|Description||Cinepazide is a vasodilator. Cinepazide (30 mg/kg, i.v.) potentiated the vertebral vasodilator response of dogs to intravertebral adenosine and cyclic AMP, Intravertebral cinepazide(1-10 mg) increased vertebral blood flow in a dose-related manner and the effect was partially inhibited by intravenous pretreatment with aminophylline but not by pretreatment with autonomic antagonists. Cinepazide resembled cinnarizine and papaverine in that the drug antagonized rabbit aortic contraction induced by KCl, norepinephrine or CaCl2. Cinepazide in concentrations ranging from 10-6 to 10-5M augmented the relaxing responses to ATP, adenosine and cAMP. However, this agent did not affect the relaxations induced by isoproterenol and papaverine and the contractions induced by 5-HT, prostaglandin F2α and ATP. cinepazide selectively potentiates the relaxing response mediated through purinergic P1 receptors.|
Chitinase-IN-2 is a insect chitinase and N- acetyl hexosaminidase inhibitor and pesticide; 50 uM/20uM compound concentration's inhibitory percentage are 98%...
Proctolin, an endogenous pentapeptide, was the first myotropic insect neuromodulator to be structurally characterized.
Rocuronium is an aminosteroid non-depolarizing neuromuscular blocker or muscle relaxant used in modern anaesthesia.
Sulfacetamide is a sulfonamide antibiotic as a dihydropteroate Synthase inhibitor. It is a competitive inhibitor of bacterial para-aminobenzoic acid, which is r...
Novaluron is a chemical with pesticide properties, belonging to the class of insecticides called insect growth regulators. It inhibits chitin formation, targeti...
Tretinoin, which is a ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR), can induce granulocytic differentiation and apoptosis ...
XEN445 is a potent and selective endothelial lipase inhibitor with IC50 of 0.237 μM.
CDK2, a member of the eukaryotic S/T protein kinase family, catalyzes the phosphoryl transfer of ATP γ-phosphate to serine or threonine hydroxyl (denoted as S0/...
LM985, the diethylaminoester derivative of LM975, has anti-tumor activities.
Dioxybenzone, a phenol derivative, could be widely used to block UVB and UVA in sunscreen products.
Tetracaine is a topical local anesthetic for the eyes. It works by interfering with entry of sodium ions into nerve cells. It is also used in assessing the pote...
Epelsiban is an oxytocin receptor antagonist under the developement of GlaxoSmithKline. It has high affinity for the oxytocin receptor (Ki = 0.13 nM) with >31,0...
Exherin, also known as ADH-1, is a small, cyclic pentapeptide vascular-targeting agent with potential antineoplastic and antiangiogenic activities. ADH-1 select...
VRX-806 is a novel nonnucleoside reverse transcriptase inhibitor (NNRTI) with potent in vitro activity against wild-type and NNRTI-resistant HIV-1.
APC-366, an amino acid derivative, has been found to be a mast cell tryptase inhibitor and was once studied against asthma by Celera Genomics Group. Ki: 7.1 μM.
Imazapic, a 2-substituted imidazole derivative, is a selective herbicide which could be commonly used for the preand post-emergent control of some sorts of annu...
CP-67804 enhances topoisomerase II-mediated DNA cleavage. It represent a novel class of topoisomerase II-targeted drugs which have potential as antineoplastic a...
BMS 433771 is a potent inhibitor of RSV replication in vitro with an average EC of 20nM
Wogonin is a cell-permeable and orally available flavonoid that displays anti-inflammatory and anticancer properties.
The hydrochloride salt form of Emixustat which could effectively inhibit the production of 11-cis-retinol which is related to age-related macular degeneration.