Chlorprothixene - CAS 113-59-7
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Not Intended for Therapeutic Use. For research use only.
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Dopamine Receptor
Chlorprothixene has strong binding affinities to dopamine and histamine receptors, such as D1, D2, D3, D5, H1, 5-HT2, 5-HT6 and 5-HT7, with Ki of 18 nM, 2.96 nM, 4.56 nM, 9 nM, 3.75 nM, 9.4 nM, 3 nM and 5.6 nM, respectively.
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1. Titrimetric Determination of Some Thioxanthene Derivatives
Mohamed lbrahim Walash, Mohamed Rizk and Amina El-Brashy*. ANALYST, AUGUST 1988, VOL. 113
The reaction product was applied to a silica-gel plate, using 3% ammonium acetate in methanol-water (100 + 20) as the developing system which showed only one spot (RF 0.73). Chlorprothixene and chlorprothixene sulphoxide (prepared by oxidation of the former with alkaline permanganate14) gave two spots with RF values of 0.66 and 0.55, respectively. Chlorprothixene could be determined in the presence of its sulphoxide using the proposed method as the sulphoxide did not interfere. Hence, it can be concluded that this method is specific for the determination of thioxanthenes in the presence of thioxanthones or their decomposition products.
2. Adsorptive Preconcentration for Voltammetric Measurements of Trace Levels of Chlorprothixene
Peng Tuzhi, Yang Zhongping and Li Huiping. ANALYST, JULY 1991, VOL. 116
Forced convection during the accumulation step affects the resulting stripping peak current by increasing the rate of transport of chlorprothixene molecules to the electrode surface. For example, a five-fold peak enhancement was observed for a stirred (400 rev min-1) solution compared with a quiescent solution (0.3 pg ml-1 of chlorprothixene, 1 min preconcentration period). Such mass-transport control indicates a fast rate of adsorption.
3. Quantitative analysis of fluphenazine hydrochloride in human urine using excitation-emission matrix fluorescence based on oxidation derivatization and combined with second-order calibration methods
Shu-Fang Li, Hai-Long Wu*. Anal. Methods, 2010, 2, 1069–1077
FPH is a weak fluorescent substance. Mellinger and Keeler suggested its oxidation to sulfoxide as the reason for enhancement of fluorescence intensity. It can be easily oxidized by potassium permanganate (KMnO4) in room temperature to a highly fluorescent derivative. The oxidation reaction scheme for FPH was described in Fig. 1(a). In the present work, we used ascorbic acid as an antioxidant to react with excess KMnO4 and collected the fluorescence spectra of the samples as quickly as possible after the preparations were finished. Chlorprothixene (CPT) is an antipsychotic drug of the thioxanthene class, which has a similar oxidation mechanism under the same conditions and herein was used as an interferent in the determination of FPH. The oxidation reaction scheme for CPT was described in Fig. 1(b). We have attempted to utilize excitation-emission matrix fluorescence (EEM) to quantitative analysis of FPH in human urine samples with the aid of second-order calibration methods in this paper.
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CAS 113-59-7 Chlorprothixene

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