CI 972 - CAS 115787-68-3
Catalog number:
115787-68-3
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C11H12ClN5OS
Molecular Weight:
297.76
COA:
Inquire
Targets:
Others
Description:
This active molecular is a potent purine nucleoside phosphorylase inhibitor and a T cell-selective immunosuppressive agent. CI-972 inhibited proliferation of human MOLT-4 (T cell) and not MGL-8 (B cell) lymphoblasts with respective IC50s of 3.0 and greater than 50 microM when tested with 10 microM 2'-deoxyguanosine. In Apr 1996, Immunological Disorders section added to drug profile and Immunological disorders in USA was discontinued.
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Purity:
98%
Appearance:
Powder
Synonyms:
4H-Pyrrolo(3,2-d)pyrimidin-4-one, 2,6-diamino-1,5-dihydro-7-(3-thienylmethyl)-, monohydrochloride
Solubility:
Soluble in DMSO
Storage:
-20°C Freezer
MSDS:
Inquire
Application:
Immunological disorders; Transplant rejection
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Quantity:
Milligrams-Grams
InChIKey:
SLNICZJKQXPOJA-UHFFFAOYSA-N
InChI:
1S/C11H11N5OS.ClH/c12-9-6(3-5-1-2-18-4-5)7-8(14-9)10(17)16-11(13)15-7;/h1-2,4,14H,3,12H2,(H3,13,15,16,17);1H
Canonical SMILES:
c1([nH]c2c(c(n1)=O)[nH]c(c2Cc1cscc1)N)N.Cl
Current Developer:
Originator:Pfizer
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

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