|Description||Cinepazide is a vasodilator. Cinepazide (30 mg/kg, i.v.) potentiated the vertebral vasodilator response of dogs to intravertebral adenosine and cyclic AMP, Intravertebral cinepazide(1-10 mg) increased vertebral blood flow in a dose-related manner and the effect was partially inhibited by intravenous pretreatment with aminophylline but not by pretreatment with autonomic antagonists. Cinepazide resembled cinnarizine and papaverine in that the drug antagonized rabbit aortic contraction induced by KCl, norepinephrine or CaCl2. Cinepazide in concentrations ranging from 10-6 to 10-5M augmented the relaxing responses to ATP, adenosine and cAMP. However, this agent did not affect the relaxations induced by isoproterenol and papaverine and the contractions induced by 5-HT, prostaglandin F2α and ATP. cinepazide selectively potentiates the relaxing response mediated through purinergic P1 receptors.|
Tomicorat is used as an anti-inflammatory agent.
Bismuth Subsalicylate is the active ingredient in Pepto-Bismol and inhibits prostaglandin G/H Synthase 1/2.
GAT-100, an indole derivative, has been found to be a negative allosteric modulator that could be used as a covalent probe in studying of the binding motifs of ...
CB 3731 can be used in fluorine-19 nuclear magnetic resonance studies of binary and ternary complexes of thymidylate synthase.
Glafenine hydrochloride, an anthranilic acid derivative, is a non-narcotic analgesic and non-steroidal anti-inflammatory drug. It is an ABCG2 inhibitor (IC50= 3...
Olesoxime (TRO19622) is an experimental neuroprotective drug. It is the lead compound of Trophos' cholesterol-oxime compound family of mitochondrial pore modula...
Etimizol was shown to relieve amnesia effectively in the origin of which there is the hypoxic component (hypobaric hypoxia, actinomycin D, mechanical injury of ...
AP1903 is a lipid-permeable tacrolimus analogue with homodimerizing activity. Dimerizer drug AP1903 homodimerizes an analogue of human protein FKBP12 (Fv) which...
4-Aminohippuric acid is a typical substrate of organic anion transport systems.
Elsibucol, a metabolically stable derivative of probucol, inhibits atherosclerosis and preserves endothelial healing following arterial injury. In vitro, elsibu...
Gastrin-Releasing Peptide, human
Gastrin-Releasing Peptide, human (GRP), one of the bombesin-like peptide family, is an agonist for the gastrin-releasing peptide receptor (GRPR) and it plays on...
Nitazoxanide is a synthetic nitrothiazolyl-salicylamide derivative and an antiprotozoal agent. (IC50 for canine influenza virus ranges from 0.17 to 0.21 μM)
Gaxilose is a synthetic disaccharide and a substrate of intestinal lactase. It can be applicated in a new noninvasive diagnostic test based on urine or serum me...
Dihydrosanguinarine (DHSG) is a metabolite of Sanguinarine with antifungal activity.
ND-630, also called as NDI 010976, is a highly selective, reversible inhibitor of acetyl-CoA carboxylase (ACC) and had IC50 values of 2 and 7 nM for ACC1 and 2,...
Allylthiourea is a metabolic inhibitor that selective inhibits ammonia oxidation.
CH 141 is a peripheral vasodilator.
NDGA (Nordihydroguaiaretic acid), also known as masoprocol, is a naturally occurring antioxidant dicatechol originally derived from the creosote bush Larrea di...
Melatonin is a hormone produced in the brain by the pineal gland from the amino acid tryptophan. It can be used as a antioxidant therapy. Melatonin is involved ...
Bay 02752 is a bio-active molecular, but no detailed information has been published yet.