Chlorzoxazone - CAS 95-25-0
Catalog number: 95-25-0
Category: Inhibitor
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Cytochrome P450
Chlorzoxazone is a muscle-relaxing drug, and a probe for human liver cytochrome P-450IIE1.
Chlorzoxazone; Paraflex; 5-Chloro-2-benzoxazolone; Chlorzoxazon; Myoflexin; McNeil Brand of Chlorzoxazone; Ortho Brand of Chlorzoxazone; Paraflex; Parafon; Parafon; Forte; DSC;
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1.Novel pure component contribution, mean centering of ratio spectra and factor based algorithms for simultaneous resolution and quantification of overlapped spectral signals: An application to recently co-formulated tablets of chlorzoxazone, aceclofenac an
Toubar SS1, Hegazy MA2, Elshahed MS1, Helmy MI1. Spectrochim Acta A Mol Biomol Spectrosc. 2016 Jun 15;163:89-95. doi: 10.1016/j.saa.2016.03.035. Epub 2016 Mar 24.
In this work, resolution and quantitation of spectral signals are achieved by several univariate and multivariate techniques. The novel pure component contribution algorithm (PCCA) along with mean centering of ratio spectra (MCR) and the factor based partial least squares (PLS) algorithms were developed for simultaneous determination of chlorzoxazone (CXZ), aceclofenac (ACF) and paracetamol (PAR) in their pure form and recently co-formulated tablets. The PCCA method allows the determination of each drug at its λmax. While, the mean centered values at 230, 302 and 253nm, were used for quantification of CXZ, ACF and PAR, respectively, by MCR method. Partial least-squares (PLS) algorithm was applied as a multivariate calibration method. The three methods were successfully applied for determination of CXZ, ACF and PAR in pure form and tablets. Good linear relationships were obtained in the ranges of 2-50, 2-40 and 2-30μgmL(-1) for CXZ, ACF and PAR, in order, by both PCCA and MCR, while the PLS model was built for the three compounds each in the range of 2-10μgmL(-1).
2.A pharmaceutical study on chlorzoxazone orodispersible tablets: formulation, in-vitro and in-vivo evaluation.
Moqbel HA1, ElMeshad AN1, El-Nabarawi MA1. Drug Deliv. 2016 Feb 1:1-10. [Epub ahead of print]
CONTEXT: Muscle spasm needs prompt relief of symptoms. Chlorzoxazone is a centrally muscle relaxant.
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