Chlorquinaldol - CAS 72-80-0
Catalog number:
Not Intended for Therapeutic Use. For research use only.
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Molecular Weight:
Chlorquinaldol is an antimicrobial agent.
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BM-14190, SKF 105517
1.A comparative study of novel spectrophotometric resolution techniques applied for pharmaceutical mixtures with partially or severely overlapped spectra.
Lotfy HM1, Tawakkol SM2, Fahmy NM3, Shehata MA1. Spectrochim Acta A Mol Biomol Spectrosc. 2015 Feb 5;136 Pt B:937-52. doi: 10.1016/j.saa.2014.09.117. Epub 2014 Oct 12.
Simultaneous determination of mixtures of lidocaine hydrochloride (LH), flucortolone pivalate (FCP), in presence of chlorquinaldol (CQ) without prior separation steps was applied using either successive or progressive resolution techniques. According to the concentration of CQ the extent of overlapping changed so it can be eliminated from the mixture to get the binary mixture of LH and FCP using ratio subtraction method for partially overlapped spectra or constant value via amplitude difference followed by ratio subtraction or constant center followed by spectrum subtraction spectrum subtraction for severely overlapped spectra. Successive ratio subtraction was coupled with extended ratio subtraction, constant multiplication, derivative subtraction coupled constant multiplication, and spectrum subtraction can be applied for the analysis of partially overlapped spectra. On the other hand severely overlapped spectra can be analyzed by constant center and the novel methods namely differential dual wavelength (D(1) DWL) for CQ, ratio difference and differential derivative ratio (D(1) DR) for FCP, while LH was determined by applying constant value via amplitude difference followed by successive ratio subtraction, and successive derivative subtraction.
2.Therapeutic use of topical corticosteroids in the vesiculobullous lesions of incontinentia pigmenti.
Kaya TI1, Tursen U, Ikizoglu G. Clin Exp Dermatol. 2009 Dec;34(8):e611-3. doi: 10.1111/j.1365-2230.2009.03301.x. Epub 2009 Jun 1.
Incontinentia pigmenti (IP) is a rare genodermatosis caused by a mutation of nuclear factor kappa B essential modulator gene. There is no specific treatment for IP, therefore it has been claimed that there is no effective treatment to hasten resolution of any of the phases of IP. However, the initial vesiculobullous stage of IP is characterized histopathologically by eosinophilic inflammation, which is expected to respond to corticosteroids. An 18-day-old female neonate was seen, with vesicles on her trunk and limbs diagnosed as the vesiculobullous stage of IP. The patient was treated with a double-compound cream containing a potent corticosteroid (difluocortolone valerate 0.1%) and an antiseptic (chlorquinaldol 1%), to be applied to the lesions twice daily. Five days later, resolution of the lesions was almost complete. As chlorquinaldol has no known anti-inflammatory activity, we attribute this improvement to difluocortolone valerate. This case shows that early lesions of IP with eosinophilic inflammation are treatable.
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CAS 72-80-0 Chlorquinaldol

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