Cinchophen - CAS 132-60-5
Catalog number: 132-60-5
Category: Inhibitor
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Molecular Formula:
C16H11NO2
Molecular Weight:
249.26
COA:
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Targets:
Others
Description:
Cinchophen is an analgesic drug that is frequently used to treat gout.
Purity:
>98%
Synonyms:
Cinchopen; Mylofanol; Agotan; Phenophan; Tervalon; NSC2617; NSC-2617; NSC 2617
MSDS:
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InChIKey:
YTRMTPPVNRALON-UHFFFAOYSA-N
InChI:
InChI=1S/C16H11NO2/c18-16(19)13-10-15(11-6-2-1-3-7-11)17-14-9-5-4-8-12(13)14/h1-10H,(H,18,19)
Canonical SMILES:
C1=CC=C(C=C1)C2=NC3=CC=CC=C3C(=C2)C(=O)O
1. Effects of activated granulocytes and O2-on microcirculatory injury in acute gastric mucosal lesion in rats induced by sodium cinchophen
TSUSHI TAKAHASHI, YUKIO NAGAMACHI and NORIAKI HATTORI. J Gastroenterol 1996; 31:153-160
The rats were divided into two groups, cinchophen-injected (cinchophen ulcer, CU) and ischemia-reperfused (IR): In the CU group, 300mg/kg of sodium cinchophen was injected intravenously for 5 min; in the IR group, the left gastric artery and vein were clamped to the esophagus with Pean's forceps for pediatric surgery for 30 min. Mucosal levels of IL-8 were measured in both groups. Leukopenia was induced in some rats in each group, and the amount of extravasated Evans blue, changes in blood flow, and the formation of vascular casts in the gastric mucosa were studied in CU and IR rats with and without leukopenia. The effect of SOD on MCI was also studied in the CU and IR groups without leukopenia by observing the formation of vascular casts.
2. SIGNIFICANCE OF GASTRIC MUCOSAL PEPSINOGEN AND PLASMA CORTICOSTEROID LEVELS IN THE COURSE OF CINCHOPHEN ULCERATION
Yukio NAGAMACHI, M.D. Gastroenterologia Japonica, Vol. 12, No. 1
In the dog, the systemic administration of cinchophen for about 3 weeks results in chronic peptic ulcers with the characteristics of human ulcers. In most dogs given repeated administration of cinchophen, bleedings and superficial mucosal lesions were visible in the fundic gland area within 7 days agreeing with reports by previous workers. During the period of cinchophen administration, there was a shift in the level of the plasma ll- hydroxycorticoids . These effects are not observed when the pituitary stalk is sectioned or the median eminence of the hypothalamus is lesioned. It can be suggested therefore that the hypothalamus may play a major part in cinchophen ulcer formation by means of hypothalamo-pituitary-adrenal mechanism. It has been postulated that stress ulceration is a manifestation of increased adrenocortical function).
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CAS 132-60-5 Cinchophen

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