|Description||Cholesterol is the principal sterol of all higher animals required to build and maintain membranes.|
CVT10216 is a potent and selective, reversible inhibitor of aldehyde dehydrogenase 2 (ALDH2) with IC50 value of 29nM, thereby inhibiting dopamine synthesis. It ...
Bakuchiol is a phytoestrogen isolated from the seeds of Psoralea corylifolia L with an anti-tumor effects.
DPO-1, a blocker of IKur ultrarapid delayed rectifier potassium current and KV1.5 channels, has been found to exhibit activities in preventing atrial arrhythmia...
Monohydroxy Netupitant is the metabolite of Netupitant which is a potent and selective neurokinin-1 receptor (NK1) receptor antagonist. It is achiral and orally...
NAI-N3 is a novel RNA acylation reagent that enables RNA purification.
Ro 48-8071 fumarate
Ro 48-8071 is an orally active cholesterol synthesis inhibitor or a 2,3-oxidosqualene:lanosterol cyclase (OSC) inhibitor. OSC (EC 22.214.171.124) represents a unique ...
GKT137831 attenuates hypoxia-induced H(2)O(2) release, cell proliferation, and TGF-β1 expression and blunted reductions in PPARγ in HPAECs and HPASMCs.
LP-935509 is a brain penetrant inhibitor of adapter protein-2 associated kinase 1 (AAK1; IC50 value 3.3 nM and 14 nM and 320 nM for the closely related BIKE and...
PYR-0503, a pyrrole compound, could be commonly used in production of sorts of important compounds like some anticancer drugs and porphyrins.
Erlosiban, an iminopyrrolidin derivative, has been found to be a nonpeptide oxytocin receptor antagonist that could probably be used in the treatment of female ...
GSK 4112, a kind of synthetic agonist of REV-ERBα, could suppress the expression of sorts of genes involved in gluconeogenesis. IC50: 0.4 μM (EC50).
CP-744809 is a highly selective orally available small molecule inhibitor of aldose reductase.
CGP 47072, a bisphosphonate derivative, has been found to be a calcium regulator and was once studied in the treatment of osteoporosis.
GAT-100, an indole derivative, has been found to be a negative allosteric modulator that could be used as a covalent probe in studying of the binding motifs of ...
PF 4800567 is a potent and selective casein kinase 1ε (Csnk1e or CK-1ε) inhibitor (IC50 = 32 nM).
Lubiprostone induces a robust secretory response in T84 monolayers. Lubiprostone induces a rise in cAMP levels that was sensitive to EP(4)-receptor blockage in ...
L-AP6 is a selective agonist for 'quis'-sensitized site.
TC-E 5003 is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor (IC50 = 1.5 μM) with no inhibitory effects on CARM1 and Set7/9 methyltransferase...
Thiodiglycol, the hydrolysis product of sulfur mustard, is useful in textile dyeing and sorts of pen ink manufacturing. It could produce mustard gas reacted wit...
Ponatinib hydrochloride is an oral drug for the treatment of chronic myeloid leukemia (CML) and Philadelphia chromosome–positive (Ph+) acute lymphoblastic leuke...