Chlorzoxazone - CAS 95-25-0
Catalog number: 95-25-0
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
C7H4ClNO2
Molecular Weight:
169.57
COA:
Inquire
Targets:
Cytochrome P450
Description:
Chlorzoxazone is a muscle-relaxing drug, and a probe for human liver cytochrome P-450IIE1.
Purity:
>98%
Synonyms:
Chlorzoxazone; Paraflex; 5-Chloro-2-benzoxazolone; Chlorzoxazon; Myoflexin; McNeil Brand of Chlorzoxazone; Ortho Brand of Chlorzoxazone; Paraflex; Parafon; Parafon; Forte; DSC;
MSDS:
Inquire
InChIKey:
TZFWDZFKRBELIQ-UHFFFAOYSA-N
InChI:
InChI=1S/C7H4ClNO2/c8-4-1-2-6-5(3-4)9-7(10)11-6/h1-3H,(H,9,10)
Canonical SMILES:
C1=CC2=C(C=C1Cl)NC(=O)O2
1.Novel pure component contribution, mean centering of ratio spectra and factor based algorithms for simultaneous resolution and quantification of overlapped spectral signals: An application to recently co-formulated tablets of chlorzoxazone, aceclofenac an
Toubar SS1, Hegazy MA2, Elshahed MS1, Helmy MI1. Spectrochim Acta A Mol Biomol Spectrosc. 2016 Jun 15;163:89-95. doi: 10.1016/j.saa.2016.03.035. Epub 2016 Mar 24.
In this work, resolution and quantitation of spectral signals are achieved by several univariate and multivariate techniques. The novel pure component contribution algorithm (PCCA) along with mean centering of ratio spectra (MCR) and the factor based partial least squares (PLS) algorithms were developed for simultaneous determination of chlorzoxazone (CXZ), aceclofenac (ACF) and paracetamol (PAR) in their pure form and recently co-formulated tablets. The PCCA method allows the determination of each drug at its λmax. While, the mean centered values at 230, 302 and 253nm, were used for quantification of CXZ, ACF and PAR, respectively, by MCR method. Partial least-squares (PLS) algorithm was applied as a multivariate calibration method. The three methods were successfully applied for determination of CXZ, ACF and PAR in pure form and tablets. Good linear relationships were obtained in the ranges of 2-50, 2-40 and 2-30μgmL(-1) for CXZ, ACF and PAR, in order, by both PCCA and MCR, while the PLS model was built for the three compounds each in the range of 2-10μgmL(-1).
2.A pharmaceutical study on chlorzoxazone orodispersible tablets: formulation, in-vitro and in-vivo evaluation.
Moqbel HA1, ElMeshad AN1, El-Nabarawi MA1. Drug Deliv. 2016 Feb 1:1-10. [Epub ahead of print]
CONTEXT: Muscle spasm needs prompt relief of symptoms. Chlorzoxazone is a centrally muscle relaxant.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Cytochrome P450 Products


CAS 95-25-0 Chlorzoxazone

Chlorzoxazone
(CAS: 95-25-0)

Chlorzoxazone is a muscle-relaxing drug, and a probe for human liver cytochrome P-450IIE1.

CAS 56-54-2 Conquinine

Conquinine
(CAS: 56-54-2)

Conquinine is a Cytochrome P450 2D6 inhibitor. It is a dextrorotatory stereoisomer of quinine extracted from the bark of the Cinchona tree and similar plant spe...

CAS 115575-11-6 Liarozole

Liarozole
(CAS: 115575-11-6)

This active molecular has a potential antineoplastic activity. As a retinoic acid metabolism blocking agent (RAMBA), liarozole inhibits P450-dependent ATRA-4-hy...

CAS 520-36-5 Apigenin

Apigenin
(CAS: 520-36-5)

Apigenin (4',5,7-trihydroxyflavone), found in many plants, is a natural product belonging to the flavone class that is the aglycone of several naturally occurri...

CAS 201410-53-9 Talarozole

Talarozole
(CAS: 201410-53-9)

Talarozole, a retinoic acid metabolism blocking agent (RAMBA), is a potent and selective inhibitor of cytochrome P450 26 to treat dermatalogical diseases includ...

CAS 54-36-4 Metyrapone

Metyrapone
(CAS: 54-36-4)

Metyrapone acts as a glucocorticoid synthesis inhibitor, blocks cortisol synthesis by inhibiting steroid 11β-hydroxylase in adrenal cortex (IC50 = 7.8 μM).

Dafadine-A
(CAS: 1065506-69-5)

Dafadine-A, the first identified chemical inhibitor of DAF-9, could restrain the dauer formation, developmental timing and longevity in the nematodeCaenorhabdit...

CAS 83657-22-1 Uniconazole

Uniconazole
(CAS: 83657-22-1)

Uniconazole is a plant growth hormone that inhibits cytochrome P450 707As, resulting in a suppression of gibberellin production.

Chemical Structure

CAS 95-25-0 Chlorzoxazone

Quick Inquiry

Verification code

Featured Items