Chlormezanone - CAS 80-77-3
Catalog number: 80-77-3
Category: Inhibitor
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Molecular Formula:
C11H12ClNO3S
Molecular Weight:
273.74
COA:
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Targets:
Others
Description:
Chlormezanone, a non-benzodiazepine that is used in the management of anxiety. It has been suggested for use in the treatment of muscle spasm.
Purity:
>98%
Synonyms:
ASP1517; ASP 1517; ASP-1517
MSDS:
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InChIKey:
WEQAYVWKMWHEJO-UHFFFAOYSA-N
InChI:
InChI=1S/C11H12ClNO3S/c1-13-10(14)6-7-17(15,16)11(13)8-2-4-9(12)5-3-8/h2-5,11H,6-7H2,1H3
Canonical SMILES:
CN1C(S(=O)(=O)CCC1=O)C2=CC=C(C=C2)Cl
1.Erythema multiforme secondary to dimenhydrinate in a patient with previous similar reactions to pamabrom.
Tan DS1, Sklar GE. Ann Pharmacother. 2014 Mar;48(3):425-8. doi: 10.1177/1060028013518728. Epub 2014 Jan 6.
OBJECTIVE: To report a case of erythema multiforme secondary to dimenhydrinate and pamabrom cross-sensitivity.
2.Adjuvant laser acupuncture in the treatment of whiplash injuries: a prospective, randomized placebo-controlled trial.
Aigner N1, Fialka C, Radda C, Vecsei V. Wien Klin Wochenschr. 2006 Mar;118(3-4):95-9.
Following introduction of the compulsory use of seat belts in cars, whiplash injuries of the cervical spine have become common in everyday practice. Current treatment approaches lead to resolution of the symptoms within a short time in most cases but cannot prevent a small proportion of patients developing persistent health problems. The effects of adjuvant treatment with laser acupuncture on the acute symptoms and the results one year after the injury were studied in this prospective, randomized, placebo-controlled single-blind study. One group of patients (n = 23) were treated with laser acupuncture (5 mW HeNe laser on 22 acupuncture points for 15 s each) plus cervical collar and a combination of paracetamol and chlormezanone; a second group (n = 22) received the same treatments but with the use of a placebo laser. The treatment was given three times per week until the patient was asymptomatic. No statistically significant advantage of the laser acupuncture treatment was found in the acute phase (mobility in all three planes, duration of pain and duration of use of a cervical collar) or the chronic phase (drug use and the incidences of chronic recurrent problems such as myofascial pain, headaches, vertigo and tinnitus).
3.Investigations of interactions of chlormezanone racemate and its enantiomers on human keratinocytes and human leucoytes in vitro.
Wollina U1, Hipler UC, Seeling A, Oelschlager H. Skin Pharmacol Physiol. 2005 May-Jun;18(3):132-8.
Chlormezanone is a centrally acting muscle relaxant introduced in human therapy as a racemic substance. The following investigation was performed in order to investigate whether the racemate and both enantiomers differ in their potential cytotoxicty in vitro. We investigated antiproliferative effects and cytotoxicity (PicoGreen and ATP assay) for human HaCaT keratinocytes, production of oxygen radicals (ROS) by human interleukin-3-stimulated leukocytes (Lucigenin assay) and production of sulfoleukotrienes (Cellular Antigen Stimulation Test - CAST) by human leukocytes. In the dosage range of 0.001 to 0.1 mg/ ml chlormezanone, no antiproliferative effects were measured with the racemate and both enantiomers. At 1.0 mg/ml, a decrease of proliferative activity was seen after 48 h incubation time of about 50% for the enantiomers and of about 80% for the racemate (PicoGreen) and 50% (enantiomers) or 21% (racemate) in the ATP assay, respectively.
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CAS 80-77-3 Chlormezanone

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