|Description||CID-755673 is a selective protein kinase D (PKD) inhibitor. CID-755673 was identified from the National Institutes of Health small molecule repository library of 196,173 compounds. In cell-based assays, CID755673 blocked phorbol ester-induced endogenous PKD1 activation in LNCaP cells in a concentration-dependent manner. CID755673 inhibited prostate cancer cell proliferation, cell migration, and invasion. In summary, our findings indicate that CID755673 is a potent and selective PKD1 inhibitor with valuable pharmacological and cell biological potential.|
|Appearance||brown solid powder|
|Synonyms||CID-755673; CID 755673; CID755673|
kb NB 142-70
kb-NB142-70 is a derivative of the PKD1 inhibitor CID755673, with approximately 6-fold greater potency (IC50 for inhibition of PKD1 = 28.3 nM vs. 182 nM for CID...
CRT0066101 is a small-molecule protein kinase D (PKD) inhibitor that suppresses PDK1, PDK2 and PDK3 (PDK1: IC50 = 1 nM; PDK2: IC50 = 2.5 nM; PDK3: IC50 = 2 nM)....
CID-755673 is a selective protein kinase D (PKD) inhibitor. CID-755673 was identified from the National Institutes of Health small molecule repository library o...