Ciclopirox - CAS 29342-05-0
Catalog number:
29342-05-0
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C12H17NO2
Molecular Weight:
207.27
COA:
Inquire
Targets:
Antifungal
Description:
Ciclopirox olamine (used in preparations called Batrafen, Loprox, Rejuvenail, Mycoster, Penlac and Stieprox) is a synthetic antifungal agent for topical dermatologic treatment of superficial mycoses. It is most useful against Tinea versicolor.
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Purity:
>98%
Synonyms:
Ciclopirox
MSDS:
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1.Molecular-Level Control of Ciclopirox Olamine Release from Poly(ethylene oxide)-Based Mucoadhesive Buccal Films: Exploration of Structure-Property Relationships with Solid-State NMR.
Urbanova M1, Gajdosova M2, Steinhart M1, Vetchy D2, Brus J1. Mol Pharm. 2016 May 2;13(5):1551-63. doi: 10.1021/acs.molpharmaceut.6b00035. Epub 2016 Apr 5.
Mucoadhesive buccal films (MBFs) provide an innovative way to facilitate the efficient site-specific delivery of active compounds while simultaneously separating the lesions from the environment of the oral cavity. The structural diversity of these complex multicomponent and mostly multiphase systems as well as an experimental strategy for their structural characterization at molecular scale with atomic resolution were demonstrated using MBFs of ciclopirox olamine (CPX) in a poly(ethylene oxide) (PEO) matrix as a case study. A detailed description of each component of the CPX/PEO films was followed by an analysis of the relationships between each component and the physicochemical properties of the MBFs. Two distinct MBFs were identified by solid-state NMR spectroscopy: (i) at low API (active pharmaceutical ingredient) loading, a nanoheterogeneous solid solution of CPX molecularly dispersed in an amorphous PEO matrix was created; and (ii) at high API loading, a pseudoco-crystalline system containing CPX-2-aminoethanol nanocrystals incorporated into the interlamellar space of a crystalline PEO matrix was revealed.
2.Pharmacokinetics of Ciclopirox Olamine after Buccal Administration in Rabbits.
Lukášová I, Muselík J1, Vetchý D, Gajdziok J, Gajdošová M, Juřica J, Knotek Z, Hauptman K, Jekl V. Curr Drug Deliv. 2016 May 2. [Epub ahead of print]
Prevalence of oral mucosal fungal infections increases with the frequent administration of antibiotics, corticosteroids and immunosuppressive drugs. Therapeutically used antifungals are usually associated with a variety of drug interactions. Furthermore, there has been a noticeable increase in microorganisms resistant to these preparations. Mucoadhesive buccal films represent a modern therapeutic system for the treatment of oral mucosal fungal infection paired with a high degree of patient compliance. Ciclopirox olamine (CPX) applied directly onto the oral mucosa offers an attractive alternative to treatment with systemic antifungals thanks to its low incidence of resistance and side effects. The aim of this work was to evaluate the pharmacokinetic parameters of CPX after the buccal application of mucoadhesive film prepared by the solvent casting method. A chromatographic method using an internal standard was developed and validated for evaluation of CPX plasma concentrations.
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CAS 29342-05-0 Ciclopirox

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