Chlorpromazine HCl - CAS 69-09-0
Catalog number: 69-09-0
Category: Inhibitor
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Molecular Formula:
Molecular Weight:
Dopamine Receptor
Chlorpromazine HCl is a dopamine and potassium channel inhibitor with IC50 of 6.1 and 16 μM for inward-rectifying K+ currents and time-independent outward currents.
Canonical SMILES:
1.Chlorpromazine versus reserpine for schizophrenia.
Nur S1, Adams CE. Cochrane Database Syst Rev. 2016 Apr 28;4:CD012122. doi: 10.1002/14651858.CD012122.pub2.
BACKGROUND: In the 1940s reserpine, refined from a plant extract that had been used for centuries, began to be used as a treatment for people with mental disorders and was one of the very first antipsychotic drugs. Its irreversible pharmacological potency and adverse effects meant that it has been withdrawn in the UK and its role has been superceded by 'newer' compounds. The effects of reserpine are of historical interest although there are some reports of it still being used in highly specialist situations in psychiatry. Chlorpromazine is also an old drug but it is still used for treatment of people with schizophrenia.
2.[Photodegradation of chlorpromazine, a drug-related adverse event].
Chabi Y1, Brahim K2, Da Costa M2, Caffin AG2, Camus G2, Paillet M2, Bohand X2. Soins. 2016 Apr;61(804):34-6. doi: 10.1016/j.soin.2016.02.006.
The photodegradation of an active substance during treatment is a rare drug-related adverse event which can sometimes have serious consequences. Health professionals must be aware of the specific storage and administration instructions with regard to chlorpromazine and ensure that they are respected.
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Chemical Structure

CAS 69-09-0 Chlorpromazine HCl

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