CI-1018 - CAS 245329-99-1
Catalog number: 245329-99-1
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C24H20N4O2
Molecular Weight:
396.44
COA:
Inquire
Targets:
Phosphodiesterase (PDE)
Description:
CI-1018 is a selective type 4 phosphodiesterase inhibitor associated with vasculitis. CI-1018 has been in development to suppress inflammation.
Publictions citing BOC Sciences Products
  • >> More
Purity:
>98%
Appearance:
Solid powder
Synonyms:
4-Pyridinecarboxamide, N-(3,4,6,7-tetrahydro-9-methyl-4-oxo-1-phenylpyrrolo(3,2,1-jk)(1,4)benzodiazepin-3-yl)-; CI-1018; CI-1018; CI-1018; UNII-05127JZ9KQ
MSDS:
Inquire
InChIKey:
KYFWUBJMTHVBIF-QFIPXVFZSA-N
InChI:
1S/C24H20N4O2/c1-15-13-18-9-12-28-21(18)19(14-15)20(16-5-3-2-4-6-16)26-22(24(28)30)27-23(29)17-7-10-25-11-8-17/h2-8,10-11,13-14,22H,9,12H2,1H3,(H,27,29)/t22-/m0/s1
Canonical SMILES:
CC1=CC2=C3C(=C1)C(=NC(C(=O)N3CC2)NC(=O)C4=CC=NC=C4)C5=CC=CC=C5
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Phosphodiesterase (PDE) Products


CP 461
(CAS: 227619-96-7)

CP 461, belonging to a class of novel proapoptotic drugs with antineoplastic effect, specifically inhibit cyclic GMP phosphodiesterases but not cyclooxygenase-1...

CAS 99519-84-3 L-651,582

L-651,582
(CAS: 99519-84-3)

L-651,582 is a novel inhibitor of both cAMP-phosphodiesterases and GMP-phosphodiesterases. It is also an orally active calcium channel blocker. It prevents oxid...

CAS 60719-84-8 Amrinone

Amrinone
(CAS: 60719-84-8)

Amrinone is a selective cAMP phosphodiesterase (PDE-3) inhibitor with positive inotropic and vasodilatory activity. It is a simple, non-glycoside cardiotonic ag...

CAS 115344-47-3 Siguazodan

Siguazodan
(CAS: 115344-47-3)

Siguazodan is a selective phosphodiesterase 3 (PDE3) inhibitor (IC50 = 117 nM). Siguazodan acts as a potent vasodilator.

PDE10-IN-1 is a potent PDE10-IN-1 inhibi
(CAS: 1516896-09-5)

PDE10-IN-1 is a potent PDE10-IN-1 inhibitor which can be used to treat CNS disorders and metabolic disorders.

CAS 171599-83-0 Sildenafil Citrate

Sildenafil Citrate
(CAS: 171599-83-0)

Sildenafil, a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5), is a well-tolerated and highly effective tr...

CAS 1238697-26-1 TAK-063

TAK-063
(CAS: 1238697-26-1)

TAK-063 is a highly potent, selective, and orally active phosphodiesterase 10A (PDE10A) inhibitor. TAK-063 is currently being evaluated in clinical trials for t...

CAS 257892-33-4 AWD 12-281

AWD 12-281
(CAS: 257892-33-4)

AWD 12-281 is a strong selective phosphodiesterase 4 (PDE4) inhibitor which has potent effects in models of lung inflammation using inhalative administration.

CAS 78415-72-2 Milrinone

Milrinone
(CAS: 78415-72-2)

Milrinone is a phosphodiesterase 3 (PDE3) inhibitor with vasodilator properties, used to increase the heart's contractility. It increases erythrocyte cAMP activ...

CI-1018
(CAS: 245329-99-1)

CI-1018 is a selective type 4 phosphodiesterase inhibitor associated with vasculitis. CI-1018 has been in development to suppress inflammation.

CAS 224785-90-4 Vardenafil HCl Trihydrate

Vardenafil HCl Trihydrate
(CAS: 224785-90-4)

Vardenafil HCl Trihydrate is a new type PDE inhibitor with IC50 of 0.7 and 180 nM for PDE5 and PDE1, respectively. Vardenafil was co-marketed by Bayer Pharmaceu...

CAS 171596-36-4 Nortadalafil

Nortadalafil
(CAS: 171596-36-4)

A N-desmethyl analogue of the human PDE5 inhibitor Tadalafil. A potential antiplasmodial drug.

CAS 58579-51-4 Anagrelide Hydrochloride

Anagrelide Hydrochloride
(CAS: 58579-51-4)

Anagrelide is a drug used for the treatment of essential thrombocytosis,or overproduction of blood platelets. It also has been used in the treatment of chronic ...

ITI214
(CAS: 1642303-38-5)

ITI214 is a highly selective PDE1 inhibitor (Ki = 58 pM) at picomolar concentration without disrupting other PDE family members and a panel of enzymes, receptor...

CAS 794568-92-6 BAY 73-6691

BAY 73-6691
(CAS: 794568-92-6)

BAY 73-6691 is a phosphodiesterase inhibitor selective for the PDE9A subtype under the development of Bayer. It selectively inhibits human PDE9 with IC50 value ...

CAS 1440898-82-7 Deltarasin hydrochloride

Deltarasin hydrochloride
(CAS: 1440898-82-7)

Small molecule inhibitor of the KRAS–PDEδ interaction that impairs oncogenic KRAS signalling by altering its localization to endomembranes (in cell Kd value 41 ...

CAS 1160521-50-5 PDE1-IN-1

PDE1-IN-1
(CAS: 1160521-50-5)

PDE1-IN-1 is a potent PDE1 inhibitor and neuroprotective agent.

CAS 2066488-39-7 (S)-C33

(S)-C33
(CAS: 2066488-39-7)

(S)-C33 is a potent and selective PDE9 inhibitor (IC50 = 11 nM).

CAS 78033-08-6 MMPX

MMPX
(CAS: 78033-08-6)

MMPX is a specific inhibitor of calmodulin-sensitive cyclic GMP phosphodiesterase (IC50 = 5.2 μM). It causes an increase in cGMP but not cAMP, prolonging signal...

CAS 939055-18-2 FIPI

FIPI
(CAS: 939055-18-2)

FIPI, a derivative of halopemide, is a potent and selective phospholipase D (PLD) inhibitor with IC50 values of 20 and 25 nM for PLD2 and PLD1 respectively. It ...

Quick Inquiry

Verification code

Featured Items