Cinepazide - CAS 23887-46-9
Catalog number: 23887-46-9
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
Molecular Weight:
Cinepazide is a vasodilator. Cinepazide (30 mg/kg, i.v.) potentiated the vertebral vasodilator response of dogs to intravertebral adenosine and cyclic AMP, Intravertebral cinepazide(1-10 mg) increased vertebral blood flow in a dose-related manner and the effect was partially inhibited by intravenous pretreatment with aminophylline but not by pretreatment with autonomic antagonists. Cinepazide resembled cinnarizine and papaverine in that the drug antagonized rabbit aortic contraction induced by KCl, norepinephrine or CaCl2. Cinepazide in concentrations ranging from 10-6 to 10-5M augmented the relaxing responses to ATP, adenosine and cAMP. However, this agent did not affect the relaxations induced by isoproterenol and papaverine and the contractions induced by 5-HT, prostaglandin F2α and ATP. cinepazide selectively potentiates the relaxing response mediated through purinergic P1 receptors.
Publictions citing BOC Sciences Products
  • >> More
1.Cinepazide maleate protects PC12 cells against oxygen-glucose deprivation-induced injury.
Zhao J1, Bai Y, Zhang C, Zhang X, Zhang YX, Chen J, Xiong L, Shi M, Zhao G. Neurol Sci. 2014 Jun;35(6):875-81. doi: 10.1007/s10072-013-1618-z. Epub 2013 Dec 29.
Our previous study showed that cinepazide maleate (CM) was as effective and safe as mildronate in the treatment of acute ischemic stroke in a randomized, double-blind, active-controlled phase II multicenter trial, but underlying mechanism(s) is not well understood. As an extending study, here we demonstrated that CM could protect neuronal cells by affecting mitochondrial functions. PC12 cells were exposed to 2.5 h oxygen-glucose deprivation (OGD) followed by a 24 h reoxygenation, and then treated with different concentrations (1, 10, 100 μM) of CM. Among various concentrations, 10 μM CM exhibited most significant protection on PC12 cells against OGD injury. CM was found to suppress OGD-induced oxidative stress, as supported by its capability of reducing intracellular reactive oxygen species and malondialdehyde production and enhancing superoxide dismutase activity. Importantly, our results showed that CM could preserve mitochondrial functions, as revealed by its capability of stabilizing mitochondrial membrane potential, improving OGD-induced suppression of mitochondrial respiratory complex activities and enhancing ATP production.
2.High performance liquid chromatographic method for the determination of cinepazide maleate and its application to a pharmacokinetic study in rats.
Zhao J1, Song Y1, Wang H2, Sun Y1, Liu M1, Lu C1, Li Y1, Wang S1, Zhu X1, Hai W1, Wen A3, Jia Y4. J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Apr 15;957:105-9. doi: 10.1016/j.jchromb.2014.02.038. Epub 2014 Mar 4.
A simple and reliable high performance liquid chromatographic (HPLC) method has been developed and validated to quantify cinepazide maleate, a calcium blocker, in rat plasma. Cinepazide maleate and Tinidazole (internal standard) have been extracted by a simple liquid-liquid extraction before injection into chromatographic system. Chromatographic separation was achieved on a reversed phase C18 column with a mobile phase consisted of a water mixture of 10mM potassium dihydrogen phosphate (pH=4.5):methanol (40:60, v/v), pumped at flow rate of 1.0mL/min, and detected at 303nm. The method exhibited a linear range of 0.12-120μg/mL in blank rat plasma, with the lower detection limit of 0.06μg/mL. The method was statistically validated for linearity, accuracy, precision, selectivity and stability following FDA guidelines. The intra- and inter-assay coefficients of variation did not exceed ±15% from the nominal concentration. The accuracy of cinepazide maleate was within ±15% of the theoretical value.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Products

(CAS: 1610676-27-1)

CFI-401980, a pyrazolotriazin derivative, has been found to be a TTK inhibitor that could exhibit good antiproliferative activity in some human cancer cell line...

CAS 50-03-3 Hydrocortisone acetate

Hydrocortisone acetate
(CAS: 50-03-3)

Hydrocortisone acetate, a derivative of hydrocortisone, is a corticosteroid compound that has a broad range of anti-inflammatory and immunosuppressive effects a...

