Choline Fenofibrate - CAS 856676-23-8
Catalog number:
B0084-259938
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C22H28ClNO5
Molecular Weight:
421.91
COA:
Inquire
Targets:
Others
Description:
Choline Fenofibrate is the choline salt of fenofibric acid under clinical development as a combination therapy with rosuvastatin for the management of dyslipidemia.
Ordering Information
Catalog Number Size Price Stock Quantity
B0084-259938 5 g $249 In stock
Bulk Inquiry
Publictions citing BOC Sciences Products
  • >> More
Purity:
>98%
Synonyms:
ABT-335
MSDS:
Inquire
1.Novel fenofibric acid-loaded controlled release pellet bioequivalent to choline fenofibrate-loaded commercial product in beagle dogs.
Kim KS1, Jin SG2, Mustapha O2, Yousaf AM2, Kim DW2, Kim YH1, Kim JO3, Yong CS3, Woo JS4, Choi HG5. Int J Pharm. 2015 Jul 25;490(1-2):273-80. doi: 10.1016/j.ijpharm.2015.05.059. Epub 2015 May 27.
The objective of this study was to develop a novel fenofibric acid-loaded controlled release pellet showing enhanced, or equivalent to, bioavailability compared with two commercially available products containing fenofibrate or choline fenofibrate. The effect of solubilizing agents on drug solubility and the impact of fillers on core properties were investigated. Among them, magnesium carbonate most improved drug solubility, and κ-carrageenan provided the best spherical cores. The fenofibric acid-loaded pellet was prepared with magnesium carbonate and κ-carrageenan employing the extrusion/spheronizing technique followed by coating with ethylcellulose. Furthermore, dissolution and pharmacokinetic study in beagle dogs were performed compared to the fenofibrate-loaded commercial tablet (FCT) and choline fenofibrate-loaded commercial mini-tablet (CFCM). This fenofibric acid-loaded pellet showed controlled release of the drug in phosphate buffer (pH 6.
2.Comparison of efficacy and safety of choline fenofibrate (fenofibric acid) to micronized fenofibrate in patients of mixed dyslipidemia: A randomized, open-label, multicenter clinical trial in Indian population.
Patel P1, Barkate H1. Indian J Endocrinol Metab. 2016 Jan-Feb;20(1):67-71. doi: 10.4103/2230-8210.172243.
INTRODUCTION: Choline fenofibrate is a newly developed choline salt of fenofibric acid, which is more hydrophilic than fenofibrate. This study was initiated to evaluate the safety and efficacy of choline fenofibrate in comparison to micronized fenofibrate among Indian patients of mixed dyslipidemia.
3.Fenofibrate causes elevation of betaine excretion but not excretion of other osmolytes by healthy adults.
Lever M1, McEntyre CJ2, George PM3, Slow S3, Chambers ST4, Foucher C5. J Clin Lipidol. 2014 Jul-Aug;8(4):433-40. doi: 10.1016/j.jacl.2014.04.001. Epub 2014 Apr 16.
BACKGROUND: Cross-sectional data suggest that bezafibrate increases betaine excretion in dyslipidemic patients.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Products


CAS 1596-84-5 Daminozide

Daminozide
(CAS: 1596-84-5)

Daminozide is a highly selective inhibitor of the human 2-oxoglutarate (JmjC) histone demethylases KDM2A, PHF8, and KDM7A with IC50 values of 1.5, 0.55, and 2.1...

GSK894490A
(CAS: 1012035-06-1)

GSK894490A is a non-peptide ghrelin receptor agonist. It crosses the blood/brain barrier and elicit pro-cognitive effects in recognition and spatial learning an...

Sortin1
(CAS: 503837-98-7)

Sortin1 is a synthetic chemical ats as a Sorting inhibitor, redirecting the vacuolar destination of plant carboxypeptidase Y and other proteins in Arabidopsis.

CAS 119-41-5 Efloxate

Efloxate
(CAS: 119-41-5)

Efloxate, a flavone derivative, could be effective in the treatment of chronic coronary insufficiency and angina pectoris for acting as a vasodilator.

CAS 58-94-6 Chlorothiazide

Chlorothiazide
(CAS: 58-94-6)

Chlorothiazide is a diuretic and antihypertensive. (IC50=3.8 mM)

CAS 110314-48-2 Adolezesin

Adolezesin
(CAS: 110314-48-2)

Adozelesin is an experimental antitumor drug of the duocarmycin class. It is the first of a class of DNA-sequence-selective alkylating agents. It binds to and a...

RVX297
(CAS: 1044871-04-6)

RVX297 is a BD2 selective inhibitor of BET bromodomains. It is structurally related to the clinical compound RVX-208. It has significant implications on differe...

CAS 98753-19-6 Cefpirome Sulfate

Cefpirome Sulfate
(CAS: 98753-19-6)

Cefpirome Sulfate is a fourth generation cephalosporin antibiotic. It was developed by German company Hoechst and France Roussel company together.

CAS 108929-03-9 ML-23

ML-23
(CAS: 108929-03-9)

ML-23 is a melatonin analogue. It is a potential clinical candidate for the treatment of Parkinson's disease. It produced a significant remission from MPTP-indu...

CAS 209467-52-7 Ceftobiprole

Ceftobiprole
(CAS: 209467-52-7)

Ceftobiprole is a cephalosporin prodrug with potent bactericidal activity against methicillin-resistant MRSA and penicillin-resistant Streptococcus pneumoniae (...

CAS 606-68-8 NADH (disodium salt)

NADH (disodium salt)
(CAS: 606-68-8)

NADH becomes oxidized to produce NAD+, NAD usually acts as a hydrogen acceptor, forming NADH which then serves as a hydrogen donor in the respiratory chain.

N-Desmethyl Regorafenib
(CAS: 1343498-72-5)

N-Desmethyl Regorafenib is a metabolite of Regorafenib. Regorafenib is useful for the treatment of inflammation and as an anti-proliferative agent.

CAS 586357-02-0 O-Desmethyl Mebeverine Acid

O-Desmethyl Mebeverine Acid
(CAS: 586357-02-0)

O-Desmethyl Mebeverine Acid is a metabolite of Mebeverine, which is an antispasmodic.

Amedalin Hydrochloride
(CAS: 22232-73-1)

Amedalin Hydrochloride, with antidepressant effect, is a selective norepinephrine reuptake inhibitor.

CP-5068
(CAS: 352305-79-4)

CP-5068 is a synthetic bio-active chemical.

MRT-92
(CAS: 1428315-82-5)

CAS 1867-73-8 N6-methyladenosine

N6-methyladenosine
(CAS: 1867-73-8)

N6-Methyladenosine is an abundant modification in mRNA and is found within some viruses, and most eukaryotes including mammals, insects, plants and yeast.

DAA-1106
(CAS: 220551-92-8)

DAA-1106, with anxiolytic effects in mice, is a selective ligand for peripheral benzodiazepine receptor (PBR) and a selective agonist at the peripheral benzodia...

Morinidazole
(CAS: 92478-27-8)

Morinidazole is a novel 5-nitroimidazole antimicrobial drug. It undergoes extensive metabolism in humans via N+-glucuronidation and sulfation. It is used for th...

CAS 195514-80-8 AP20187

AP20187
(CAS: 195514-80-8)

Systemic AP20187 administration results in time-dependent LFv2IRE tyrosine phosphorylation and activation of the insulin signaling pathway in both liver and mus...

Chemical Structure

CAS 856676-23-8 Choline Fenofibrate

Quick Inquiry

Verification code

Featured Items