Chrysoeriol - CAS 491-71-4
Catalog number: B0005-119355
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Chrysoeriol is a natural compound isolated from the herbs of Medicago sativa. Chrysoeriol can potently inhibit the induction of nitric oxide synthase by blocking activator protein 1 (AP-1) activation and its anti-inflammatory effects. Chrysoeriol can induce nod genes in rhizobium meliloti. Chrysoeriol can inhibit the downstream signal transduction pathways of platelet-derived growth factor (PDGF)-Rbeta, including ERK1/2, p38, and Akt phosphorylation, which suggests that chrysoeriol may be used for the prevention and treatment of vascular diseases during restenosis after coronary angioplasty.
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B0005-119355 25 mg $298 In stock
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Yellow powder
1. 5,7-Dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4-benzopyrone
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1.Effects of Various 5,7-Dihydroxyflavone Analogs on Adipogenesis in 3T3-L1 Cells.
Nishina A1, Ukiya M, Fukatsu M, Koketsu M, Ninomiya M, Sato D, Yamamoto J, Kobayashi-Hattori K, Okubo T, Tokuoka H, Kimura H. Biol Pharm Bull. 2015;38(11):1794-800. doi: 10.1248/bpb.b15-00489.
We studied the effects of twelve 5,7-dihydroxyflavone analogs on adipogenesis in 3T3-L1 cells. Among the compounds, luteolin, diosmetin, and chrysoeriol partly inhibited adipogenesis by blocking the accumulation of triacylglycerol in the cells. Conversely, tricetin facilitated triacylglycerol accumulation in the cells. The induction of lipogenesis or lipolysis may depend on the number and bonding position of hydroxyl or methoxy groups on the B ring of 5,7-dihydroxyflavone. The mRNA expression levels of adipogenic and lipogenic genes were suppressed by luteolin treatment in the cells, while the mRNA levels of lipolytic genes were not affected. However, the expression levels of the adipogenic, lipogenic, and lipolytic genes, except for adipocyte protein 2 (aP2), were not affected by the addition of tricetin. Moreover, luteolin suppressed glucose transporter type 4 (GLUT4) gene and protein levels. These results indicate that luteolin decreased triacylglycerol levels in 3T3-L1 cells during adipogenesis through the suppression of adipogenic/lipogenic and GLUT4 genes and GLUT4 protein.
2.[Chemical Constituents from Angelica keiskei].
Yao YZ, Li SH. Zhong Yao Cai. 2015 Aug;38(8):1656-60.
OBJECTIVE: To investigate the chemical constituents from Angelica keiskei.
3.Phenolic Derivatives of Artemisia Spicigera C. Koch Growing in Iran.
Heshmati Afshar F1, Delazar A2, Nazemiyeh H2, Khodaie L3, Bamdad Moghaddam S4. Iran J Pharm Res. 2015 Fall;14(4):1241-6.
This study aimed to determine phenolic compounds of Artemisia spicigera (family Asteraceae) growing in East-Azarbaijan province of Iran. 20%, 40 % and 60% SPE fractions of methanolic extract of A. spicigera, were subjected to reversed phase preparative HPLC, with the mobile phase consisted of methanol and water. Structural identification of phytochemicals by spectroscopic methods including UV and NMR spectroscopy, yielded 4, 6-di methoxy acetophenone-2-O-β-D-glucopyranoside from 20%, 5-methoxyluteolin 7-O-β-D-glucopyranoside, luteolin and chrysoeriol 7-O-β-D-glucopyranoside from 40% and 5-methoxy luteolin from 60% SPE fractions. Although within identified pure compounds, luteolin was the only phenolic reported from some other species of Artemisia, but occurrence of remained identified phenolics in this study, was firstly reported from Artemisia genus. Further phytochemical investigations were proposed in order to isolate some other active fractions and pure compounds.
4.Metabolite profiling in 18 Saudi date palm fruit cultivars and their antioxidant potential via UPLC-qTOF-MS and multivariate data analyses.
Farag MA1, Handoussa H2, Fekry MI1, Wessjohann LA3. Food Funct. 2016 Feb 17;7(2):1077-86. doi: 10.1039/c5fo01570g.
Date palm fruit (Phoenix dactylifera) is not only one of the most economically significant plants in the Middle East, but also valued for its nutritional impact, and for which development of analytical methods is ongoing to help distinguish its many cultivars. This study attempts to characterize the primary and secondary metabolite profiles of 18 date cultivars from Saudi Arabia. A total of 44 metabolites extracted from the fruit peel were evaluated in a UPLC-qTOF-MS based metabolomics analysis including flavonoids, phenolic acids and fatty acids. The predominant flavones were glycosides of luteolin and chrysoeriol, as well as quercetin conjugates, whereas caffeoyl shikimic acid was the main hydroxycinnamic acid conjugate. GC-MS was further utilized to identify the primary metabolites in fruits (i.e. sugars) with glucose and fructose accounting for up to 95% of TIC among most cultivars. PCA and OPLS analyses revealed that flavone versus flavonol distribution in fruit were the main contributors for cultivar segregation.
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CAS 491-71-4 Chrysoeriol

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