Ciclopirox ethanolamine - CAS 41621-49-2
Catalog number: B0084-068466
Category: Inhibitor
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Ciclopirox ethanolamine (Ciclopirox olamine, HOE 296) is a broad-spectrum antifungal agent working as an iron chelator.
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B0084-068466 25 g $169 In stock
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1.Determination of ciclopirox olamine in pharmaceutical products by capillary electrophoresis with capacitively coupled contactless conductivity detection.
Felix FS;do Lago CL;Angnes L Electrophoresis. 2011 Apr;32(8):900-5. doi: 10.1002/elps.201000612. Epub 2011 Mar 11.
This paper describes the determination of ciclopirox olamine in pharmaceutical formulations using capillary electrophoresis with capacitively coupled contactless conductivity detection. In an alkaline medium, ciclopirox olamine is converted into an anionic species and its detection is possible in capillary electrophoresis with capacitively coupled contactless conductivity detection without an electroosmotic flow modifier, because it is a low-mobility species. A linear working range from 2.64 to 264 μg/mL in sodium hydroxide electrolyte as well as low detection limit (0.39 μg/mL) and a good repeatability (RSD = 3.4% for 264 μg/mL ciclopirox solution (n = 10)) were achieved. It was also possible to determine olamine in its cationic form when acetic acid was used as the electrolyte solution. The results obtained include a linear range from 26.4 to 184.8 μg/mL and a detection limit of 2.6 μg/mL olamine. The proposed methods were applied to the analysis of commercial pharmaceutical products and the results were compared with the values indicated by the manufacturer as well as those obtained using a titrimetric method recommended by American Pharmacopoeia.
2.[In vitro antifungal spectrum of ciclopiroxolamine].
Goudard M;Regli P;Lubrano N Pathol Biol (Paris). 1989 Jun;37(5 Pt 2):621-3.
The ciclopiroxolamine is a new synthetic antifungal agent related to pyridones; it is the ethanolamine salt of the pyridone acid 6-cyclohexyl 1-hydroxy 4-methyl 2 (1H). The antifungal properties of this molecule was tested in vitro against pathogenic species such as yeasts. (Candida, Torulopsis, Malassezia), moulds (Aspergillus, Scopulariopsis) and dermatophytes, (Microsporum, Trichophyton, Epidermophyton) using an agar dilution method (Sabouraud or Dixon). The results seem to be remarkably homogeneous whatever the strain tested. The MIC obtained with moulds (less sensitive) range between 10-20 micrograms/ml. Whereas they range between 1 and 10 micrograms/ml with yeasts and dermatophytes. On account of the lack of in vivo toxicity of ciclopiroxolamine and of the level of concentrations used in dermatology (1% ointment), the ciclopiroxolamine has a particularly interesting broad spectrum on fungi which induce cutaneous mycoses.
3.In vitro evaluation of the antifungal efficacy of poloxamer 407-based formulations in an infected nail plate model.
Täuber A;Müller-Goymann CC Int J Pharm. 2016 May 30;505(1-2):20-3. doi: 10.1016/j.ijpharm.2016.01.082. Epub 2016 Mar 15.
The in vitro efficacy of poloxamer 407-based formulations with antifungal ciclopirox olamine has been analysed in an infected nail plate model. As artificial nail plates, keratin films made of human hair keratin and slices from bovine hooves have been utilised. Several poloxamer 407-based formulations with 1 % active ingredient indicated complete growth inhibition of the dermatophyte fungus Trichophyton rubrum after 6days of incubation.
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CAS 41621-49-2 Ciclopirox ethanolamine

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