CAS 196391-82-9 Prosaptide TX14(A)

Prosaptide TX14(A)
(CAS: 196391-82-9)

Prosaptide TX14(A) is a potent agonist of G protein-coupled receptors GPR37 and GPR37L1 (EC50 values are 7 and 5 nM, respectively). Prosaptide Tx 14(A) is the a...

CAS 40957-83-3 Glycitein

(CAS: 40957-83-3)

Glycitein is a soybean (yellow cultivar) isoflavonoid. It may be used to study anti-oxidation processes at the level of gene transcription where it increases th...

(CAS: 333389-24-5)

BMS-419437 is a synthetic organic bio-active chemical.

CAS 102396-24-7 Jasplakinolide

(CAS: 102396-24-7)

Jasplakinolide acts as an actin stabilizing agent that stabilizes actin filaments and promotes actin polymerization. It is also a potent inhibitor of breast and...

(CAS: 159857-80-4)

MC-Val-Cit-PAB-OH, a kind of ADC peptide linker, could be used in the formation of ADC conjugate and be significant in anticancer studies.

CAS 109229-57-4 Englitazone sodium

Englitazone sodium
(CAS: 109229-57-4)

Englitazone sodium is a novel blocker of NSCa and KATP channels. It is an antidiabetic agent.

CAS 118506-26-6 Myelin Basic Protein (87-99)

Myelin Basic Protein (87-99)
(CAS: 118506-26-6)

Myelin Basic Protein (87-99) is a encephalitogenic peptide that induces T cell proliferation with Th1 polarization in the CNS. Myelin basic protein (MBP) is a p...

CAS 53963-43-2 Ginsenoside F1

Ginsenoside F1
(CAS: 53963-43-2)

Ginsenoside F1, a metabolite of ginsenoside Rg1, which is used as an aldose reductase inhibitor and my exert anti-inflammatory and immunomodulatory activity.

CAS 353519-63-8 HLM006474

(CAS: 353519-63-8)

HLM 006474 acts as an E2F transcription factor inhibitor, preventing DNA binding activity. This results in the induction of apoptosis in breast cancer cells.

CAS 6310-41-4 NSC-41589

(CAS: 6310-41-4)

N-[2-(methylsulfanyl) phenyl]acetamide

(CAS: 410074-73-6)

Amitifadine is an antidepressant drug candidate which reduces the duration of immobility in the forced swim test in rats with an oral minimum effective dose (ME...

CAS 6859-01-4 Isorhynchophylline

(CAS: 6859-01-4)

Rhynchophylline and isorhynchophylline act as noncompetitive antagonists of the NMDA receptor and that this property may contribute to the neuroprotective and a...

CAS 342779-66-2 NCRW0005-F05

(CAS: 342779-66-2)

NCRW0005-F05 is the first GPR139 antagonist (IC50 = 0.21 µM).

CAS 905-99-7 Cryptochlorogenic acid

Cryptochlorogenic acid
(CAS: 905-99-7)

Cryptochlorogenic acid is an isomer of chlorogenic acid. It is a natural product extracted from the flowerbud of Lonicera japonica Thunb. It has antioxidant act...

CAS 382-45-6 Adrenosterone

(CAS: 382-45-6)

Adrenosterone is a steroid hormone with weak androgenic effect. It is thought to be a competitive selective 11βHSD1inhibitor, which is responsible for activatio...

Epothilone F
(CAS: 208518-52-9)

Epothilone F, an active metabolite of Epothilone D, prevents cancer cells from dividing by interfering with tubulin.

CAS 1414963-82-8 NK 252

NK 252
(CAS: 1414963-82-8)

NK 252 is a Nrf2 activator. It can induce expression of an antioxidant response element promoter driven reporter gene.

(CAS: 101184-07-0)

CK-2130 is a bio-active imidazolone developed to treat congestive heart failure. It inhibited human platelet aggregation produced by adenosine diphosphate and s...

Chemical Structure

CAS 23887-46-9 Cinepazide

Quick Inquiry

Verification code

Featured Items