Choline Fenofibrate - CAS 856676-23-8
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Not Intended for Therapeutic Use. For research use only.
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Choline Fenofibrate is the choline salt of fenofibric acid under clinical development as a combination therapy with rosuvastatin for the management of dyslipidemia.
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B0084-259938 5 g $249 In stock
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1.Novel fenofibric acid-loaded controlled release pellet bioequivalent to choline fenofibrate-loaded commercial product in beagle dogs.
Kim KS1, Jin SG2, Mustapha O2, Yousaf AM2, Kim DW2, Kim YH1, Kim JO3, Yong CS3, Woo JS4, Choi HG5. Int J Pharm. 2015 Jul 25;490(1-2):273-80. doi: 10.1016/j.ijpharm.2015.05.059. Epub 2015 May 27.
The objective of this study was to develop a novel fenofibric acid-loaded controlled release pellet showing enhanced, or equivalent to, bioavailability compared with two commercially available products containing fenofibrate or choline fenofibrate. The effect of solubilizing agents on drug solubility and the impact of fillers on core properties were investigated. Among them, magnesium carbonate most improved drug solubility, and κ-carrageenan provided the best spherical cores. The fenofibric acid-loaded pellet was prepared with magnesium carbonate and κ-carrageenan employing the extrusion/spheronizing technique followed by coating with ethylcellulose. Furthermore, dissolution and pharmacokinetic study in beagle dogs were performed compared to the fenofibrate-loaded commercial tablet (FCT) and choline fenofibrate-loaded commercial mini-tablet (CFCM). This fenofibric acid-loaded pellet showed controlled release of the drug in phosphate buffer (pH 6.
2.Comparison of efficacy and safety of choline fenofibrate (fenofibric acid) to micronized fenofibrate in patients of mixed dyslipidemia: A randomized, open-label, multicenter clinical trial in Indian population.
Patel P1, Barkate H1. Indian J Endocrinol Metab. 2016 Jan-Feb;20(1):67-71. doi: 10.4103/2230-8210.172243.
INTRODUCTION: Choline fenofibrate is a newly developed choline salt of fenofibric acid, which is more hydrophilic than fenofibrate. This study was initiated to evaluate the safety and efficacy of choline fenofibrate in comparison to micronized fenofibrate among Indian patients of mixed dyslipidemia.
3.Fenofibrate causes elevation of betaine excretion but not excretion of other osmolytes by healthy adults.
Lever M1, McEntyre CJ2, George PM3, Slow S3, Chambers ST4, Foucher C5. J Clin Lipidol. 2014 Jul-Aug;8(4):433-40. doi: 10.1016/j.jacl.2014.04.001. Epub 2014 Apr 16.
BACKGROUND: Cross-sectional data suggest that bezafibrate increases betaine excretion in dyslipidemic patients.
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CAS 856676-23-8 Choline Fenofibrate

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