Choline Chloride - CAS 67-48-1
Catalog number: 67-48-1
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
C5H14NO·Cl
Molecular Weight:
139.62
COA:
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Targets:
Others
Description:
Choline chloride is a quaternary ammonium salt used as an additive for animal feed, especially for chickens where it accelerates growth.
Purity:
>98%
MSDS:
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InChIKey:
SGMZJAMFUVOLNK-UHFFFAOYSA-M
InChI:
InChI=1S/C5H14NO.ClH/c1-6(2,3)4-5-7;/h7H,4-5H2,1-3H3;1H/q+1;/p-1
Canonical SMILES:
C[N+](C)(C)CCO.[Cl-]
1.The role of rumen-protected choline in hepatic function and performance of transition dairy cows.
Shahsavari A1, D'Occhio MJ2, Al Jassim R1. Br J Nutr. 2016 May 3:1-10. [Epub ahead of print]
High-producing dairy cows enter a period of negative energy balance during the first weeks of lactation. Energy intake is usually sufficient to cover the increase in energy requirements for fetal growth during the period before calving, but meeting the demand for energy is often difficult during the early stages of lactation. A catabolic state predominates during the transition period, leading to the mobilisation of energy reserves (NEFA and amino acids) that are utilised mainly by the liver and muscle. Increased uptake of mobilised NEFA by the liver, combined with the limited capacity of hepatocytes to either oxidise fatty acids for energy or to incorporate esterified fatty acids into VLDL results in fatty liver syndrome and ketosis. This metabolic disturbance can affect the general health, and it causes economic losses. Different nutritional strategies have been used to restrict negative effects associated with the energy challenge in transition cows.
2.Prenatal choline supplementation attenuates spatial learning deficits of offspring rats exposed to low-protein diet during fetal period.
Zhu CH1, Wu T2, Jin Y3, Huang BX4, Zhou RF5, Wang YQ6, Luo XL7, Zhu HL8. J Nutr Biochem. 2015 Sep 13;32:163-170. doi: 10.1016/j.jnutbio.2015.09.003. [Epub ahead of print]
Prenatal intake of choline has been reported to lead to enhanced cognitive function in offspring, but little is known about the effects on spatial learning deficits. The present study examined the effects of prenatal choline supplementation on developmental low-protein exposure and its potential mechanisms. Pregnant female rats were fed either a normal or low-protein diet containing sufficient choline (1.1g/kg choline chloride) or supplemented choline (5.0g/kg choline chloride) until delivery. The Barnes maze test was performed at postnatal days 31-37. Choline and its metabolites, the synaptic structural parameters of the CA1 region in the brain of the newborn rat, were measured. The Barnes maze test demonstrated that prenatal low-protein pups had significantly greater error scale values, hole deviation scores, strategy scores and spatial search strategy and had lesser random search strategy values than normal protein pups (all P<.05).
3.Characterization of new eye drops with choline salicylate and assessment of their irritancy by in vitro short time exposure tests.
Wroblewska K1, Kucinska M2, Murias M2, Lulek J1. Saudi Pharm J. 2015 Sep;23(4):407-12. doi: 10.1016/j.jsps.2014.11.009. Epub 2014 Dec 9.
The aim of our study was to examine the irritation potential of new eye drops containing 2% choline salicylate (CS) as an active pharmaceutical ingredient (API) and various polymers increasing eye drop viscosity (hydroxyethylcellulose, hydroxypropyl methylcellulose, methylcellulose, polyvinyl alcohol, polyvinylpyrrolidone). The standard method for assessing the potential of irritating substances has been the Draize rabbit eye test. However the European Centre for Validation of Alternative Methods and the Coordinating Committee for Validation of Alternative Methods recommend, short time exposure (STE) in vitro tests as an alternative method for assessing eye irritation. The eye irritation potential was determined using cytotoxicity test methods for rabbit corneal cell line (SIRC) after 5 min exposure. The viability of cells was determined using two cytotoxicity assays: MTT and Neutral Red Uptake. According to the irritation rankings for the short time exposure test, all tested eye drops are classified as non-irritating (cell viability >70%).
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CAS 67-48-1 Choline Chloride

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