatocellular carcinoma cells and its mechanisms of action.
3.Effect of Beverage Containing Fermented Akebia quinata Extracts on Alcoholic Hangover.
Jung S1, Lee SH2, Song YS2, Lee SY2, Kim SY2, Ko KS2. Prev Nutr Food Sci. 2016 Mar;21(1):9-13. doi: 10.3746/pnf.2016.21.1.9. Epub 2016 Mar 31.
The present study was conducted to investigate the effects of beverages containing fermented Akebia quinata extracts on alcoholic hangover. For this study, 25 healthy young men were recruited. All participants consumed 100 mL of water (placebo), commercial hangover beverage A or B, fermented A. quinata leaf (AQL) or fruit (AQF) extract before alcohol consumption. After 1 h, all participants consumed a bottle of Soju, Korean distilled liquor (360 mL), containing 20% alcohol. Blood was collected at 0 h, 1 h, 3 h, and 5 h after alcohol consumption. The plasma alanine transaminase (ALT) activity was highest in the placebo group. Compared with the control group, the AQL and AQF groups showed decreased ALT activity at 5 h after alcohol consumption. Plasma ethanol concentration was increased after alcohol intake and peaked at 3 h after alcohol consumption. Compared with the control group, the A group showed a higher plasma ethanol concentration at 1 h (P<0.
4.Antibacterial Constituents of Hainan Morinda citrifolia (Noni) Leaves.
Zhang WM1, Wang W1, Zhang JJ2, Wang ZR2, Wang Y2, Hao WJ2, Huang WY3. J Food Sci. 2016 Apr 13. doi: 10.1111/1750-3841.13302. [Epub ahead of print]
Noni (Morinda citrifolia L.) is an edible and medicinal plant distributed in Hainan, China. The antibacterial activities of the extracts of water (WE), petroleum ether (PEE), ethyl acetate (EAE), chloroform (CE), and n-butanol (BE) were assayed by the disk diffusion method. The results showed that the extracts from Noni leaves possessed antibacterial effects against Bacillus subtilis, Escherichia coli, Proteus vulgaris, and Staphylococcus aureus. Among 5 different extracts, the BE produced the best antibacterial activity. The samples were first extracted by ethanol, and the primary compounds in the BE fraction of ethanol extract was further isolated and identified. Six phenolic compounds, including 5, 15-dimethylmorindol, ferulic acid, p-hydroxycinamic acid, methyl 4-hydroxybenzoate, methyl ferulate, and methyl 4-hydroxycinnamate, were identifiedby NMR. The results indicated that the phenolic compounds might significantly contribute to antibacterial activities of Noni leaves.