Chlorphenoxamine - CAS 77-38-3
Catalog number: 77-38-3
Category: Inhibitor
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Molecular Formula:
Molecular Weight:
Histamine Receptor
Chlorphenoxamine is an analog of diphenhydramine. It has antimuscarinic and antihistaminic properties. It has been used as an antipruritic and antiparkinsonian agent.
Solid powder
2-(1-(p-Chlorophenyl)-1-phenylethoxy)-N,N-dimethylethylamine;2-[1-(4-Chlorophenyl)-1-phenylethoxy]-N,N-dimethylethanamine;beta-Dimethylamino-aethyl-(p-chlor-alpha-methylbenzhydryl)-aether;Ethylamine, 2-[1-(p-chlorophenyl)-1-phenylethoxy]-N,N-dimethyl-;p-Chlor-alpha-methyl-diphenhydramin;N-(2-(1-p-chlorophenyl-1-phenylethoxy)ethyl)dimethylamine;1-(4-Chlorophenyl)-1-[2-(dimethylamino)ethoxy]-1-phenylethane;Contristamine; Systral
DMSO: ≥ 48 mg/mL
-20°C Freezer
Chlorphenoxamine has been used as an antipruritic and antiparkinsonian agent.
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Boiling Point:
383.7°C at 760 mmHg
Melting Point:
152.5 °C
1.093±0.06 g/cm3 | Condition: Temp: 20 °C Press: 760 Torr
Canonical SMILES:
Current Developer:
It has been approved the listing.
1.Simultaneous determination of caffeine, 8-chlorotheophylline, and chlorphenoxamine hydrochloride in ternary mixtures by ratio-spectra zero-crossing first-derivative spectrophotometric and chemometric methods.
Kelani KM1. J AOAC Int. 2005 Jul-Aug;88(4):1126-34.
A ratio-spectra zero-crossing first-derivative spectrophotometric method and 2 chemometric methods have been used for the simultaneous determination of ternary mixtures of caffeine (A), 8-chlorotheophylline (B), and chlorphenoxamine hydrochloride (C) in bulk powder and dosage forms. In the ratio-spectra zero-crossing first-derivative spectrophotometric technique (1DD), calibration curves were linear in the range of 4-20 microg/mL for A, B, and C (r = 0.9992, 0.9994, and 0.9976, respectively). The measurements were carried out at 212, 209.2, and 231.4 nm for A, B, and C, respectively. The detection limits for A, B, and C were calculated to be 0.24, 0.34, and 0.13 microg/mL, and the percentage recoveries were 99.1 +/- 0.89, 100.1 +/- 0.95, and 100.1 +/- 1.0, respectively. Two chemometric methods, namely, the partial least-squares (PLS) model and the principal component regression (PCR) model, were also used for the simultaneous determination of the 3 drugs in the ternary mixture.
2.[Significance of chromatographic methods coupled with mass spectrometry for identification of drugs for medico-legal purposes exemplified by chlorphenoxamine].
Kłys M1, Rojek S, Masełko J. Arch Med Sadowej Kryminol. 2003 Apr-Jun;53(2):137-49.
This work presented the death of the 17-year old women M.F. The direct cause of death was violent strangulation. Toxicological investigation made possible a wider explanation of the case, since M.F. was under influence of associative action of diphenhydramine and ethanol which could not avoid having an influence on the tragic events accompanying the death. Besides a comprehensive interpretation of the toxicological results in medico--legal aspect large methodic documentation has been presented which proves the usefulness of chromatographic methods coupled with spectrometry for identification of xenobiotics found.
3.Simultaneous spectrophotometric determination of chlorphenoxamine hydrochloride and caffeine in a pharmaceutical preparation using first derivative of the ratio spectra and chemometric methods.
Dinç E1, Palabiyik IM, Ustündağ O, Yurtsever F, Onur F. J Pharm Biomed Anal. 2002 May 15;28(3-4):591-600.
Three new methods are described for the simultaneous determination of chlorphenoxamine hydrochloride (CP) and caffeine (CAF) in their combination. In the first method, ratio spectra derivative spectrophotometry, analytical signals were measured at the wavelengths corresponding to either maxima and minima for both drugs in the first derivative spectra of the ratio spectra obtained by using each other spectra as divisor in their solution in 0.1 M HCl. In the other two methods, chemometric techniques, classical least-squares (CLS) and inverse least-squares (ILS), the concentration data matrix were prepared by using the synthetic mixtures containing these drugs in 0.1 M HCl. The absorbance data matrix corresponding to the concentration data matrix was obtained by the measurements of absorbances in the range 225-285 nm in the intervals with Deltalambda = 5 nm at 13 wavelengths in their zero-order spectra, then, calibration or regression was obtained by using the absorbance data matrix and concentration data matrix for the prediction of the unknown concentrations of CP and CAF in their mixture.
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CAS 77-38-3 Chlorphenoxamine

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