Ciclesonide - CAS 126544-47-6
Catalog number:
126544-47-6
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C32H44O7
Molecular Weight:
540.69
COA:
Inquire
Targets:
Glucocorticoid Receptor
Description:
Ciclesonide, a glucocorticoid, could be useful in the treatment of sorts of airway inflammatory diseases like allergic rhinitis.
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Purity:
98%
Appearance:
White Solid
Synonyms:
(r)-11b,16a,17,21-tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with cyclohexanecarboxaldehyde 21-isobutyrate;(R)-11b,16a,17,21-Tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with cyclohexanecarboxaldehyde 21-isobutyrate;Cicles
Solubility:
10 mM in DMSO
Storage:
-20ºC Freeze
MSDS:
Inquire
Application:
Ciclesonide could be useful in the treatment of sorts of airway inflammatory diseases like allergic rhinitis.
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Quantity:
Milligrams-Grams
Boiling Point:
665ºC at 760 mmHg
Melting Point:
202-209°C
Density:
1.23 g/cm3
InChIKey:
LUKZNWIVRBCLON-GXOBDPJESA-N
InChI:
InChI=1S/C32H44O7/c1-18(2)28(36)37-17-25(35)32-26(38-29(39-32)19-8-6-5-7-9-19)15-23-22-11-10-20-14-21(33)12-13-30(20,3)27(22)24(34)16-31(23,32)4/h12-14,18-19,22-24,26-27,29,34H,5-11,15-17H2,1-4H3/t22-,23-,24-,26+,27+,29+,30-,31-,32+/m0/s1
Canonical SMILES:
CC(C)C(=O)OCC(=O)C12C(CC3C1(CC(C4C3CCC5=CC(=O)C=CC45C)O)C)OC(O2)C6CCCCC6
1.Combination therapy of tiotropium and ciclesonide attenuates airway inflammation and remodeling in a guinea pig model of chronic asthma.
Kistemaker LE1,2, Bos IS3,4, Menzen MH3,4, Maarsingh H5, Meurs H3,4, Gosens R3,4. Respir Res. 2016 Feb 4;17(1):13. doi: 10.1186/s12931-016-0327-6.
BACKGROUND: The long-acting anticholinergic tiotropium has recently been registered for the treatment of asthma, and its use is associated with a reduction in exacerbation frequency. Anti-inflammatory and anti-remodeling effects of tiotropium have been demonstrated in in vitro and in vivo models. Because tiotropium treatment is used in combination with inhaled corticosteroids, potential additive effects between the two would be clinically relevant. Therefore, the aim of this study was to investigate additive effects between tiotropium and ciclesonide on airway inflammation and remodeling in guinea pig models of asthma.
2.Efficacy of Low-Dose Ciclesonide and Fluticasone Propionate for Mild to Moderate Persistent Asthma.
Jamaati H1, Malekmohammad M2, Fahimi F3, Najafi A3, Hashemian SM3. Tanaffos. 2015;14(1):1-9.
BACKGROUND: The aim of this study was to compare the efficacy of ciclesonide (80 mg/day) and fluticasone propionate (200 mg/day) for mild to moderate persistent asthma.
3.Ciclesonide-induced bronchospasm: an important but preventable side effect.
Mandaliya PH1, Kennedy B2, van Asperen P2, Robinson PD2. Med J Aust. 2015 Sep 7;203(5):233.
4.Inhalational Ciclesonide found beneficial in prevention of fat embolism syndrome and improvement of hypoxia in isolated skeletal trauma victims.
Sen RK1, Prakash S2, Tripathy SK3,4, Agarwal A1, Sen IM5. Eur J Trauma Emerg Surg. 2016 Jan 18. [Epub ahead of print]
BACKGROUND: Many studies have established intravenous corticosteroid as an effective prophylactic therapy in fat embolism syndrome (FES). However, its use is limited among surgeons because of systemic side effects. Inhalational steroids have least systemic effects and are widely used for several chest conditions (i.e., asthma), but their effectiveness in FES has not been established.
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CAS 126544-47-6 Ciclesonide

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