Ciclopirox ethanolamine - CAS 41621-49-2
Catalog number: B0084-068466
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
Molecular Weight:
Ciclopirox ethanolamine (Ciclopirox olamine, HOE 296) is a broad-spectrum antifungal agent working as an iron chelator.
Ordering Information
Catalog Number Size Price Stock Quantity
B0084-068466 25 g $169 In stock
Bulk Inquiry
Canonical SMILES:
1.Determination of ciclopirox olamine in pharmaceutical products by capillary electrophoresis with capacitively coupled contactless conductivity detection.
Felix FS;do Lago CL;Angnes L Electrophoresis. 2011 Apr;32(8):900-5. doi: 10.1002/elps.201000612. Epub 2011 Mar 11.
This paper describes the determination of ciclopirox olamine in pharmaceutical formulations using capillary electrophoresis with capacitively coupled contactless conductivity detection. In an alkaline medium, ciclopirox olamine is converted into an anionic species and its detection is possible in capillary electrophoresis with capacitively coupled contactless conductivity detection without an electroosmotic flow modifier, because it is a low-mobility species. A linear working range from 2.64 to 264 μg/mL in sodium hydroxide electrolyte as well as low detection limit (0.39 μg/mL) and a good repeatability (RSD = 3.4% for 264 μg/mL ciclopirox solution (n = 10)) were achieved. It was also possible to determine olamine in its cationic form when acetic acid was used as the electrolyte solution. The results obtained include a linear range from 26.4 to 184.8 μg/mL and a detection limit of 2.6 μg/mL olamine. The proposed methods were applied to the analysis of commercial pharmaceutical products and the results were compared with the values indicated by the manufacturer as well as those obtained using a titrimetric method recommended by American Pharmacopoeia.
2.[In vitro antifungal spectrum of ciclopiroxolamine].
Goudard M;Regli P;Lubrano N Pathol Biol (Paris). 1989 Jun;37(5 Pt 2):621-3.
The ciclopiroxolamine is a new synthetic antifungal agent related to pyridones; it is the ethanolamine salt of the pyridone acid 6-cyclohexyl 1-hydroxy 4-methyl 2 (1H). The antifungal properties of this molecule was tested in vitro against pathogenic species such as yeasts. (Candida, Torulopsis, Malassezia), moulds (Aspergillus, Scopulariopsis) and dermatophytes, (Microsporum, Trichophyton, Epidermophyton) using an agar dilution method (Sabouraud or Dixon). The results seem to be remarkably homogeneous whatever the strain tested. The MIC obtained with moulds (less sensitive) range between 10-20 micrograms/ml. Whereas they range between 1 and 10 micrograms/ml with yeasts and dermatophytes. On account of the lack of in vivo toxicity of ciclopiroxolamine and of the level of concentrations used in dermatology (1% ointment), the ciclopiroxolamine has a particularly interesting broad spectrum on fungi which induce cutaneous mycoses.
3.In vitro evaluation of the antifungal efficacy of poloxamer 407-based formulations in an infected nail plate model.
Täuber A;Müller-Goymann CC Int J Pharm. 2016 May 30;505(1-2):20-3. doi: 10.1016/j.ijpharm.2016.01.082. Epub 2016 Mar 15.
The in vitro efficacy of poloxamer 407-based formulations with antifungal ciclopirox olamine has been analysed in an infected nail plate model. As artificial nail plates, keratin films made of human hair keratin and slices from bovine hooves have been utilised. Several poloxamer 407-based formulations with 1 % active ingredient indicated complete growth inhibition of the dermatophyte fungus Trichophyton rubrum after 6days of incubation.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Antifungal Products

CAS 114778-60-8 BRL44385

(CAS: 114778-60-8)

BRL44385, a novel guanine analogue, is a potent and selective inhibitor of herpes simplex virus types 1 and 2 and varicella zoster virus.

CAS 15893-52-4 DIMBOA

(CAS: 15893-52-4)

DIMBOA is an antifungal agent used in crops.

CAS 179463-17-3 Caspofungin Acetate

Caspofungin Acetate
(CAS: 179463-17-3)

Caspofungin acetate is the first in a new class of antifungals that inhibits the synthesis of beta (1, 3)-d-glucan, an essential component of the cell wall of f...

CAS 7681-93-8 Natamycin

(CAS: 7681-93-8)

Natamycin is a naturally occurring antifungal agent produced during fermentation by the bacterium Streptomyces natalensis with a MIC (minimum inhibitory concent...

CAS 118021-35-5 L-4-Oxalysine hydrochloride

L-4-Oxalysine hydrochloride
(CAS: 118021-35-5)

L-4-oxalysine is a natural product isolated from a new species of Streptomyces roseoÍiridofuscus n.sp. in China. L-4-oxalysine inhibits the proliferation of som...

CAS 35554-44-0 Enilconazole

(CAS: 35554-44-0)

Enilconazole Is An Agricultiral Fungicide, particularly in the growing of citrus fruits, also used as a topical antimycotic.

CAS 1265166-14-0 Antifungal agent 1

Antifungal agent 1
(CAS: 1265166-14-0)

A potent antifungalagent

CAS 187164-19-8 Luliconazole

(CAS: 187164-19-8)

Luliconazole is an azole antifungal indicated for the topical treatment of interdigital tinea pedis.

Chemical Structure

CAS 41621-49-2 Ciclopirox ethanolamine

Quick Inquiry

Verification code

Featured Items